Reduced Connexin43 expression limits neointima formation after balloon distension injury in hypercholesterolemic mice

Reducing the expression of the gap junction protein connexin43 (Cx43) inhibits the progression of atherosclerosis, a chronic inflammatory disease. Furthermore, acute vascular injury induced by percutaneous coronary interventions is associated with increased Cx43 expression in neointimal smooth muscl...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2006-06, Vol.113 (24), p.2835-2843
Hauptverfasser:	CHADJICHRISTOS, Christos E, MATTER, Christian M, ROTH, Isabelle, SUTTER, Esther, PELLI, Graziano, LÜSCHER, Thomas F, CHANSON, Marc, KWAK, Brenda R
Format:	Artikel
Sprache:	eng
Schlagworte:	Angioplasty, Balloon - adverse effects Animals Antihypertensive agents Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular system Carotid Artery Diseases - etiology Carotid Artery Diseases - therapy Carotid Stenosis - etiology Carotid Stenosis - prevention & control Cell Division Cell Movement Cells, Cultured - secretion Chemotactic Factors - secretion Cholesterol - blood Connexin 43 - genetics Connexin 43 - physiology Diet, Atherogenic Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous DNA Replication Endothelium, Vascular - pathology Human health and pathology Hyperlipoproteinemia Type II - blood Hyperlipoproteinemia Type II - complications Hyperlipoproteinemia Type II - genetics Hyperplasia Life Sciences Macrophages - pathology Macrophages - secretion Macrophages, Peritoneal - secretion Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Muscle, Smooth, Vascular - pathology Pharmacology. Drug treatments Receptors, LDL - deficiency Receptors, LDL - genetics Recurrence Triglycerides - blood Tunica Intima - pathology
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