First evidence of the activation of Cg-timp, an immune response component of pacific oysters, through a damage-associated molecular pattern pathway
In a previous work, we characterized a Crassostrea gigas cDNA ( Cg-timp) encoding a protein which presents all the features of vertebrate tissue inhibitor of metalloproteinase (TIMP). The expression pattern of this gene led us to propose that Cg-timp is an important factor in oyster wound healing an...
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| Veröffentlicht in: | Developmental & Comparative Immunology 2007, Vol.31 (1), p.1-11 |
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| creator | Montagnani, C. Avarre, J.C. de Lorgeril, J. Quiquand, M. Boulo, V. Escoubas, J.M. |
| description | In a previous work, we characterized a
Crassostrea gigas cDNA (
Cg-timp) encoding a protein which presents all the features of vertebrate tissue inhibitor of metalloproteinase (TIMP). The expression pattern of this gene led us to propose that
Cg-timp is an important factor in oyster wound healing and defense mechanisms. Here we describe the analysis of
Cg-timp expression in oysters challenged by live or dead bacteria as well as by bacterial secretory/excretory products and metalloproteinase. Surprisingly, bacterial secretory/excretory products activate
Cg-timp gene expression whereas heat-inactivated ones do not. To address the question of the signal transduction pathway involved in
Cg-timp gene activation, we isolated and sequenced
Cg-timp promoter and upstream region. A 1-kb genomic DNA fragment flanking the 5′-end of the gene contains several regulatory elements and notably three NF-
κB binding sites. The potential involvement of these motifs in
Cg-timp gene regulation is discussed. |
| doi_str_mv | 10.1016/j.dci.2006.04.002 |
| format | Article |
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Crassostrea gigas cDNA (
Cg-timp) encoding a protein which presents all the features of vertebrate tissue inhibitor of metalloproteinase (TIMP). The expression pattern of this gene led us to propose that
Cg-timp is an important factor in oyster wound healing and defense mechanisms. Here we describe the analysis of
Cg-timp expression in oysters challenged by live or dead bacteria as well as by bacterial secretory/excretory products and metalloproteinase. Surprisingly, bacterial secretory/excretory products activate
Cg-timp gene expression whereas heat-inactivated ones do not. To address the question of the signal transduction pathway involved in
Cg-timp gene activation, we isolated and sequenced
Cg-timp promoter and upstream region. A 1-kb genomic DNA fragment flanking the 5′-end of the gene contains several regulatory elements and notably three NF-
κB binding sites. The potential involvement of these motifs in
Cg-timp gene regulation is discussed.</description><identifier>ISSN: 0145-305X</identifier><identifier>EISSN: 1879-0089</identifier><identifier>EISSN: 1365-2567</identifier><identifier>DOI: 10.1016/j.dci.2006.04.002</identifier><identifier>PMID: 16793134</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Animals ; Bacillus ; Base Sequence ; Biodiversity ; Crassostrea - genetics ; Crassostrea - immunology ; Crassostrea gigas ; Damage-associated molecular pattern ; Gene Expression Regulation - genetics ; Gene Expression Regulation - immunology ; Life Sciences ; Marine ; Metalloproteinase ; Molecular Sequence Data ; Mollusk immunity ; Oyster ; Populations and Evolution ; Signal Transduction ; Tissue inhibitor of metalloproteinase ; Tissue Inhibitor of Metalloproteinases - genetics ; Tissue Inhibitor of Metalloproteinases - immunology ; Tissue Inhibitor of Metalloproteinases - metabolism ; Transcriptional Activation ; Vibrio - immunology ; Wound Healing - genetics ; Wound Healing - immunology</subject><ispartof>Developmental & Comparative Immunology, 2007, Vol.31 (1), p.1-11</ispartof><rights>2006 Elsevier Ltd</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-3d80686f691812d4b2d7a4a5e8b5057b05b367b0bb2975226ce2ea91b5c158473</citedby><cites>FETCH-LOGICAL-c525t-3d80686f691812d4b2d7a4a5e8b5057b05b367b0bb2975226ce2ea91b5c158473</cites><orcidid>0000-0002-6138-1148 ; 0000-0002-0861-7967</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.dci.2006.04.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16793134$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03895692$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Montagnani, C.</creatorcontrib><creatorcontrib>Avarre, J.C.</creatorcontrib><creatorcontrib>de Lorgeril, J.</creatorcontrib><creatorcontrib>Quiquand, M.</creatorcontrib><creatorcontrib>Boulo, V.</creatorcontrib><creatorcontrib>Escoubas, J.M.</creatorcontrib><title>First evidence of the activation of Cg-timp, an immune response component of pacific oysters, through a damage-associated molecular pattern pathway</title><title>Developmental & Comparative Immunology</title><addtitle>Dev Comp Immunol</addtitle><description>In a previous work, we characterized a
Crassostrea gigas cDNA (
Cg-timp) encoding a protein which presents all the features of vertebrate tissue inhibitor of metalloproteinase (TIMP). The expression pattern of this gene led us to propose that
Cg-timp is an important factor in oyster wound healing and defense mechanisms. Here we describe the analysis of
Cg-timp expression in oysters challenged by live or dead bacteria as well as by bacterial secretory/excretory products and metalloproteinase. Surprisingly, bacterial secretory/excretory products activate
Cg-timp gene expression whereas heat-inactivated ones do not. To address the question of the signal transduction pathway involved in
Cg-timp gene activation, we isolated and sequenced
Cg-timp promoter and upstream region. A 1-kb genomic DNA fragment flanking the 5′-end of the gene contains several regulatory elements and notably three NF-
κB binding sites. The potential involvement of these motifs in
Cg-timp gene regulation is discussed.</description><subject>Animals</subject><subject>Bacillus</subject><subject>Base Sequence</subject><subject>Biodiversity</subject><subject>Crassostrea - genetics</subject><subject>Crassostrea - immunology</subject><subject>Crassostrea gigas</subject><subject>Damage-associated molecular pattern</subject><subject>Gene Expression Regulation - genetics</subject><subject>Gene Expression Regulation - immunology</subject><subject>Life Sciences</subject><subject>Marine</subject><subject>Metalloproteinase</subject><subject>Molecular Sequence Data</subject><subject>Mollusk immunity</subject><subject>Oyster</subject><subject>Populations and Evolution</subject><subject>Signal Transduction</subject><subject>Tissue inhibitor of metalloproteinase</subject><subject>Tissue Inhibitor of Metalloproteinases - genetics</subject><subject>Tissue Inhibitor of Metalloproteinases - immunology</subject><subject>Tissue Inhibitor of Metalloproteinases - metabolism</subject><subject>Transcriptional Activation</subject><subject>Vibrio - immunology</subject><subject>Wound Healing - genetics</subject><subject>Wound Healing - immunology</subject><issn>0145-305X</issn><issn>1879-0089</issn><issn>1365-2567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU-r1DAUxYsovvHpB3AjWQnCa82fJk1x9Rh8PmHAjYK7kCa3MxnapibpyHwOv7ApM-hOsznh8juHyz1F8ZrgimAi3h8ra1xFMRYVriuM6ZNiQ2TTlhjL9mmxwaTmJcP8-03xIsYjzk8S_Ly4IaJpGWH1pvj14EJMCE7OwmQA-R6lAyBtkjvp5Py0Trb7MrlxvkN6Qm4clwlQgDj7KQIyfswfmNIKztq43hnkzzFBiHc5K_hlf0AaWT3qPZQ6Rm-cTmDR6Acwy6BDtqWMT6sefurzy-JZr4cIr656W3x7-Ph1-1juvnz6vL3flYZTnkpmJRZS9KIlklBbd9Q2utYcZMcxbzrMOyaydB1tG06pMEBBt6TjhnBZN-y2eHfJPehBzcGNOpyV10493u_UOsNMtly09EQy-_bCzsH_WCAmNbpoYBj0BH6JSkjGGctX_R9IccNqSXkGyQU0wccYoP-zAsFqrVcdVa5XrfUqXKtcb_a8uYYv3Qj2r-PaZwY-XADIdzs5CCoatxZrXQCTlPXuH_G_Ad4otjs</recordid><startdate>2007</startdate><enddate>2007</enddate><creator>Montagnani, C.</creator><creator>Avarre, J.C.</creator><creator>de Lorgeril, J.</creator><creator>Quiquand, M.</creator><creator>Boulo, V.</creator><creator>Escoubas, J.M.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>FR3</scope><scope>H94</scope><scope>H95</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope><scope>P64</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-6138-1148</orcidid><orcidid>https://orcid.org/0000-0002-0861-7967</orcidid></search><sort><creationdate>2007</creationdate><title>First evidence of the activation of Cg-timp, an immune response component of pacific oysters, through a damage-associated molecular pattern pathway</title><author>Montagnani, C. ; Avarre, J.C. ; de Lorgeril, J. ; Quiquand, M. ; Boulo, V. ; Escoubas, J.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c525t-3d80686f691812d4b2d7a4a5e8b5057b05b367b0bb2975226ce2ea91b5c158473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Bacillus</topic><topic>Base Sequence</topic><topic>Biodiversity</topic><topic>Crassostrea - genetics</topic><topic>Crassostrea - immunology</topic><topic>Crassostrea gigas</topic><topic>Damage-associated molecular pattern</topic><topic>Gene Expression Regulation - genetics</topic><topic>Gene Expression Regulation - immunology</topic><topic>Life Sciences</topic><topic>Marine</topic><topic>Metalloproteinase</topic><topic>Molecular Sequence Data</topic><topic>Mollusk immunity</topic><topic>Oyster</topic><topic>Populations and Evolution</topic><topic>Signal Transduction</topic><topic>Tissue inhibitor of metalloproteinase</topic><topic>Tissue Inhibitor of Metalloproteinases - genetics</topic><topic>Tissue Inhibitor of Metalloproteinases - immunology</topic><topic>Tissue Inhibitor of Metalloproteinases - metabolism</topic><topic>Transcriptional Activation</topic><topic>Vibrio - immunology</topic><topic>Wound Healing - genetics</topic><topic>Wound Healing - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Montagnani, C.</creatorcontrib><creatorcontrib>Avarre, J.C.</creatorcontrib><creatorcontrib>de Lorgeril, J.</creatorcontrib><creatorcontrib>Quiquand, M.</creatorcontrib><creatorcontrib>Boulo, V.</creatorcontrib><creatorcontrib>Escoubas, J.M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Developmental & Comparative Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Montagnani, C.</au><au>Avarre, J.C.</au><au>de Lorgeril, J.</au><au>Quiquand, M.</au><au>Boulo, V.</au><au>Escoubas, J.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>First evidence of the activation of Cg-timp, an immune response component of pacific oysters, through a damage-associated molecular pattern pathway</atitle><jtitle>Developmental & Comparative Immunology</jtitle><addtitle>Dev Comp Immunol</addtitle><date>2007</date><risdate>2007</risdate><volume>31</volume><issue>1</issue><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>0145-305X</issn><eissn>1879-0089</eissn><eissn>1365-2567</eissn><abstract>In a previous work, we characterized a
Crassostrea gigas cDNA (
Cg-timp) encoding a protein which presents all the features of vertebrate tissue inhibitor of metalloproteinase (TIMP). The expression pattern of this gene led us to propose that
Cg-timp is an important factor in oyster wound healing and defense mechanisms. Here we describe the analysis of
Cg-timp expression in oysters challenged by live or dead bacteria as well as by bacterial secretory/excretory products and metalloproteinase. Surprisingly, bacterial secretory/excretory products activate
Cg-timp gene expression whereas heat-inactivated ones do not. To address the question of the signal transduction pathway involved in
Cg-timp gene activation, we isolated and sequenced
Cg-timp promoter and upstream region. A 1-kb genomic DNA fragment flanking the 5′-end of the gene contains several regulatory elements and notably three NF-
κB binding sites. The potential involvement of these motifs in
Cg-timp gene regulation is discussed.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>16793134</pmid><doi>10.1016/j.dci.2006.04.002</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-6138-1148</orcidid><orcidid>https://orcid.org/0000-0002-0861-7967</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Free Content; Access via Wiley Online Library; IngentaConnect Free/Open Access Journals; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Bacillus Base Sequence Biodiversity Crassostrea - genetics Crassostrea - immunology Crassostrea gigas Damage-associated molecular pattern Gene Expression Regulation - genetics Gene Expression Regulation - immunology Life Sciences Marine Metalloproteinase Molecular Sequence Data Mollusk immunity Oyster Populations and Evolution Signal Transduction Tissue inhibitor of metalloproteinase Tissue Inhibitor of Metalloproteinases - genetics Tissue Inhibitor of Metalloproteinases - immunology Tissue Inhibitor of Metalloproteinases - metabolism Transcriptional Activation Vibrio - immunology Wound Healing - genetics Wound Healing - immunology |
| title | First evidence of the activation of Cg-timp, an immune response component of pacific oysters, through a damage-associated molecular pattern pathway |
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