Seizures as a complication of recreational drug use: Analysis of the Euro-DEN Plus data-set
•Seizures occurred in 4% of recreational drug presentations to emergency departments.•Fentanyl, synthetic cannabinoids, and MDMA associated with increased seizures.•Seizures after recreational drug use associated with worse clinical outcomes. Seizures are a recognized and potentially serious complic...
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| Veröffentlicht in: | Neurotoxicology (Park Forest South) 2019-07, Vol.73, p.183-187 |
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| creator | Wolfe, Caitlin E. Wood, David M. Dines, Alison Whatley, Benjamin P. Yates, Christopher Heyerdahl, Fridtjof Hovda, Knut Erik Giraudon, Isabelle Dargan, Paul I. Anseeuw, Kurt Badaras, Robertas Bonnici, Jeffrey Brvar, Miran Caganova, Blazena Ceschi, Alessandro Eyer, Florian Galicia, Miguel Geith, Stefanie Gillebeert, Johan Grenc, Damjan Gorozia, Ketevan Jaffal, Karim Jürgens, Gesche Kabata, Piotr Maciej Kennedy, Iarlaith Konstari, Jutta Kutubidze, Soso Laubner, Gabija Liakoni, Evangelia Liechti, Matthias E. Lyphout, Cathelijne Mégarbane, Bruno Miró, Òscar Moughty, Adrian Müller, Laura O'Connor, Niall Paasma, Raido Perez, Juan Ortega Perminas, Marius Persett, Per Sverre Põld, Kristiina Puiguriguer, Jordi Radenkova-Saeva, Julia Rulisek, Jan Schmid, Yasmin Scholz, Irene Sopirala, Radhika Surkus, Jonas Toth, Ibolya Vallersnes, Odd Martin Vigorita, Federico Waldman, Wojciech Waring, W. Stephen Zacharov, Sergej |
| description | •Seizures occurred in 4% of recreational drug presentations to emergency departments.•Fentanyl, synthetic cannabinoids, and MDMA associated with increased seizures.•Seizures after recreational drug use associated with worse clinical outcomes.
Seizures are a recognized and potentially serious complication of recreational drug use. This study examined a large international data set of presentations to Emergency Departments with acute recreational drug toxicity, the European Drug Emergencies Plus (Euro-DEN Plus) Network, to compare presentations with and without seizures and estimate incidence and associated drugs. Amongst 23,947 presentations between January 2014 and December 2017, there were 1013 (4.2%) with reported seizures. Clinical and demographic features were similar between individuals who had a seizure and those who did not, although rates of coma, cardiac arrest, intubation, intensive care admission, and death were significantly higher in those with seizures. There was a significant association between specific drugs and a higher seizure incidence, including fentanyl (odds ratio 2.63, 95% confidence interval 1.20–5.80), and synthetic cannabinoids (OR 2.90, 95% CI 2.19–3.84). Other drugs were associated with a lower seizure incidence, including heroin (OR 0.46, 95% CI 0.35–0.61), clonazepam (OR 0.22, 95% CI 0.06–0.91), and cannabis (OR 0.65, 95% CI 0.50–0.86). This substantiates observations that the synthetic cannabinoids as a group of novel psychoactive substances are clinically different in consequence of intoxication than cannabis, and that individuals who suffer a seizure in the context of recreational drug intoxication are likely to have worse outcomes overall. Utilising this information of what substances have a greater risk of seizures, could provide tailored harm reduction and education strategies to users to reduce the risk of seizures and their associated complications. |
| doi_str_mv | 10.1016/j.neuro.2019.04.003 |
| format | Article |
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Seizures are a recognized and potentially serious complication of recreational drug use. This study examined a large international data set of presentations to Emergency Departments with acute recreational drug toxicity, the European Drug Emergencies Plus (Euro-DEN Plus) Network, to compare presentations with and without seizures and estimate incidence and associated drugs. Amongst 23,947 presentations between January 2014 and December 2017, there were 1013 (4.2%) with reported seizures. Clinical and demographic features were similar between individuals who had a seizure and those who did not, although rates of coma, cardiac arrest, intubation, intensive care admission, and death were significantly higher in those with seizures. There was a significant association between specific drugs and a higher seizure incidence, including fentanyl (odds ratio 2.63, 95% confidence interval 1.20–5.80), and synthetic cannabinoids (OR 2.90, 95% CI 2.19–3.84). Other drugs were associated with a lower seizure incidence, including heroin (OR 0.46, 95% CI 0.35–0.61), clonazepam (OR 0.22, 95% CI 0.06–0.91), and cannabis (OR 0.65, 95% CI 0.50–0.86). This substantiates observations that the synthetic cannabinoids as a group of novel psychoactive substances are clinically different in consequence of intoxication than cannabis, and that individuals who suffer a seizure in the context of recreational drug intoxication are likely to have worse outcomes overall. Utilising this information of what substances have a greater risk of seizures, could provide tailored harm reduction and education strategies to users to reduce the risk of seizures and their associated complications.</description><identifier>ISSN: 0161-813X</identifier><identifier>EISSN: 1872-9711</identifier><identifier>DOI: 10.1016/j.neuro.2019.04.003</identifier><identifier>PMID: 30974132</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Acute toxicity ; Adult ; Body Temperature - drug effects ; Cannabinoids ; Cannabinoids - adverse effects ; Cannabinoids - chemical synthesis ; Cannabis ; Cardiology and cardiovascular system ; Clonazepam ; Coma ; Complications ; Confidence intervals ; Datasets ; Demographics ; Drug abuse ; Drug use ; Drugs ; Emerging diseases ; Europe - epidemiology ; Female ; Fentanyl ; Hemodynamics - drug effects ; Heroin ; Human health and pathology ; Humans ; Illicit Drugs - adverse effects ; Illicit Drugs - chemical synthesis ; Incidence ; Infectious diseases ; Intoxication ; Intubation ; Life Sciences ; Male ; Narcotic Antagonists - adverse effects ; New psychoactive substances ; Opioid-Related Disorders - epidemiology ; Prognosis ; Psychotropic Drugs - adverse effects ; Psychotropic Drugs - chemical synthesis ; Pulmonology and respiratory tract ; Recreational drug ; Recreational use ; Respiration - drug effects ; Risk Assessment ; Risk Factors ; Seizure ; Seizures ; Seizures - chemically induced ; Seizures - diagnosis ; Seizures - epidemiology ; Seizures - physiopathology ; Substance-Related Disorders - diagnosis ; Substance-Related Disorders - epidemiology ; Substance-Related Disorders - physiopathology ; Synthetic cannabinoid ; Toxicity ; Toxicology</subject><ispartof>Neurotoxicology (Park Forest South), 2019-07, Vol.73, p.183-187</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright © 2019 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier BV Jul 2019</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-56b36e106cad9c79ce1638be5140a1072622a3d635a279168e87791853b16ec73</citedby><cites>FETCH-LOGICAL-c447t-56b36e106cad9c79ce1638be5140a1072622a3d635a279168e87791853b16ec73</cites><orcidid>0000-0002-2522-2764</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0161813X19300324$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30974132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03859994$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Wolfe, Caitlin E.</creatorcontrib><creatorcontrib>Wood, David M.</creatorcontrib><creatorcontrib>Dines, Alison</creatorcontrib><creatorcontrib>Whatley, Benjamin P.</creatorcontrib><creatorcontrib>Yates, Christopher</creatorcontrib><creatorcontrib>Heyerdahl, Fridtjof</creatorcontrib><creatorcontrib>Hovda, Knut Erik</creatorcontrib><creatorcontrib>Giraudon, Isabelle</creatorcontrib><creatorcontrib>Dargan, Paul I.</creatorcontrib><creatorcontrib>Anseeuw, Kurt</creatorcontrib><creatorcontrib>Badaras, Robertas</creatorcontrib><creatorcontrib>Bonnici, Jeffrey</creatorcontrib><creatorcontrib>Brvar, Miran</creatorcontrib><creatorcontrib>Caganova, Blazena</creatorcontrib><creatorcontrib>Ceschi, Alessandro</creatorcontrib><creatorcontrib>Eyer, Florian</creatorcontrib><creatorcontrib>Galicia, Miguel</creatorcontrib><creatorcontrib>Geith, Stefanie</creatorcontrib><creatorcontrib>Gillebeert, Johan</creatorcontrib><creatorcontrib>Grenc, Damjan</creatorcontrib><creatorcontrib>Gorozia, Ketevan</creatorcontrib><creatorcontrib>Jaffal, Karim</creatorcontrib><creatorcontrib>Jürgens, Gesche</creatorcontrib><creatorcontrib>Kabata, Piotr Maciej</creatorcontrib><creatorcontrib>Kennedy, Iarlaith</creatorcontrib><creatorcontrib>Konstari, Jutta</creatorcontrib><creatorcontrib>Kutubidze, Soso</creatorcontrib><creatorcontrib>Laubner, Gabija</creatorcontrib><creatorcontrib>Liakoni, Evangelia</creatorcontrib><creatorcontrib>Liechti, Matthias E.</creatorcontrib><creatorcontrib>Lyphout, Cathelijne</creatorcontrib><creatorcontrib>Mégarbane, Bruno</creatorcontrib><creatorcontrib>Miró, Òscar</creatorcontrib><creatorcontrib>Moughty, Adrian</creatorcontrib><creatorcontrib>Müller, Laura</creatorcontrib><creatorcontrib>O'Connor, Niall</creatorcontrib><creatorcontrib>Paasma, Raido</creatorcontrib><creatorcontrib>Perez, Juan Ortega</creatorcontrib><creatorcontrib>Perminas, Marius</creatorcontrib><creatorcontrib>Persett, Per Sverre</creatorcontrib><creatorcontrib>Põld, Kristiina</creatorcontrib><creatorcontrib>Puiguriguer, Jordi</creatorcontrib><creatorcontrib>Radenkova-Saeva, Julia</creatorcontrib><creatorcontrib>Rulisek, Jan</creatorcontrib><creatorcontrib>Schmid, Yasmin</creatorcontrib><creatorcontrib>Scholz, Irene</creatorcontrib><creatorcontrib>Sopirala, Radhika</creatorcontrib><creatorcontrib>Surkus, Jonas</creatorcontrib><creatorcontrib>Toth, Ibolya</creatorcontrib><creatorcontrib>Vallersnes, Odd Martin</creatorcontrib><creatorcontrib>Vigorita, Federico</creatorcontrib><creatorcontrib>Waldman, Wojciech</creatorcontrib><creatorcontrib>Waring, W. Stephen</creatorcontrib><creatorcontrib>Zacharov, Sergej</creatorcontrib><creatorcontrib>Euro-DEN Research Group</creatorcontrib><title>Seizures as a complication of recreational drug use: Analysis of the Euro-DEN Plus data-set</title><title>Neurotoxicology (Park Forest South)</title><addtitle>Neurotoxicology</addtitle><description>•Seizures occurred in 4% of recreational drug presentations to emergency departments.•Fentanyl, synthetic cannabinoids, and MDMA associated with increased seizures.•Seizures after recreational drug use associated with worse clinical outcomes.
Seizures are a recognized and potentially serious complication of recreational drug use. This study examined a large international data set of presentations to Emergency Departments with acute recreational drug toxicity, the European Drug Emergencies Plus (Euro-DEN Plus) Network, to compare presentations with and without seizures and estimate incidence and associated drugs. Amongst 23,947 presentations between January 2014 and December 2017, there were 1013 (4.2%) with reported seizures. Clinical and demographic features were similar between individuals who had a seizure and those who did not, although rates of coma, cardiac arrest, intubation, intensive care admission, and death were significantly higher in those with seizures. There was a significant association between specific drugs and a higher seizure incidence, including fentanyl (odds ratio 2.63, 95% confidence interval 1.20–5.80), and synthetic cannabinoids (OR 2.90, 95% CI 2.19–3.84). Other drugs were associated with a lower seizure incidence, including heroin (OR 0.46, 95% CI 0.35–0.61), clonazepam (OR 0.22, 95% CI 0.06–0.91), and cannabis (OR 0.65, 95% CI 0.50–0.86). This substantiates observations that the synthetic cannabinoids as a group of novel psychoactive substances are clinically different in consequence of intoxication than cannabis, and that individuals who suffer a seizure in the context of recreational drug intoxication are likely to have worse outcomes overall. Utilising this information of what substances have a greater risk of seizures, could provide tailored harm reduction and education strategies to users to reduce the risk of seizures and their associated complications.</description><subject>Acute toxicity</subject><subject>Adult</subject><subject>Body Temperature - drug effects</subject><subject>Cannabinoids</subject><subject>Cannabinoids - adverse effects</subject><subject>Cannabinoids - chemical synthesis</subject><subject>Cannabis</subject><subject>Cardiology and cardiovascular system</subject><subject>Clonazepam</subject><subject>Coma</subject><subject>Complications</subject><subject>Confidence intervals</subject><subject>Datasets</subject><subject>Demographics</subject><subject>Drug abuse</subject><subject>Drug use</subject><subject>Drugs</subject><subject>Emerging diseases</subject><subject>Europe - epidemiology</subject><subject>Female</subject><subject>Fentanyl</subject><subject>Hemodynamics - drug effects</subject><subject>Heroin</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Illicit Drugs - adverse effects</subject><subject>Illicit Drugs - chemical synthesis</subject><subject>Incidence</subject><subject>Infectious diseases</subject><subject>Intoxication</subject><subject>Intubation</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Narcotic Antagonists - adverse effects</subject><subject>New psychoactive substances</subject><subject>Opioid-Related Disorders - epidemiology</subject><subject>Prognosis</subject><subject>Psychotropic Drugs - adverse effects</subject><subject>Psychotropic Drugs - chemical synthesis</subject><subject>Pulmonology and respiratory tract</subject><subject>Recreational drug</subject><subject>Recreational use</subject><subject>Respiration - drug effects</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Seizure</subject><subject>Seizures</subject><subject>Seizures - chemically induced</subject><subject>Seizures - diagnosis</subject><subject>Seizures - epidemiology</subject><subject>Seizures - physiopathology</subject><subject>Substance-Related Disorders - diagnosis</subject><subject>Substance-Related Disorders - epidemiology</subject><subject>Substance-Related Disorders - physiopathology</subject><subject>Synthetic cannabinoid</subject><subject>Toxicity</subject><subject>Toxicology</subject><issn>0161-813X</issn><issn>1872-9711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kVtrFDEUgIModm39BYIEfKkPM-YkM7kIPiztaoVFCyoIPoRs5qzNMrtZk5lC--ub6dY--CAEDid855J8hLwCVgMD-W5T73BMseYMTM2amjHxhMxAK14ZBfCUzAoFlQbx84i8yHnDGLRKmufkSDCjGhB8Rn59w3A7JszUlUN93O774N0Q4o7GNU3oE95nrqddGn_TMeN7Oi_pTQ55QoYrpIuyR3W--EIv-zHTzg2uyjickGdr12d8-RCPyY-Pi-9nF9Xy66fPZ_Nl5ZtGDVUrV0IiMOldZ7wyHkEKvcIWGuaAKS45d6KTonVcGZAatSpRt2IFEr0Sx-Ttoe-V6-0-ha1LNza6YC_mSzvdMaFbY0xzDYU9PbD7FP-MmAe7Ddlj37sdxjFbzpmRjCuY2r75B93EMZWXT5TUUvOm0YUSB8qnmHPC9eMGwOzkyW7svSc7ebKsscVTqXr90HtcbbF7rPkrpgAfDgCWj7sOmGz2AXceu1CcDLaL4b8D7gCwkaGM</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Wolfe, Caitlin E.</creator><creator>Wood, David M.</creator><creator>Dines, Alison</creator><creator>Whatley, Benjamin P.</creator><creator>Yates, Christopher</creator><creator>Heyerdahl, Fridtjof</creator><creator>Hovda, Knut Erik</creator><creator>Giraudon, Isabelle</creator><creator>Dargan, Paul I.</creator><creator>Anseeuw, Kurt</creator><creator>Badaras, Robertas</creator><creator>Bonnici, Jeffrey</creator><creator>Brvar, Miran</creator><creator>Caganova, Blazena</creator><creator>Ceschi, Alessandro</creator><creator>Eyer, Florian</creator><creator>Galicia, Miguel</creator><creator>Geith, Stefanie</creator><creator>Gillebeert, Johan</creator><creator>Grenc, Damjan</creator><creator>Gorozia, Ketevan</creator><creator>Jaffal, Karim</creator><creator>Jürgens, Gesche</creator><creator>Kabata, Piotr Maciej</creator><creator>Kennedy, Iarlaith</creator><creator>Konstari, Jutta</creator><creator>Kutubidze, Soso</creator><creator>Laubner, Gabija</creator><creator>Liakoni, Evangelia</creator><creator>Liechti, Matthias E.</creator><creator>Lyphout, Cathelijne</creator><creator>Mégarbane, Bruno</creator><creator>Miró, Òscar</creator><creator>Moughty, Adrian</creator><creator>Müller, Laura</creator><creator>O'Connor, Niall</creator><creator>Paasma, Raido</creator><creator>Perez, Juan Ortega</creator><creator>Perminas, Marius</creator><creator>Persett, Per Sverre</creator><creator>Põld, Kristiina</creator><creator>Puiguriguer, Jordi</creator><creator>Radenkova-Saeva, Julia</creator><creator>Rulisek, Jan</creator><creator>Schmid, Yasmin</creator><creator>Scholz, Irene</creator><creator>Sopirala, Radhika</creator><creator>Surkus, Jonas</creator><creator>Toth, Ibolya</creator><creator>Vallersnes, Odd Martin</creator><creator>Vigorita, Federico</creator><creator>Waldman, Wojciech</creator><creator>Waring, W. Stephen</creator><creator>Zacharov, Sergej</creator><general>Elsevier B.V</general><general>Elsevier BV</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-2522-2764</orcidid></search><sort><creationdate>20190701</creationdate><title>Seizures as a complication of recreational drug use: Analysis of the Euro-DEN Plus data-set</title><author>Wolfe, Caitlin E. ; Wood, David M. ; Dines, Alison ; Whatley, Benjamin P. ; Yates, Christopher ; Heyerdahl, Fridtjof ; Hovda, Knut Erik ; Giraudon, Isabelle ; Dargan, Paul I. ; Anseeuw, Kurt ; Badaras, Robertas ; Bonnici, Jeffrey ; Brvar, Miran ; Caganova, Blazena ; Ceschi, Alessandro ; Eyer, Florian ; Galicia, Miguel ; Geith, Stefanie ; Gillebeert, Johan ; Grenc, Damjan ; Gorozia, Ketevan ; Jaffal, Karim ; Jürgens, Gesche ; Kabata, Piotr Maciej ; Kennedy, Iarlaith ; Konstari, Jutta ; Kutubidze, Soso ; Laubner, Gabija ; Liakoni, Evangelia ; Liechti, Matthias E. ; Lyphout, Cathelijne ; Mégarbane, Bruno ; Miró, Òscar ; Moughty, Adrian ; Müller, Laura ; O'Connor, Niall ; Paasma, Raido ; Perez, Juan Ortega ; Perminas, Marius ; Persett, Per Sverre ; Põld, Kristiina ; Puiguriguer, Jordi ; Radenkova-Saeva, Julia ; Rulisek, Jan ; Schmid, Yasmin ; Scholz, Irene ; Sopirala, Radhika ; Surkus, Jonas ; Toth, Ibolya ; Vallersnes, Odd Martin ; Vigorita, Federico ; Waldman, Wojciech ; Waring, W. Stephen ; Zacharov, Sergej</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-56b36e106cad9c79ce1638be5140a1072622a3d635a279168e87791853b16ec73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acute toxicity</topic><topic>Adult</topic><topic>Body Temperature - drug effects</topic><topic>Cannabinoids</topic><topic>Cannabinoids - adverse effects</topic><topic>Cannabinoids - chemical synthesis</topic><topic>Cannabis</topic><topic>Cardiology and cardiovascular system</topic><topic>Clonazepam</topic><topic>Coma</topic><topic>Complications</topic><topic>Confidence intervals</topic><topic>Datasets</topic><topic>Demographics</topic><topic>Drug abuse</topic><topic>Drug use</topic><topic>Drugs</topic><topic>Emerging diseases</topic><topic>Europe - epidemiology</topic><topic>Female</topic><topic>Fentanyl</topic><topic>Hemodynamics - drug effects</topic><topic>Heroin</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Illicit Drugs - adverse effects</topic><topic>Illicit Drugs - chemical synthesis</topic><topic>Incidence</topic><topic>Infectious diseases</topic><topic>Intoxication</topic><topic>Intubation</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Narcotic Antagonists - adverse effects</topic><topic>New psychoactive substances</topic><topic>Opioid-Related Disorders - epidemiology</topic><topic>Prognosis</topic><topic>Psychotropic Drugs - adverse effects</topic><topic>Psychotropic Drugs - chemical synthesis</topic><topic>Pulmonology and respiratory tract</topic><topic>Recreational drug</topic><topic>Recreational use</topic><topic>Respiration - drug effects</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Seizure</topic><topic>Seizures</topic><topic>Seizures - chemically induced</topic><topic>Seizures - diagnosis</topic><topic>Seizures - epidemiology</topic><topic>Seizures - physiopathology</topic><topic>Substance-Related Disorders - diagnosis</topic><topic>Substance-Related Disorders - epidemiology</topic><topic>Substance-Related Disorders - physiopathology</topic><topic>Synthetic cannabinoid</topic><topic>Toxicity</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wolfe, Caitlin E.</creatorcontrib><creatorcontrib>Wood, David M.</creatorcontrib><creatorcontrib>Dines, Alison</creatorcontrib><creatorcontrib>Whatley, Benjamin P.</creatorcontrib><creatorcontrib>Yates, Christopher</creatorcontrib><creatorcontrib>Heyerdahl, Fridtjof</creatorcontrib><creatorcontrib>Hovda, Knut Erik</creatorcontrib><creatorcontrib>Giraudon, Isabelle</creatorcontrib><creatorcontrib>Dargan, Paul I.</creatorcontrib><creatorcontrib>Anseeuw, Kurt</creatorcontrib><creatorcontrib>Badaras, Robertas</creatorcontrib><creatorcontrib>Bonnici, Jeffrey</creatorcontrib><creatorcontrib>Brvar, Miran</creatorcontrib><creatorcontrib>Caganova, Blazena</creatorcontrib><creatorcontrib>Ceschi, Alessandro</creatorcontrib><creatorcontrib>Eyer, Florian</creatorcontrib><creatorcontrib>Galicia, Miguel</creatorcontrib><creatorcontrib>Geith, Stefanie</creatorcontrib><creatorcontrib>Gillebeert, Johan</creatorcontrib><creatorcontrib>Grenc, Damjan</creatorcontrib><creatorcontrib>Gorozia, Ketevan</creatorcontrib><creatorcontrib>Jaffal, Karim</creatorcontrib><creatorcontrib>Jürgens, Gesche</creatorcontrib><creatorcontrib>Kabata, Piotr Maciej</creatorcontrib><creatorcontrib>Kennedy, Iarlaith</creatorcontrib><creatorcontrib>Konstari, Jutta</creatorcontrib><creatorcontrib>Kutubidze, Soso</creatorcontrib><creatorcontrib>Laubner, Gabija</creatorcontrib><creatorcontrib>Liakoni, Evangelia</creatorcontrib><creatorcontrib>Liechti, Matthias E.</creatorcontrib><creatorcontrib>Lyphout, Cathelijne</creatorcontrib><creatorcontrib>Mégarbane, Bruno</creatorcontrib><creatorcontrib>Miró, Òscar</creatorcontrib><creatorcontrib>Moughty, Adrian</creatorcontrib><creatorcontrib>Müller, Laura</creatorcontrib><creatorcontrib>O'Connor, Niall</creatorcontrib><creatorcontrib>Paasma, Raido</creatorcontrib><creatorcontrib>Perez, Juan Ortega</creatorcontrib><creatorcontrib>Perminas, Marius</creatorcontrib><creatorcontrib>Persett, Per Sverre</creatorcontrib><creatorcontrib>Põld, Kristiina</creatorcontrib><creatorcontrib>Puiguriguer, Jordi</creatorcontrib><creatorcontrib>Radenkova-Saeva, Julia</creatorcontrib><creatorcontrib>Rulisek, Jan</creatorcontrib><creatorcontrib>Schmid, Yasmin</creatorcontrib><creatorcontrib>Scholz, Irene</creatorcontrib><creatorcontrib>Sopirala, Radhika</creatorcontrib><creatorcontrib>Surkus, Jonas</creatorcontrib><creatorcontrib>Toth, Ibolya</creatorcontrib><creatorcontrib>Vallersnes, Odd Martin</creatorcontrib><creatorcontrib>Vigorita, Federico</creatorcontrib><creatorcontrib>Waldman, Wojciech</creatorcontrib><creatorcontrib>Waring, W. Stephen</creatorcontrib><creatorcontrib>Zacharov, Sergej</creatorcontrib><creatorcontrib>Euro-DEN Research Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Neurotoxicology (Park Forest South)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wolfe, Caitlin E.</au><au>Wood, David M.</au><au>Dines, Alison</au><au>Whatley, Benjamin P.</au><au>Yates, Christopher</au><au>Heyerdahl, Fridtjof</au><au>Hovda, Knut Erik</au><au>Giraudon, Isabelle</au><au>Dargan, Paul I.</au><au>Anseeuw, Kurt</au><au>Badaras, Robertas</au><au>Bonnici, Jeffrey</au><au>Brvar, Miran</au><au>Caganova, Blazena</au><au>Ceschi, Alessandro</au><au>Eyer, Florian</au><au>Galicia, Miguel</au><au>Geith, Stefanie</au><au>Gillebeert, Johan</au><au>Grenc, Damjan</au><au>Gorozia, Ketevan</au><au>Jaffal, Karim</au><au>Jürgens, Gesche</au><au>Kabata, Piotr Maciej</au><au>Kennedy, Iarlaith</au><au>Konstari, Jutta</au><au>Kutubidze, Soso</au><au>Laubner, Gabija</au><au>Liakoni, Evangelia</au><au>Liechti, Matthias E.</au><au>Lyphout, Cathelijne</au><au>Mégarbane, Bruno</au><au>Miró, Òscar</au><au>Moughty, Adrian</au><au>Müller, Laura</au><au>O'Connor, Niall</au><au>Paasma, Raido</au><au>Perez, Juan Ortega</au><au>Perminas, Marius</au><au>Persett, Per Sverre</au><au>Põld, Kristiina</au><au>Puiguriguer, Jordi</au><au>Radenkova-Saeva, Julia</au><au>Rulisek, Jan</au><au>Schmid, Yasmin</au><au>Scholz, Irene</au><au>Sopirala, Radhika</au><au>Surkus, Jonas</au><au>Toth, Ibolya</au><au>Vallersnes, Odd Martin</au><au>Vigorita, Federico</au><au>Waldman, Wojciech</au><au>Waring, W. Stephen</au><au>Zacharov, Sergej</au><aucorp>Euro-DEN Research Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Seizures as a complication of recreational drug use: Analysis of the Euro-DEN Plus data-set</atitle><jtitle>Neurotoxicology (Park Forest South)</jtitle><addtitle>Neurotoxicology</addtitle><date>2019-07-01</date><risdate>2019</risdate><volume>73</volume><spage>183</spage><epage>187</epage><pages>183-187</pages><issn>0161-813X</issn><eissn>1872-9711</eissn><abstract>•Seizures occurred in 4% of recreational drug presentations to emergency departments.•Fentanyl, synthetic cannabinoids, and MDMA associated with increased seizures.•Seizures after recreational drug use associated with worse clinical outcomes.
Seizures are a recognized and potentially serious complication of recreational drug use. This study examined a large international data set of presentations to Emergency Departments with acute recreational drug toxicity, the European Drug Emergencies Plus (Euro-DEN Plus) Network, to compare presentations with and without seizures and estimate incidence and associated drugs. Amongst 23,947 presentations between January 2014 and December 2017, there were 1013 (4.2%) with reported seizures. Clinical and demographic features were similar between individuals who had a seizure and those who did not, although rates of coma, cardiac arrest, intubation, intensive care admission, and death were significantly higher in those with seizures. There was a significant association between specific drugs and a higher seizure incidence, including fentanyl (odds ratio 2.63, 95% confidence interval 1.20–5.80), and synthetic cannabinoids (OR 2.90, 95% CI 2.19–3.84). Other drugs were associated with a lower seizure incidence, including heroin (OR 0.46, 95% CI 0.35–0.61), clonazepam (OR 0.22, 95% CI 0.06–0.91), and cannabis (OR 0.65, 95% CI 0.50–0.86). This substantiates observations that the synthetic cannabinoids as a group of novel psychoactive substances are clinically different in consequence of intoxication than cannabis, and that individuals who suffer a seizure in the context of recreational drug intoxication are likely to have worse outcomes overall. Utilising this information of what substances have a greater risk of seizures, could provide tailored harm reduction and education strategies to users to reduce the risk of seizures and their associated complications.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>30974132</pmid><doi>10.1016/j.neuro.2019.04.003</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-2522-2764</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0161-813X |
| ispartof | Neurotoxicology (Park Forest South), 2019-07, Vol.73, p.183-187 |
| issn | 0161-813X 1872-9711 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_03859994v1 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acute toxicity Adult Body Temperature - drug effects Cannabinoids Cannabinoids - adverse effects Cannabinoids - chemical synthesis Cannabis Cardiology and cardiovascular system Clonazepam Coma Complications Confidence intervals Datasets Demographics Drug abuse Drug use Drugs Emerging diseases Europe - epidemiology Female Fentanyl Hemodynamics - drug effects Heroin Human health and pathology Humans Illicit Drugs - adverse effects Illicit Drugs - chemical synthesis Incidence Infectious diseases Intoxication Intubation Life Sciences Male Narcotic Antagonists - adverse effects New psychoactive substances Opioid-Related Disorders - epidemiology Prognosis Psychotropic Drugs - adverse effects Psychotropic Drugs - chemical synthesis Pulmonology and respiratory tract Recreational drug Recreational use Respiration - drug effects Risk Assessment Risk Factors Seizure Seizures Seizures - chemically induced Seizures - diagnosis Seizures - epidemiology Seizures - physiopathology Substance-Related Disorders - diagnosis Substance-Related Disorders - epidemiology Substance-Related Disorders - physiopathology Synthetic cannabinoid Toxicity Toxicology |
| title | Seizures as a complication of recreational drug use: Analysis of the Euro-DEN Plus data-set |
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