Patient-specific modeling of left ventricle mechanics

We present a computational framework for the study of cardiac motion. The bio-mechanical model captures the passive and active properties of the cardiac tissue as well as the fiber architecture. We focus on the analysis of deformations of a beating left ventricle (LV), comparing numerical simulations with real data acquired by echocardiography. The goal is to determine the clinical relevance of the LV strains pattern and to investigate the relationships between that pattern and the arrangement of myocardial fibers. The proposed framework could in principle be used for a wide range of clinical applications.