Mesenchymal stem cells reduce hypoxia-induced apoptosis in alveolar epithelial cells by modulating HIF and ROS hypoxic signaling

Distal lung diseases, such as pulmonary fibrosis or acute lung injury, are commonly associated with local alveolar hypoxia that may be deleterious through the stimulation of alveolar epithelial cell (AEC) apoptosis. In various murine models of alveolar injury, administration of allogenic human mesen...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2018-03, Vol.314 (3), p.L360-L371
Hauptverfasser:	Bernard, Olivier, Jeny, Florence, Uzunhan, Yurdagül, Dondi, Elisabetta, Terfous, Rahma, Label, Rabab, Sutton, Angela, Larghero, Jérôme, Vanneaux, Valérie, Nunes, Hilario, Boncoeur, Emilie, Planès, Carole, Dard, Nicolas
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Alveolar Epithelial Cells - cytology Alveolar Epithelial Cells - physiology Alveoli Animal models Animals Antioxidants Apoptosis Bcl-2 protein BNIP3 protein Cells, Cultured Conditioning Epithelial cells Fibrosis Hepatocyte growth factor Humans Hypoxia Hypoxia - physiopathology Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factors Keratinocyte growth factor Life Sciences Lung diseases Male Mesenchymal stem cells Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - physiology Mesenchyme Paracrine signalling Pulmonary Alveoli - cytology Pulmonary Alveoli - physiology Pulmonary fibrosis Rats Rats, Sprague-Dawley Reactive oxygen species Reactive Oxygen Species - metabolism Secretion Signal Transduction Stem cell transplantation Stem cells
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