Mfsd2b and Spns2 are essential for maintenance of blood vessels during development and in anaphylactic shock

Sphingosine-1-phosphate (S1P) is a potent lipid mediator that is secreted by several cell types. We recently showed that Mfsd2b is an S1P transporter from hematopoietic cells that contributes approximately 50% plasma S1P. Here we report the characterization of compound deletion of Mfsd2b and Spns2,...

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Veröffentlicht in:	Cell reports (Cambridge) 2022-08, Vol.40 (7), p.111208-111208, Article 111208
Hauptverfasser:	Le, Thanh Nha Uyen, Nguyen, Toan Q., Kalailingam, Pazhanichamy, Nguyen, Yen Thi Kim, Sukumar, Viresh Krishnan, Tan, Clarissa Kai Hui, Tukijan, Farhana, Couty, Ludovic, Hasan, Zafrul, Del Gaudio, Ilaria, Wenk, Markus R., Cazenave-Gassiot, Amaury, Camerer, Eric, Nguyen, Long N.
Format:	Artikel
Sprache:	eng
Schlagworte:	anaphylaxis Cardiology and cardiovascular system Cellular Biology embryonic lethality hemorrhage Human health and pathology Life Sciences Mfsd2b plasma S1P S1P signaling S1P transporters sphingolipids sphingosine kinases sphingosine-1-phosphate Spns2 vascular homeostasis
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