Sox9/Sox6 and Sp1 are involved in the insulin-like growth factor-I-mediated upregulation of human type II collagen gene expression in articular chondrocytes

Type II collagen is a marker of articular cartilage encoded by the COL2A1 gene. The nature of the trans factors involved in the upregulation of this gene by insulin-like growth factor-I (IGF-I) remains unclear. We found that IGF-I increased type II collagen synthesis by a transcriptional control mec...

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Veröffentlicht in:	Journal of molecular medicine (Berlin, Germany) Germany), 2012-06, Vol.90 (6), p.649-666
Hauptverfasser:	Renard, Emmanuelle, Porée, Benoît, Chadjichristos, Christos, Kypriotou, Magdalini, Maneix, Laure, Bigot, Nicolas, Legendre, Florence, Ollitrault, David, De Crombrugghe, Benoît, Malléin-Gérin, Frédéric, Moslemi, Safa, Demoor, Magali, Boumediene, Karim, Galéra, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Blotting, Western Cartilage, Articular - metabolism Cells, Cultured Chondrocytes - metabolism Collagen Type II - genetics Collagen Type II - metabolism Gene Expression Regulation Human Genetics Human health and pathology Humans Immunoglobulins - genetics Immunoglobulins - metabolism Insulin-Like Growth Factor I - metabolism Internal Medicine Life Sciences Molecular Medicine Original Article Polymerase Chain Reaction Rabbits SOX9 Transcription Factor - genetics SOX9 Transcription Factor - metabolism SOXD Transcription Factors - genetics SOXD Transcription Factors - metabolism Up-Regulation
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