Cocrystals of Nitrofurantoin: How Coformers Can Modify Its Solubility and Permeability Across Intestinal Cell Monolayers

Solubility and permeability of nitrofurantoin (NITRO) were compared with those of its cocrystals containing isoniazid (ISO), bipyridyl (BIP), or phenanthroline (PHE) as coformers, and their parent mixtures. NITRO dissolution profiles were evaluated via HPLC; we resorted to molecular dynamics (MD) si...

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Veröffentlicht in:	Crystal growth & design 2022-05, Vol.22 (5), p.3090-3106
Hauptverfasser:	Segalina, Alekos, Pavan, Barbara, Ferretti, Valeria, Spizzo, Federico, Botti, Giada, Bianchi, Anna, Pastore, Mariachiara, Dalpiaz, Alessandro
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical Sciences or physical chemistry Theoretical and
Online-Zugang:	Volltext
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