Functional outcome after convulsive status epilepticus
OBJECTIVES:Few outcome data are available about convulsive status epilepticus managed in the intensive care unit. We studied 90-day functional outcomes and their determinants in patients with convulsive status epilepticus. DESIGN:Two hundred forty-eight convulsive status epilepticus patients admitte...
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| creator | Legriel, Stéphane Azoulay, Elie Resche-Rigon, Matthieu Lemiale, Virginie Mourvillier, Bruno Kouatchet, Achille Troché, Gilles Wolf, Manuel Galliot, Richard Dessertaine, Géraldine Combaux, Danièle Jacobs, Frederic Beuret, Pascal Megarbane, Bruno Carli, Pierre Lambert, Yves Bruneel, Fabrice Bedos, Jean-Pierre |
| description | OBJECTIVES:Few outcome data are available about convulsive status epilepticus managed in the intensive care unit. We studied 90-day functional outcomes and their determinants in patients with convulsive status epilepticus.
DESIGN:Two hundred forty-eight convulsive status epilepticus patients admitted to 18 intensive care units in 2005–2007 were included in a prospective observational cohort study. The main outcome measure was a Glasgow Outcome Scale score of 5 (good recovery) on day 90.
MAIN RESULTS:Convulsive status epilepticus occurred out of hospital in 177 (67%) patients, and all but 15 patients were still seizing at medical team arrival. The median time from convulsive status epilepticus onset to anticonvulsant drug initiation was 40 mins (interquartile range, 5–80). Total seizure duration was 85 mins (interquartile range, 46.5–180). Convulsive status epilepticus was refractory in 49 (20%) patients. The most common causes of convulsive status epilepticus were anticonvulsive agent withdrawal (36.4%) in patients with previous epilepsy and stroke (27.7%) in inaugural convulsive status epilepticus. Mechanical ventilation was needed in 210 (85%) patients. On day 90, 42 (18.8%) patients were dead, 87 (38.8%) had marked functional impairments (Glasgow Outcome Scale score, 2–4), and 95 (42.4%) had a good recovery (Glasgow Outcome Scale score, 5). Factors showing independent positive associations with poor outcome (Glasgow Outcome Scale score, |
| doi_str_mv | 10.1097/CCM.0b013e3181f859a6 |
| format | Article |
| fullrecord | <record><control><sourceid>hal_cross</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_03878493v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>oai_HAL_hal_03878493v1</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4536-ec8d4bfa45eb945119e6b89c655fc92bc0d1f2609875f49c11aca00efccf1c943</originalsourceid><addsrcrecordid>eNp9kEFLwzAUgIMobk7_gUgvHjx0vjRJmxxHcU6YeNFzSN8SVs3W0rQT_70dnRM8eAo8vu_x8hFyTWFKQWX3ef48hQIos4xK6qRQJj0hYyoYxJAodkrGAApixhUbkYsQ3gEoFxk7J6MEpIIE6Jik826LbVltjY-qrsVqYyPjWttEWG13nQ_lzkahNW0XIluX3tZtiV24JGfO-GCvDu-EvM0fXvNFvHx5fMpnyxi5YGlsUa544QwXtlBcUKpsWkiFqRAOVVIgrKhLUlAyE44rpNSgAbAO0VFUnE3I3bB3bbyum3Jjmi9dmVIvZku9nwGTmex_uKM9ywcWmyqExrqjQEHvk-k-mf6brNduBq3uio1dHaWfRj1wewBMQONdY7ZYhl-O8UwwpnpODtxn5fuA4cN3n7bRa2t8u_7_hm-T5ocK</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Functional outcome after convulsive status epilepticus</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Legriel, Stéphane ; Azoulay, Elie ; Resche-Rigon, Matthieu ; Lemiale, Virginie ; Mourvillier, Bruno ; Kouatchet, Achille ; Troché, Gilles ; Wolf, Manuel ; Galliot, Richard ; Dessertaine, Géraldine ; Combaux, Danièle ; Jacobs, Frederic ; Beuret, Pascal ; Megarbane, Bruno ; Carli, Pierre ; Lambert, Yves ; Bruneel, Fabrice ; Bedos, Jean-Pierre</creator><creatorcontrib>Legriel, Stéphane ; Azoulay, Elie ; Resche-Rigon, Matthieu ; Lemiale, Virginie ; Mourvillier, Bruno ; Kouatchet, Achille ; Troché, Gilles ; Wolf, Manuel ; Galliot, Richard ; Dessertaine, Géraldine ; Combaux, Danièle ; Jacobs, Frederic ; Beuret, Pascal ; Megarbane, Bruno ; Carli, Pierre ; Lambert, Yves ; Bruneel, Fabrice ; Bedos, Jean-Pierre</creatorcontrib><description>OBJECTIVES:Few outcome data are available about convulsive status epilepticus managed in the intensive care unit. We studied 90-day functional outcomes and their determinants in patients with convulsive status epilepticus.
DESIGN:Two hundred forty-eight convulsive status epilepticus patients admitted to 18 intensive care units in 2005–2007 were included in a prospective observational cohort study. The main outcome measure was a Glasgow Outcome Scale score of 5 (good recovery) on day 90.
MAIN RESULTS:Convulsive status epilepticus occurred out of hospital in 177 (67%) patients, and all but 15 patients were still seizing at medical team arrival. The median time from convulsive status epilepticus onset to anticonvulsant drug initiation was 40 mins (interquartile range, 5–80). Total seizure duration was 85 mins (interquartile range, 46.5–180). Convulsive status epilepticus was refractory in 49 (20%) patients. The most common causes of convulsive status epilepticus were anticonvulsive agent withdrawal (36.4%) in patients with previous epilepsy and stroke (27.7%) in inaugural convulsive status epilepticus. Mechanical ventilation was needed in 210 (85%) patients. On day 90, 42 (18.8%) patients were dead, 87 (38.8%) had marked functional impairments (Glasgow Outcome Scale score, 2–4), and 95 (42.4%) had a good recovery (Glasgow Outcome Scale score, 5). Factors showing independent positive associations with poor outcome (Glasgow Outcome Scale score, <5) were older age (odds ratio, 1.04/year; 95% confidence interval, 1.02–1.05; p = .0005), cerebral insult (odds ratio, 2.70; 95% confidence interval, 1.37–5.26; p = .007), longer seizure duration (odds ratio, 1.72/120 min; 95% confidence interval, 1.05–2.86; p = .03), on-scene focal neurologic signs (odds ratio, 2.08; 95% confidence interval, 1.03–4.16; p = .04), and refractory convulsive status epilepticus (odds ratio, 2.70; 95% confidence interval, 1.02–7.14; p = .045).
CONCLUSIONS:Ninety days after intensive care unit admission for convulsive status epilepticus, half the survivors had severe functional impairments. Longer seizure duration, cerebral insult, and refractory convulsive status epilepticus were strongly associated with poor outcomes, suggesting a role for early neuroprotective strategies.</description><identifier>ISSN: 0090-3493</identifier><identifier>EISSN: 1530-0293</identifier><identifier>DOI: 10.1097/CCM.0b013e3181f859a6</identifier><identifier>PMID: 20890201</identifier><identifier>CODEN: CCMDC7</identifier><language>eng</language><publisher>Hagerstown, MD: by the Society of Critical Care Medicine and Lippincott Williams & Wilkins</publisher><subject>Adult ; Age Factors ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Anticonvulsants - therapeutic use ; Biological and medical sciences ; Cardiology and cardiovascular system ; Cohort Studies ; Confidence Intervals ; Critical Care - methods ; Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care ; Emerging diseases ; Female ; Follow-Up Studies ; Glasgow Coma Scale ; Human health and pathology ; Humans ; Infectious diseases ; Intensive care medicine ; Intensive Care Units ; Life Sciences ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Middle Aged ; Neuropsychological Tests ; Odds Ratio ; Prospective Studies ; Pulmonology and respiratory tract ; Recovery of Function ; Respiration, Artificial - methods ; Risk Assessment ; Severity of Illness Index ; Sex Factors ; Status Epilepticus - diagnosis ; Status Epilepticus - mortality ; Status Epilepticus - therapy ; Survival Analysis ; Tomography, X-Ray Computed ; Toxicology ; Treatment Outcome</subject><ispartof>Critical care medicine, 2010-12, Vol.38 (12), p.2295-2303</ispartof><rights>2010 by the Society of Critical Care Medicine and Lippincott Williams & Wilkins</rights><rights>2015 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4536-ec8d4bfa45eb945119e6b89c655fc92bc0d1f2609875f49c11aca00efccf1c943</citedby><cites>FETCH-LOGICAL-c4536-ec8d4bfa45eb945119e6b89c655fc92bc0d1f2609875f49c11aca00efccf1c943</cites><orcidid>0000-0002-2522-2764 ; 0000-0002-8162-1508</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23475339$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20890201$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03878493$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Legriel, Stéphane</creatorcontrib><creatorcontrib>Azoulay, Elie</creatorcontrib><creatorcontrib>Resche-Rigon, Matthieu</creatorcontrib><creatorcontrib>Lemiale, Virginie</creatorcontrib><creatorcontrib>Mourvillier, Bruno</creatorcontrib><creatorcontrib>Kouatchet, Achille</creatorcontrib><creatorcontrib>Troché, Gilles</creatorcontrib><creatorcontrib>Wolf, Manuel</creatorcontrib><creatorcontrib>Galliot, Richard</creatorcontrib><creatorcontrib>Dessertaine, Géraldine</creatorcontrib><creatorcontrib>Combaux, Danièle</creatorcontrib><creatorcontrib>Jacobs, Frederic</creatorcontrib><creatorcontrib>Beuret, Pascal</creatorcontrib><creatorcontrib>Megarbane, Bruno</creatorcontrib><creatorcontrib>Carli, Pierre</creatorcontrib><creatorcontrib>Lambert, Yves</creatorcontrib><creatorcontrib>Bruneel, Fabrice</creatorcontrib><creatorcontrib>Bedos, Jean-Pierre</creatorcontrib><title>Functional outcome after convulsive status epilepticus</title><title>Critical care medicine</title><addtitle>Crit Care Med</addtitle><description>OBJECTIVES:Few outcome data are available about convulsive status epilepticus managed in the intensive care unit. We studied 90-day functional outcomes and their determinants in patients with convulsive status epilepticus.
DESIGN:Two hundred forty-eight convulsive status epilepticus patients admitted to 18 intensive care units in 2005–2007 were included in a prospective observational cohort study. The main outcome measure was a Glasgow Outcome Scale score of 5 (good recovery) on day 90.
MAIN RESULTS:Convulsive status epilepticus occurred out of hospital in 177 (67%) patients, and all but 15 patients were still seizing at medical team arrival. The median time from convulsive status epilepticus onset to anticonvulsant drug initiation was 40 mins (interquartile range, 5–80). Total seizure duration was 85 mins (interquartile range, 46.5–180). Convulsive status epilepticus was refractory in 49 (20%) patients. The most common causes of convulsive status epilepticus were anticonvulsive agent withdrawal (36.4%) in patients with previous epilepsy and stroke (27.7%) in inaugural convulsive status epilepticus. Mechanical ventilation was needed in 210 (85%) patients. On day 90, 42 (18.8%) patients were dead, 87 (38.8%) had marked functional impairments (Glasgow Outcome Scale score, 2–4), and 95 (42.4%) had a good recovery (Glasgow Outcome Scale score, 5). Factors showing independent positive associations with poor outcome (Glasgow Outcome Scale score, <5) were older age (odds ratio, 1.04/year; 95% confidence interval, 1.02–1.05; p = .0005), cerebral insult (odds ratio, 2.70; 95% confidence interval, 1.37–5.26; p = .007), longer seizure duration (odds ratio, 1.72/120 min; 95% confidence interval, 1.05–2.86; p = .03), on-scene focal neurologic signs (odds ratio, 2.08; 95% confidence interval, 1.03–4.16; p = .04), and refractory convulsive status epilepticus (odds ratio, 2.70; 95% confidence interval, 1.02–7.14; p = .045).
CONCLUSIONS:Ninety days after intensive care unit admission for convulsive status epilepticus, half the survivors had severe functional impairments. Longer seizure duration, cerebral insult, and refractory convulsive status epilepticus were strongly associated with poor outcomes, suggesting a role for early neuroprotective strategies.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Cardiology and cardiovascular system</subject><subject>Cohort Studies</subject><subject>Confidence Intervals</subject><subject>Critical Care - methods</subject><subject>Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care</subject><subject>Emerging diseases</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glasgow Coma Scale</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Intensive care medicine</subject><subject>Intensive Care Units</subject><subject>Life Sciences</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests</subject><subject>Odds Ratio</subject><subject>Prospective Studies</subject><subject>Pulmonology and respiratory tract</subject><subject>Recovery of Function</subject><subject>Respiration, Artificial - methods</subject><subject>Risk Assessment</subject><subject>Severity of Illness Index</subject><subject>Sex Factors</subject><subject>Status Epilepticus - diagnosis</subject><subject>Status Epilepticus - mortality</subject><subject>Status Epilepticus - therapy</subject><subject>Survival Analysis</subject><subject>Tomography, X-Ray Computed</subject><subject>Toxicology</subject><subject>Treatment Outcome</subject><issn>0090-3493</issn><issn>1530-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFLwzAUgIMobk7_gUgvHjx0vjRJmxxHcU6YeNFzSN8SVs3W0rQT_70dnRM8eAo8vu_x8hFyTWFKQWX3ef48hQIos4xK6qRQJj0hYyoYxJAodkrGAApixhUbkYsQ3gEoFxk7J6MEpIIE6Jik826LbVltjY-qrsVqYyPjWttEWG13nQ_lzkahNW0XIluX3tZtiV24JGfO-GCvDu-EvM0fXvNFvHx5fMpnyxi5YGlsUa544QwXtlBcUKpsWkiFqRAOVVIgrKhLUlAyE44rpNSgAbAO0VFUnE3I3bB3bbyum3Jjmi9dmVIvZku9nwGTmex_uKM9ywcWmyqExrqjQEHvk-k-mf6brNduBq3uio1dHaWfRj1wewBMQONdY7ZYhl-O8UwwpnpODtxn5fuA4cN3n7bRa2t8u_7_hm-T5ocK</recordid><startdate>201012</startdate><enddate>201012</enddate><creator>Legriel, Stéphane</creator><creator>Azoulay, Elie</creator><creator>Resche-Rigon, Matthieu</creator><creator>Lemiale, Virginie</creator><creator>Mourvillier, Bruno</creator><creator>Kouatchet, Achille</creator><creator>Troché, Gilles</creator><creator>Wolf, Manuel</creator><creator>Galliot, Richard</creator><creator>Dessertaine, Géraldine</creator><creator>Combaux, Danièle</creator><creator>Jacobs, Frederic</creator><creator>Beuret, Pascal</creator><creator>Megarbane, Bruno</creator><creator>Carli, Pierre</creator><creator>Lambert, Yves</creator><creator>Bruneel, Fabrice</creator><creator>Bedos, Jean-Pierre</creator><general>by the Society of Critical Care Medicine and Lippincott Williams & Wilkins</general><general>Lippincott Williams & Wilkins</general><general>Lippincott, Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-2522-2764</orcidid><orcidid>https://orcid.org/0000-0002-8162-1508</orcidid></search><sort><creationdate>201012</creationdate><title>Functional outcome after convulsive status epilepticus</title><author>Legriel, Stéphane ; Azoulay, Elie ; Resche-Rigon, Matthieu ; Lemiale, Virginie ; Mourvillier, Bruno ; Kouatchet, Achille ; Troché, Gilles ; Wolf, Manuel ; Galliot, Richard ; Dessertaine, Géraldine ; Combaux, Danièle ; Jacobs, Frederic ; Beuret, Pascal ; Megarbane, Bruno ; Carli, Pierre ; Lambert, Yves ; Bruneel, Fabrice ; Bedos, Jean-Pierre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4536-ec8d4bfa45eb945119e6b89c655fc92bc0d1f2609875f49c11aca00efccf1c943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Anticonvulsants - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Cardiology and cardiovascular system</topic><topic>Cohort Studies</topic><topic>Confidence Intervals</topic><topic>Critical Care - methods</topic><topic>Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care</topic><topic>Emerging diseases</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glasgow Coma Scale</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Intensive care medicine</topic><topic>Intensive Care Units</topic><topic>Life Sciences</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neuropsychological Tests</topic><topic>Odds Ratio</topic><topic>Prospective Studies</topic><topic>Pulmonology and respiratory tract</topic><topic>Recovery of Function</topic><topic>Respiration, Artificial - methods</topic><topic>Risk Assessment</topic><topic>Severity of Illness Index</topic><topic>Sex Factors</topic><topic>Status Epilepticus - diagnosis</topic><topic>Status Epilepticus - mortality</topic><topic>Status Epilepticus - therapy</topic><topic>Survival Analysis</topic><topic>Tomography, X-Ray Computed</topic><topic>Toxicology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Legriel, Stéphane</creatorcontrib><creatorcontrib>Azoulay, Elie</creatorcontrib><creatorcontrib>Resche-Rigon, Matthieu</creatorcontrib><creatorcontrib>Lemiale, Virginie</creatorcontrib><creatorcontrib>Mourvillier, Bruno</creatorcontrib><creatorcontrib>Kouatchet, Achille</creatorcontrib><creatorcontrib>Troché, Gilles</creatorcontrib><creatorcontrib>Wolf, Manuel</creatorcontrib><creatorcontrib>Galliot, Richard</creatorcontrib><creatorcontrib>Dessertaine, Géraldine</creatorcontrib><creatorcontrib>Combaux, Danièle</creatorcontrib><creatorcontrib>Jacobs, Frederic</creatorcontrib><creatorcontrib>Beuret, Pascal</creatorcontrib><creatorcontrib>Megarbane, Bruno</creatorcontrib><creatorcontrib>Carli, Pierre</creatorcontrib><creatorcontrib>Lambert, Yves</creatorcontrib><creatorcontrib>Bruneel, Fabrice</creatorcontrib><creatorcontrib>Bedos, Jean-Pierre</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Legriel, Stéphane</au><au>Azoulay, Elie</au><au>Resche-Rigon, Matthieu</au><au>Lemiale, Virginie</au><au>Mourvillier, Bruno</au><au>Kouatchet, Achille</au><au>Troché, Gilles</au><au>Wolf, Manuel</au><au>Galliot, Richard</au><au>Dessertaine, Géraldine</au><au>Combaux, Danièle</au><au>Jacobs, Frederic</au><au>Beuret, Pascal</au><au>Megarbane, Bruno</au><au>Carli, Pierre</au><au>Lambert, Yves</au><au>Bruneel, Fabrice</au><au>Bedos, Jean-Pierre</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional outcome after convulsive status epilepticus</atitle><jtitle>Critical care medicine</jtitle><addtitle>Crit Care Med</addtitle><date>2010-12</date><risdate>2010</risdate><volume>38</volume><issue>12</issue><spage>2295</spage><epage>2303</epage><pages>2295-2303</pages><issn>0090-3493</issn><eissn>1530-0293</eissn><coden>CCMDC7</coden><abstract>OBJECTIVES:Few outcome data are available about convulsive status epilepticus managed in the intensive care unit. We studied 90-day functional outcomes and their determinants in patients with convulsive status epilepticus.
DESIGN:Two hundred forty-eight convulsive status epilepticus patients admitted to 18 intensive care units in 2005–2007 were included in a prospective observational cohort study. The main outcome measure was a Glasgow Outcome Scale score of 5 (good recovery) on day 90.
MAIN RESULTS:Convulsive status epilepticus occurred out of hospital in 177 (67%) patients, and all but 15 patients were still seizing at medical team arrival. The median time from convulsive status epilepticus onset to anticonvulsant drug initiation was 40 mins (interquartile range, 5–80). Total seizure duration was 85 mins (interquartile range, 46.5–180). Convulsive status epilepticus was refractory in 49 (20%) patients. The most common causes of convulsive status epilepticus were anticonvulsive agent withdrawal (36.4%) in patients with previous epilepsy and stroke (27.7%) in inaugural convulsive status epilepticus. Mechanical ventilation was needed in 210 (85%) patients. On day 90, 42 (18.8%) patients were dead, 87 (38.8%) had marked functional impairments (Glasgow Outcome Scale score, 2–4), and 95 (42.4%) had a good recovery (Glasgow Outcome Scale score, 5). Factors showing independent positive associations with poor outcome (Glasgow Outcome Scale score, <5) were older age (odds ratio, 1.04/year; 95% confidence interval, 1.02–1.05; p = .0005), cerebral insult (odds ratio, 2.70; 95% confidence interval, 1.37–5.26; p = .007), longer seizure duration (odds ratio, 1.72/120 min; 95% confidence interval, 1.05–2.86; p = .03), on-scene focal neurologic signs (odds ratio, 2.08; 95% confidence interval, 1.03–4.16; p = .04), and refractory convulsive status epilepticus (odds ratio, 2.70; 95% confidence interval, 1.02–7.14; p = .045).
CONCLUSIONS:Ninety days after intensive care unit admission for convulsive status epilepticus, half the survivors had severe functional impairments. Longer seizure duration, cerebral insult, and refractory convulsive status epilepticus were strongly associated with poor outcomes, suggesting a role for early neuroprotective strategies.</abstract><cop>Hagerstown, MD</cop><pub>by the Society of Critical Care Medicine and Lippincott Williams & Wilkins</pub><pmid>20890201</pmid><doi>10.1097/CCM.0b013e3181f859a6</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-2522-2764</orcidid><orcidid>https://orcid.org/0000-0002-8162-1508</orcidid></addata></record> |
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| ispartof | Critical care medicine, 2010-12, Vol.38 (12), p.2295-2303 |
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| subjects | Adult Age Factors Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anticonvulsants - therapeutic use Biological and medical sciences Cardiology and cardiovascular system Cohort Studies Confidence Intervals Critical Care - methods Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care Emerging diseases Female Follow-Up Studies Glasgow Coma Scale Human health and pathology Humans Infectious diseases Intensive care medicine Intensive Care Units Life Sciences Magnetic Resonance Imaging Male Medical sciences Middle Aged Neuropsychological Tests Odds Ratio Prospective Studies Pulmonology and respiratory tract Recovery of Function Respiration, Artificial - methods Risk Assessment Severity of Illness Index Sex Factors Status Epilepticus - diagnosis Status Epilepticus - mortality Status Epilepticus - therapy Survival Analysis Tomography, X-Ray Computed Toxicology Treatment Outcome |
| title | Functional outcome after convulsive status epilepticus |
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