Clinical presentation and follow-up of women affected by Brugada syndrome
Studies in Brugada syndrome (BrS) have mainly consisted of men. The purpose of this study was to describe the clinical characteristics and arrhythmic risk factors in BrS women. Consecutive BrS patients were enrolled from 1993 and followed prospectively. Among 1613 patients, 494 were women (mean age...
Gespeichert in:
| Veröffentlicht in: | Heart rhythm 2019-02, Vol.16 (2), p.260-267 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 267 |
|---|---|
| container_issue | 2 |
| container_start_page | 260 |
| container_title | Heart rhythm |
| container_volume | 16 |
| creator | Berthome, Pauline Tixier, Romain Briand, Jean Geoffroy, Olivier Babuty, Dominique Mansourati, Jacques Jesel, Laurence Dupuis, Jean-Marc Bru, Paul Kyndt, Florence Guyomarch, Béatrice Thollet, Aurélie Behar, Nathalie Mabo, Philippe Sacher, Frédéric Probst, Vincent Gourraud, Jean-Baptiste |
| description | Studies in Brugada syndrome (BrS) have mainly consisted of men.
The purpose of this study was to describe the clinical characteristics and arrhythmic risk factors in BrS women.
Consecutive BrS patients were enrolled from 1993 and followed prospectively.
Among 1613 patients, 494 were women (mean age 47 ± 16 years). Women were more frequently asymptomatic than men (423 [86%] vs 867 [77%], respectively; P = .001) and less frequently had a spontaneous ECG pattern (107 [22%] vs 398 [36%], respectively; P |
| doi_str_mv | 10.1016/j.hrthm.2018.08.032 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_03896423v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1547527118309032</els_id><sourcerecordid>2101267093</sourcerecordid><originalsourceid>FETCH-LOGICAL-c554t-a874dd3c9d5723816e4b9d604ce35d4d5848f25d1b00608246f6f1ff30d7ac8b3</originalsourceid><addsrcrecordid>eNp9kE1rGzEQQEVISVK3v6BQ9pgc1tX3ag89JCZpAoZe2rPQSqNaZnflSrsJ_veR49THwsAMM29m4CH0heAlwUR-2y43adoMS4qJWuISjJ6hKyKErJlqyPmh5k0taEMu0cectxjTVmJ2gS4ZJi1Tglyhp1UfxmBNX-0SZBgnM4U4VmZ0lY99H1_qeVdFX73EAUrbe7ATuKrbV3dp_mOcqfJ-dKlMP6EP3vQZPr_nBfr9cP9r9Vivf_54Wt2uaysEn2qjGu4cs60TDWWKSOBd6yTmFphw3AnFlafCkQ5jiRXl0ktPvGfYNcaqji3QzfHuxvR6l8Jg0l5HE_Tj7VofepipVnLKnklhr4_sLsW_M-RJDyFb6HszQpyzpkUklQ1uWUHZEbUp5pzAn24TrA--9Va_-dYH3xqXYLRsfX1_MHcDuNPOP8EF-H4EoCh5DpB0tgFGCy6kolK7GP774BWzIJD4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2101267093</pqid></control><display><type>article</type><title>Clinical presentation and follow-up of women affected by Brugada syndrome</title><source>ScienceDirect Journals (5 years ago - present)</source><creator>Berthome, Pauline ; Tixier, Romain ; Briand, Jean ; Geoffroy, Olivier ; Babuty, Dominique ; Mansourati, Jacques ; Jesel, Laurence ; Dupuis, Jean-Marc ; Bru, Paul ; Kyndt, Florence ; Guyomarch, Béatrice ; Thollet, Aurélie ; Behar, Nathalie ; Mabo, Philippe ; Sacher, Frédéric ; Probst, Vincent ; Gourraud, Jean-Baptiste</creator><creatorcontrib>Berthome, Pauline ; Tixier, Romain ; Briand, Jean ; Geoffroy, Olivier ; Babuty, Dominique ; Mansourati, Jacques ; Jesel, Laurence ; Dupuis, Jean-Marc ; Bru, Paul ; Kyndt, Florence ; Guyomarch, Béatrice ; Thollet, Aurélie ; Behar, Nathalie ; Mabo, Philippe ; Sacher, Frédéric ; Probst, Vincent ; Gourraud, Jean-Baptiste</creatorcontrib><description>Studies in Brugada syndrome (BrS) have mainly consisted of men.
The purpose of this study was to describe the clinical characteristics and arrhythmic risk factors in BrS women.
Consecutive BrS patients were enrolled from 1993 and followed prospectively.
Among 1613 patients, 494 were women (mean age 47 ± 16 years). Women were more frequently asymptomatic than men (423 [86%] vs 867 [77%], respectively; P = .001) and less frequently had a spontaneous ECG pattern (107 [22%] vs 398 [36%], respectively; P <.001). During median [25th, 75th percentile] follow-up of 57 [23, 118] vs 62 [22, 113] months (P = .65), arrhythmic events occurred in 12 women (2%) vs 79 men (7%) (P = .0005). Mean age at the first event was 48.6 ± 17.8 years for women vs 43 ± 14.2 years for men (P <.001). Gender was significantly related to cardiac events (hazard ratio [HR] 2.96; 95% confidence interval [CI] 1.6–5.4; P = .0005). In multivariate analysis, event predictors in women were index patient status (HR 10.15; 95% CI 1.7–61.4; P = .01), previous sudden cardiac death (HR 69.4; 95% CI 15–312.5; P <.0001), syncope (HR 6.8; 95% CI 1.4–34.5; P = .02), fragmented QRS (HR 20.2; 95% CI 1.8–228.9; P = .02), and QRS duration >120 ms (HR 4.7; 95% CI 1.2–19.5; P = .03).
Women represent a lower-risk group than men among individuals with BrS. In asymptomatic women, fragmented QRS and QRS >120 ms seem to be the only event predictors.</description><identifier>ISSN: 1547-5271</identifier><identifier>EISSN: 1556-3871</identifier><identifier>DOI: 10.1016/j.hrthm.2018.08.032</identifier><identifier>PMID: 30193851</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Arrhythmia ; Brugada syndrome ; Cardiology and cardiovascular system ; Human health and pathology ; Life Sciences ; Prognosis ; Risk factors ; Sudden death ; Women</subject><ispartof>Heart rhythm, 2019-02, Vol.16 (2), p.260-267</ispartof><rights>2018 Heart Rhythm Society</rights><rights>Copyright © 2018 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c554t-a874dd3c9d5723816e4b9d604ce35d4d5848f25d1b00608246f6f1ff30d7ac8b3</citedby><cites>FETCH-LOGICAL-c554t-a874dd3c9d5723816e4b9d604ce35d4d5848f25d1b00608246f6f1ff30d7ac8b3</cites><orcidid>0000-0003-3051-2560 ; 0000-0002-6697-7194</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.hrthm.2018.08.032$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30193851$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03896423$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Berthome, Pauline</creatorcontrib><creatorcontrib>Tixier, Romain</creatorcontrib><creatorcontrib>Briand, Jean</creatorcontrib><creatorcontrib>Geoffroy, Olivier</creatorcontrib><creatorcontrib>Babuty, Dominique</creatorcontrib><creatorcontrib>Mansourati, Jacques</creatorcontrib><creatorcontrib>Jesel, Laurence</creatorcontrib><creatorcontrib>Dupuis, Jean-Marc</creatorcontrib><creatorcontrib>Bru, Paul</creatorcontrib><creatorcontrib>Kyndt, Florence</creatorcontrib><creatorcontrib>Guyomarch, Béatrice</creatorcontrib><creatorcontrib>Thollet, Aurélie</creatorcontrib><creatorcontrib>Behar, Nathalie</creatorcontrib><creatorcontrib>Mabo, Philippe</creatorcontrib><creatorcontrib>Sacher, Frédéric</creatorcontrib><creatorcontrib>Probst, Vincent</creatorcontrib><creatorcontrib>Gourraud, Jean-Baptiste</creatorcontrib><title>Clinical presentation and follow-up of women affected by Brugada syndrome</title><title>Heart rhythm</title><addtitle>Heart Rhythm</addtitle><description>Studies in Brugada syndrome (BrS) have mainly consisted of men.
The purpose of this study was to describe the clinical characteristics and arrhythmic risk factors in BrS women.
Consecutive BrS patients were enrolled from 1993 and followed prospectively.
Among 1613 patients, 494 were women (mean age 47 ± 16 years). Women were more frequently asymptomatic than men (423 [86%] vs 867 [77%], respectively; P = .001) and less frequently had a spontaneous ECG pattern (107 [22%] vs 398 [36%], respectively; P <.001). During median [25th, 75th percentile] follow-up of 57 [23, 118] vs 62 [22, 113] months (P = .65), arrhythmic events occurred in 12 women (2%) vs 79 men (7%) (P = .0005). Mean age at the first event was 48.6 ± 17.8 years for women vs 43 ± 14.2 years for men (P <.001). Gender was significantly related to cardiac events (hazard ratio [HR] 2.96; 95% confidence interval [CI] 1.6–5.4; P = .0005). In multivariate analysis, event predictors in women were index patient status (HR 10.15; 95% CI 1.7–61.4; P = .01), previous sudden cardiac death (HR 69.4; 95% CI 15–312.5; P <.0001), syncope (HR 6.8; 95% CI 1.4–34.5; P = .02), fragmented QRS (HR 20.2; 95% CI 1.8–228.9; P = .02), and QRS duration >120 ms (HR 4.7; 95% CI 1.2–19.5; P = .03).
Women represent a lower-risk group than men among individuals with BrS. In asymptomatic women, fragmented QRS and QRS >120 ms seem to be the only event predictors.</description><subject>Arrhythmia</subject><subject>Brugada syndrome</subject><subject>Cardiology and cardiovascular system</subject><subject>Human health and pathology</subject><subject>Life Sciences</subject><subject>Prognosis</subject><subject>Risk factors</subject><subject>Sudden death</subject><subject>Women</subject><issn>1547-5271</issn><issn>1556-3871</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kE1rGzEQQEVISVK3v6BQ9pgc1tX3ag89JCZpAoZe2rPQSqNaZnflSrsJ_veR49THwsAMM29m4CH0heAlwUR-2y43adoMS4qJWuISjJ6hKyKErJlqyPmh5k0taEMu0cectxjTVmJ2gS4ZJi1Tglyhp1UfxmBNX-0SZBgnM4U4VmZ0lY99H1_qeVdFX73EAUrbe7ATuKrbV3dp_mOcqfJ-dKlMP6EP3vQZPr_nBfr9cP9r9Vivf_54Wt2uaysEn2qjGu4cs60TDWWKSOBd6yTmFphw3AnFlafCkQ5jiRXl0ktPvGfYNcaqji3QzfHuxvR6l8Jg0l5HE_Tj7VofepipVnLKnklhr4_sLsW_M-RJDyFb6HszQpyzpkUklQ1uWUHZEbUp5pzAn24TrA--9Va_-dYH3xqXYLRsfX1_MHcDuNPOP8EF-H4EoCh5DpB0tgFGCy6kolK7GP774BWzIJD4</recordid><startdate>201902</startdate><enddate>201902</enddate><creator>Berthome, Pauline</creator><creator>Tixier, Romain</creator><creator>Briand, Jean</creator><creator>Geoffroy, Olivier</creator><creator>Babuty, Dominique</creator><creator>Mansourati, Jacques</creator><creator>Jesel, Laurence</creator><creator>Dupuis, Jean-Marc</creator><creator>Bru, Paul</creator><creator>Kyndt, Florence</creator><creator>Guyomarch, Béatrice</creator><creator>Thollet, Aurélie</creator><creator>Behar, Nathalie</creator><creator>Mabo, Philippe</creator><creator>Sacher, Frédéric</creator><creator>Probst, Vincent</creator><creator>Gourraud, Jean-Baptiste</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0003-3051-2560</orcidid><orcidid>https://orcid.org/0000-0002-6697-7194</orcidid></search><sort><creationdate>201902</creationdate><title>Clinical presentation and follow-up of women affected by Brugada syndrome</title><author>Berthome, Pauline ; Tixier, Romain ; Briand, Jean ; Geoffroy, Olivier ; Babuty, Dominique ; Mansourati, Jacques ; Jesel, Laurence ; Dupuis, Jean-Marc ; Bru, Paul ; Kyndt, Florence ; Guyomarch, Béatrice ; Thollet, Aurélie ; Behar, Nathalie ; Mabo, Philippe ; Sacher, Frédéric ; Probst, Vincent ; Gourraud, Jean-Baptiste</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c554t-a874dd3c9d5723816e4b9d604ce35d4d5848f25d1b00608246f6f1ff30d7ac8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Arrhythmia</topic><topic>Brugada syndrome</topic><topic>Cardiology and cardiovascular system</topic><topic>Human health and pathology</topic><topic>Life Sciences</topic><topic>Prognosis</topic><topic>Risk factors</topic><topic>Sudden death</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berthome, Pauline</creatorcontrib><creatorcontrib>Tixier, Romain</creatorcontrib><creatorcontrib>Briand, Jean</creatorcontrib><creatorcontrib>Geoffroy, Olivier</creatorcontrib><creatorcontrib>Babuty, Dominique</creatorcontrib><creatorcontrib>Mansourati, Jacques</creatorcontrib><creatorcontrib>Jesel, Laurence</creatorcontrib><creatorcontrib>Dupuis, Jean-Marc</creatorcontrib><creatorcontrib>Bru, Paul</creatorcontrib><creatorcontrib>Kyndt, Florence</creatorcontrib><creatorcontrib>Guyomarch, Béatrice</creatorcontrib><creatorcontrib>Thollet, Aurélie</creatorcontrib><creatorcontrib>Behar, Nathalie</creatorcontrib><creatorcontrib>Mabo, Philippe</creatorcontrib><creatorcontrib>Sacher, Frédéric</creatorcontrib><creatorcontrib>Probst, Vincent</creatorcontrib><creatorcontrib>Gourraud, Jean-Baptiste</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Heart rhythm</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berthome, Pauline</au><au>Tixier, Romain</au><au>Briand, Jean</au><au>Geoffroy, Olivier</au><au>Babuty, Dominique</au><au>Mansourati, Jacques</au><au>Jesel, Laurence</au><au>Dupuis, Jean-Marc</au><au>Bru, Paul</au><au>Kyndt, Florence</au><au>Guyomarch, Béatrice</au><au>Thollet, Aurélie</au><au>Behar, Nathalie</au><au>Mabo, Philippe</au><au>Sacher, Frédéric</au><au>Probst, Vincent</au><au>Gourraud, Jean-Baptiste</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical presentation and follow-up of women affected by Brugada syndrome</atitle><jtitle>Heart rhythm</jtitle><addtitle>Heart Rhythm</addtitle><date>2019-02</date><risdate>2019</risdate><volume>16</volume><issue>2</issue><spage>260</spage><epage>267</epage><pages>260-267</pages><issn>1547-5271</issn><eissn>1556-3871</eissn><abstract>Studies in Brugada syndrome (BrS) have mainly consisted of men.
The purpose of this study was to describe the clinical characteristics and arrhythmic risk factors in BrS women.
Consecutive BrS patients were enrolled from 1993 and followed prospectively.
Among 1613 patients, 494 were women (mean age 47 ± 16 years). Women were more frequently asymptomatic than men (423 [86%] vs 867 [77%], respectively; P = .001) and less frequently had a spontaneous ECG pattern (107 [22%] vs 398 [36%], respectively; P <.001). During median [25th, 75th percentile] follow-up of 57 [23, 118] vs 62 [22, 113] months (P = .65), arrhythmic events occurred in 12 women (2%) vs 79 men (7%) (P = .0005). Mean age at the first event was 48.6 ± 17.8 years for women vs 43 ± 14.2 years for men (P <.001). Gender was significantly related to cardiac events (hazard ratio [HR] 2.96; 95% confidence interval [CI] 1.6–5.4; P = .0005). In multivariate analysis, event predictors in women were index patient status (HR 10.15; 95% CI 1.7–61.4; P = .01), previous sudden cardiac death (HR 69.4; 95% CI 15–312.5; P <.0001), syncope (HR 6.8; 95% CI 1.4–34.5; P = .02), fragmented QRS (HR 20.2; 95% CI 1.8–228.9; P = .02), and QRS duration >120 ms (HR 4.7; 95% CI 1.2–19.5; P = .03).
Women represent a lower-risk group than men among individuals with BrS. In asymptomatic women, fragmented QRS and QRS >120 ms seem to be the only event predictors.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30193851</pmid><doi>10.1016/j.hrthm.2018.08.032</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-3051-2560</orcidid><orcidid>https://orcid.org/0000-0002-6697-7194</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1547-5271 |
| ispartof | Heart rhythm, 2019-02, Vol.16 (2), p.260-267 |
| issn | 1547-5271 1556-3871 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_03896423v1 |
| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Arrhythmia Brugada syndrome Cardiology and cardiovascular system Human health and pathology Life Sciences Prognosis Risk factors Sudden death Women |
| title | Clinical presentation and follow-up of women affected by Brugada syndrome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T21%3A54%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinical%20presentation%20and%20follow-up%20of%20women%20affected%20by%20Brugada%20syndrome&rft.jtitle=Heart%20rhythm&rft.au=Berthome,%20Pauline&rft.date=2019-02&rft.volume=16&rft.issue=2&rft.spage=260&rft.epage=267&rft.pages=260-267&rft.issn=1547-5271&rft.eissn=1556-3871&rft_id=info:doi/10.1016/j.hrthm.2018.08.032&rft_dat=%3Cproquest_hal_p%3E2101267093%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2101267093&rft_id=info:pmid/30193851&rft_els_id=S1547527118309032&rfr_iscdi=true |