Kynurenine-3-monooxygenase expression is activated in the pancreatic endocrine cells by diabetes and its blockade improves glucose-stimulated insulin secretion

Type 2 diabetes is associated with an inflammatory phenotype in the pancreatic islets. We previously demonstrated that proinflammatory cytokines potently activate the tryptophan/kynurenine pathway (TKP) in INS-1 cells and in normal rat islets. Here we examined: (1) the TKP enzymes expression in the...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2022-11, Vol.1868 (11), p.166509-166509, Article 166509
Hauptverfasser:	Liu, Junjun, Bailbé, Danielle, Raynal, Sophie, Carbonne, Christel, Zhen, Delong, Dairou, Julien, Gausseres, Blandine, Armanet, Mathieu, Domet, Thomas, Pitasi, Caterina L., Movassat, Jamileh, Lim, Chai K., Guillemin, Gilles J., Autier, Valérie, Kergoat, Micheline, Portha, Bernard
Format:	Artikel
Sprache:	eng
Schlagworte:	Life Sciences
Online-Zugang:	Volltext
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