Binding of two zinc ions promotes liquid-liquid phase separation of Tau

Tau is a naturally disordered microtubule associated protein which forms intraneuronal aggregates in several neurodegenerative diseases including Alzheimer's disease (AD). It was reported that zinc interaction with tau protein can trigger its aggregation. Recently we identified three zinc bindi...

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Veröffentlicht in:	International journal of biological macromolecules 2022-12, Vol.223 (Pt A), p.1223-1229
Hauptverfasser:	Yatoui, Dahbia, Tsvetkov, Philipp O., La Rocca, Romain, Baksheeva, Viktoriia E., Allegro, Diane, Breuzard, Gilles, Ferracci, Géraldine, Byrne, Deborah, Devred, François
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregation Alzheimer Disease - metabolism Binding Sites Biochemistry, Molecular Biology Biophysics Cancer Humans Ions Life Sciences Liquid-liquid phase separation Neurobiology Neurodegenerative Diseases - metabolism Neurons and Cognition Tau protein tau Proteins - chemistry Zinc Zinc - pharmacology
Online-Zugang:	Volltext
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