Meningeal macrophages protect against viral neuroinfection

The surface of the central nervous system (CNS) is protected by the meninges, which contain a dense network of meningeal macrophages (MMs). Here, we examined the role of tissue-resident MM in viral infection. MHC-II− MM were abundant neonatally, whereas MHC-II+ MM appeared over time. These barrier m...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2022-11, Vol.55 (11), p.2103-2117.e10
Hauptverfasser:	Rebejac, Julie, Eme-Scolan, Elisa, Arnaud Paroutaud, Laurie, Kharbouche, Sarah, Teleman, Matei, Spinelli, Lionel, Gallo, Emeline, Roussel-Queval, Annie, Zarubica, Ana, Sansoni, Amandine, Bardin, Quentin, Hoest, Philippe, Michallet, Marie-Cécile, Brousse, Carine, Crozat, Karine, Manglani, Monica, Liu, Zhaoyuan, Ginhoux, Florent, McGavern, Dorian B., Dalod, Marc, Malissen, Bernard, Lawrence, Toby, Rua, Rejane
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals brain COVID-19 immunological barrier Immunology Innate immunity interferon LCMV Life Sciences Lipopolysaccharides Lymphocytic Choriomeningitis Lymphocytic choriomeningitis virus - physiology Macrophages Meninges Mice Mice, Inbred C57BL Neurobiology neuroinfection Neurons and Cognition SARS-CoV-2 virus
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