Transgenic Mice Expressing Human Proteinase 3 Exhibit Sustained Neutrophil-Associated Peritonitis

Proteinase 3 (PR3) is a myeloid serine protease expressed in neutrophils, monocytes, and macrophages. PR3 has a number of well-characterized proinflammatory functions, including cleaving and activating chemokines and controlling cell survival and proliferation. When presented on the surface of apopt...

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Veröffentlicht in:	The Journal of immunology (1950) 2017-12, Vol.199 (11), p.3914-3924
Hauptverfasser:	Martin, Katherine R, Pederzoli-Ribeil, Magali, Pacreau, Emeline, Burgener, Sabrina S, Dahdah, Albert, Candalh, Céline, Lauret, Evelyne, Foretz, Marc, Mouthon, Luc, Lucas, Bruno, Thieblemont, Nathalie, Benarafa, Charaf, Launay, Pierre, Witko-Sarsat, Véronique
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Animals Annexin A1 - metabolism Apoptosis Cecum Cell survival Chemokines Disease Models, Animal Extravasation Humans Immunology Inflammation Leukocytes (neutrophilic) Life Sciences Lymphocytes Lymphocytes B Lymphocytes T Macrophages Mice Mice, Inbred C57BL Mice, Transgenic Monocytes Myeloblastin - genetics Myeloblastin - metabolism Neutrophils Neutrophils - immunology Peritoneal Cavity - pathology Peritoneum Peritonitis Peritonitis - chemically induced Peritonitis - immunology Phagocytosis Proteinase Proteinase 3 Rodents Sepsis Sepsis - chemically induced Sepsis - immunology Serine Serine proteinase Transgenic mice Zymosan
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