Influence of Enantiomeric Inhibitors on the Dynamics of Acetylcholinesterase Measured by Elastic Incoherent Neutron Scattering
The scattering of neutrons can be used to provide information on the structure and dynamics of biological systems on multiple length and time scales. Pursuant to a National Science Foundation-funded workshop in February 2018, recent developments in this field are reviewed here, as well as future pro...
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| Veröffentlicht in: | The journal of physical chemistry. B 2018-09, Vol.122 (36), p.8516-8525 |
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| creator | Ashkar, Rana Bilheux, Hassina Bordallo, Heliosa Briber, Robert Callaway, David Cheng, Xiaolin Chu, Xiang-Qiang Curtis, Joseph Dadmun, Mark Fenimore, Paul Fushman, David Gabel, Frank Gupta, Kushol Herberle, Frederick Heinrich, Frank Hong, Liang Katsaras, John Kelman, Zvi Kharlampieva, Eugenia Kneller, Gerald Kovalevsky, Andrey Krueger, Susan Langan, Paul Lieberman, Raquel Liu, Yun Losche, Mathias Lyman, Edward Mao, Yimin Marino, John Mattos, Carla Meilleur, Flora Moody, Peter Nickels, Jonathan O'Dell, William O'Neill, Hugh Perez-Salas, Ursula Peters, Judith Petridis, Loukas Sokolov, Alexei Stanley, Christopher Wagner, Norman Weinrich, Michael Weiss, Kevin Wymore, Troy Zhang, Yang Smith, Jeremy |
| description | The scattering of neutrons can be used to provide information on the structure and dynamics of biological systems on multiple length and time scales. Pursuant to a National Science Foundation-funded workshop in February 2018, recent developments in this field are reviewed here, as well as future prospects that can be expected given recent advances in sources, instrumentation and computational power and methods. Crystallography, solution scattering, dynamics, membranes, labeling and imaging are examined. For the extraction of maximum information, the incorporation of judicious specific deuterium labeling, the integration of several types of experiment, and interpretation using high-performance computer simulation models are often found to be particularly powerful. |
| doi_str_mv | 10.1021/acs.jpcb.8b05485 |
| format | Article |
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| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_03930632v1 |
| source | ACS Publications |
| subjects | Biological Physics Physics |
| title | Influence of Enantiomeric Inhibitors on the Dynamics of Acetylcholinesterase Measured by Elastic Incoherent Neutron Scattering |
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