Single-cell RNA-seq-based proteogenomics identifies glioblastoma-specific transposable elements encoding HLA-I-presented peptides

We analyze transposable elements (TEs) in glioblastoma (GBM) patients using a proteogenomic pipeline that combines single-cell transcriptomics, bulk RNA sequencing (RNA-seq) samples from tumors and healthy-tissue cohorts, and immunopeptidomic samples. We thus identify 370 human leukocyte antigen (HL...

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Veröffentlicht in:	Cell reports (Cambridge) 2022-06, Vol.39 (10), p.110916-110916, Article 110916
Hauptverfasser:	Bonté, Pierre-Emmanuel, Arribas, Yago A, Merlotti, Antonela, Carrascal, Montserrat, Zhang, Jiasi Vicky, Zueva, Elina, Binder, Zev A, Alanio, Cécile, Goudot, Christel, Amigorena, Sebastian
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA Transposable Elements - genetics Glioblastoma - genetics Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class II - genetics HLA Antigens - genetics Humans Life Sciences Peptides - genetics Proteogenomics RNA-Seq
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