Genomic imprinting of Mash2, a mouse gene required for trophoblast development

The mouse gene Mash2 encodes a transcription factor required for development of trophoblast progenitors. Mash2 − homozygous mutant embryos die at 10 days post–coitum from placental failure. Here we show that Mash2 is genomically imprinted. First, Mash2+/− embryos inheriting a wild–type allele from t...

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