Cardiac Outcomes in Adults With Mitochondrial Diseases
Patients with mitochondrial diseases are at risk of heart failure (HF) and arrhythmic major adverse cardiac events (MACE). We developed prediction models to estimate the risk of HF and arrhythmic MACE in this population. We determined the incidence and searched for predictors of HF and arrhythmic MA...
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| Veröffentlicht in: | Journal of the American College of Cardiology 2022-10, Vol.80 (15), p.1421-1430 |
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| creator | Savvatis, Konstantinos Vissing, Christoffer Rasmus Klouvi, Lori Florian, Anca Rahman, Mehjabin Béhin, Anthony Fayssoil, Abdallah Masingue, Marion Stojkovic, Tanya Bécane, Henri Marc Berber, Nawal Mochel, Fanny Duboc, Denis Fontaine, Bertrand Krett, Bjørg Stalens, Caroline Lejeune, Julie Pitceathly, Robert D S Lopes, Luis Saadi, Malika Gossios, Thomas Procaccio, Vincent Spinazzi, Marco Tard, Céline De Groote, Pascal Dhaenens, Claire-Marie Douillard, Claire Echaniz-Laguna, Andoni Quinlivan, Ros Hanna, Michael G Yilmaz, Ali Vissing, John Laforêt, Pascal Elliott, Perry Wahbi, Karim |
| description | Patients with mitochondrial diseases are at risk of heart failure (HF) and arrhythmic major adverse cardiac events (MACE).
We developed prediction models to estimate the risk of HF and arrhythmic MACE in this population.
We determined the incidence and searched for predictors of HF and arrhythmic MACE using Cox regression in 600 adult patients from a multicenter registry with genetically confirmed mitochondrial diseases.
Over a median follow-up time of 6.67 years, 29 patients (4.9%) reached the HF endpoint, including 19 hospitalizations for nonterminal HF, 2 cardiac transplantations, and 8 deaths from HF. Thirty others (5.1%) reached the arrhythmic MACE, including 21 with third-degree or type II second-degree atrioventricular blocks, 4 with sinus node dysfunction, and 5 sudden cardiac deaths. Predictors of HF were the m.3243A>G variant (HR: 4.3; 95% CI: 1.8-10.1), conduction defects (HR: 3.0; 95% CI: 1.3-6.9), left ventricular (LV) hypertrophy (HR: 2.6; 95% CI: 1.1-5.8), LV ejection fraction |
| doi_str_mv | 10.1016/j.jacc.2022.08.716 |
| format | Article |
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We developed prediction models to estimate the risk of HF and arrhythmic MACE in this population.
We determined the incidence and searched for predictors of HF and arrhythmic MACE using Cox regression in 600 adult patients from a multicenter registry with genetically confirmed mitochondrial diseases.
Over a median follow-up time of 6.67 years, 29 patients (4.9%) reached the HF endpoint, including 19 hospitalizations for nonterminal HF, 2 cardiac transplantations, and 8 deaths from HF. Thirty others (5.1%) reached the arrhythmic MACE, including 21 with third-degree or type II second-degree atrioventricular blocks, 4 with sinus node dysfunction, and 5 sudden cardiac deaths. Predictors of HF were the m.3243A>G variant (HR: 4.3; 95% CI: 1.8-10.1), conduction defects (HR: 3.0; 95% CI: 1.3-6.9), left ventricular (LV) hypertrophy (HR: 2.6; 95% CI: 1.1-5.8), LV ejection fraction <50% (HR: 10.2; 95% CI: 4.6-22.3), and premature ventricular beats (HR: 4.1; 95% CI: 1.7-9.9). Independent predictors for arrhythmia were single, large-scale mtDNA deletions (HR: 4.3; 95% CI: 1.7-10.4), conduction defects (HR: 6.8; 95% CI: 3.0-15.4), and LV ejection fraction <50% (HR: 2.7; 95% CI: 1.1-7.1). C-indexes of the Cox regression models were 0.91 (95% CI: 0.88-0.95) and 0.80 (95% CI: 0.70-0.90) for the HF and arrhythmic MACE, respectively.
We developed the first prediction models for HF and arrhythmic MACE in patients with mitochondrial diseases using genetic variant type and simple cardiac assessments.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2022.08.716</identifier><identifier>PMID: 36202532</identifier><language>eng</language><publisher>United States: Elsevier</publisher><subject>Adult ; DNA, Mitochondrial - genetics ; Heart ; Heart Failure - epidemiology ; Humans ; Hypertrophy, Left Ventricular ; Life Sciences ; Mitochondrial Diseases - complications ; Mitochondrial Diseases - epidemiology ; Mitochondrial Diseases - genetics ; Prognosis ; Risk Factors ; Stroke Volume ; Ventricular Function, Left</subject><ispartof>Journal of the American College of Cardiology, 2022-10, Vol.80 (15), p.1421-1430</ispartof><rights>Copyright © 2022 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-c607f19dbb3ecbeaef59fccb803d8e45a041ddd8e048606266b6dd555881f1ec3</citedby><cites>FETCH-LOGICAL-c381t-c607f19dbb3ecbeaef59fccb803d8e45a041ddd8e048606266b6dd555881f1ec3</cites><orcidid>0000-0003-1966-1880 ; 0000-0003-3383-3984 ; 0000-0002-6123-4551 ; 0000-0001-6260-9813 ; 0000-0003-3844-5438 ; 0000-0002-6408-4667 ; 0000-0002-0834-206X ; 0000-0002-4054-2838 ; 0000-0003-0048-9558</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36202532$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03837169$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Savvatis, Konstantinos</creatorcontrib><creatorcontrib>Vissing, Christoffer Rasmus</creatorcontrib><creatorcontrib>Klouvi, Lori</creatorcontrib><creatorcontrib>Florian, Anca</creatorcontrib><creatorcontrib>Rahman, Mehjabin</creatorcontrib><creatorcontrib>Béhin, Anthony</creatorcontrib><creatorcontrib>Fayssoil, Abdallah</creatorcontrib><creatorcontrib>Masingue, Marion</creatorcontrib><creatorcontrib>Stojkovic, Tanya</creatorcontrib><creatorcontrib>Bécane, Henri Marc</creatorcontrib><creatorcontrib>Berber, Nawal</creatorcontrib><creatorcontrib>Mochel, Fanny</creatorcontrib><creatorcontrib>Duboc, Denis</creatorcontrib><creatorcontrib>Fontaine, Bertrand</creatorcontrib><creatorcontrib>Krett, Bjørg</creatorcontrib><creatorcontrib>Stalens, Caroline</creatorcontrib><creatorcontrib>Lejeune, Julie</creatorcontrib><creatorcontrib>Pitceathly, Robert D S</creatorcontrib><creatorcontrib>Lopes, Luis</creatorcontrib><creatorcontrib>Saadi, Malika</creatorcontrib><creatorcontrib>Gossios, Thomas</creatorcontrib><creatorcontrib>Procaccio, Vincent</creatorcontrib><creatorcontrib>Spinazzi, Marco</creatorcontrib><creatorcontrib>Tard, Céline</creatorcontrib><creatorcontrib>De Groote, Pascal</creatorcontrib><creatorcontrib>Dhaenens, Claire-Marie</creatorcontrib><creatorcontrib>Douillard, Claire</creatorcontrib><creatorcontrib>Echaniz-Laguna, Andoni</creatorcontrib><creatorcontrib>Quinlivan, Ros</creatorcontrib><creatorcontrib>Hanna, Michael G</creatorcontrib><creatorcontrib>Yilmaz, Ali</creatorcontrib><creatorcontrib>Vissing, John</creatorcontrib><creatorcontrib>Laforêt, Pascal</creatorcontrib><creatorcontrib>Elliott, Perry</creatorcontrib><creatorcontrib>Wahbi, Karim</creatorcontrib><title>Cardiac Outcomes in Adults With Mitochondrial Diseases</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>Patients with mitochondrial diseases are at risk of heart failure (HF) and arrhythmic major adverse cardiac events (MACE).
We developed prediction models to estimate the risk of HF and arrhythmic MACE in this population.
We determined the incidence and searched for predictors of HF and arrhythmic MACE using Cox regression in 600 adult patients from a multicenter registry with genetically confirmed mitochondrial diseases.
Over a median follow-up time of 6.67 years, 29 patients (4.9%) reached the HF endpoint, including 19 hospitalizations for nonterminal HF, 2 cardiac transplantations, and 8 deaths from HF. Thirty others (5.1%) reached the arrhythmic MACE, including 21 with third-degree or type II second-degree atrioventricular blocks, 4 with sinus node dysfunction, and 5 sudden cardiac deaths. Predictors of HF were the m.3243A>G variant (HR: 4.3; 95% CI: 1.8-10.1), conduction defects (HR: 3.0; 95% CI: 1.3-6.9), left ventricular (LV) hypertrophy (HR: 2.6; 95% CI: 1.1-5.8), LV ejection fraction <50% (HR: 10.2; 95% CI: 4.6-22.3), and premature ventricular beats (HR: 4.1; 95% CI: 1.7-9.9). Independent predictors for arrhythmia were single, large-scale mtDNA deletions (HR: 4.3; 95% CI: 1.7-10.4), conduction defects (HR: 6.8; 95% CI: 3.0-15.4), and LV ejection fraction <50% (HR: 2.7; 95% CI: 1.1-7.1). C-indexes of the Cox regression models were 0.91 (95% CI: 0.88-0.95) and 0.80 (95% CI: 0.70-0.90) for the HF and arrhythmic MACE, respectively.
We developed the first prediction models for HF and arrhythmic MACE in patients with mitochondrial diseases using genetic variant type and simple cardiac assessments.</description><subject>Adult</subject><subject>DNA, Mitochondrial - genetics</subject><subject>Heart</subject><subject>Heart Failure - epidemiology</subject><subject>Humans</subject><subject>Hypertrophy, Left Ventricular</subject><subject>Life Sciences</subject><subject>Mitochondrial Diseases - complications</subject><subject>Mitochondrial Diseases - epidemiology</subject><subject>Mitochondrial Diseases - genetics</subject><subject>Prognosis</subject><subject>Risk Factors</subject><subject>Stroke Volume</subject><subject>Ventricular Function, Left</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1OwzAQhS0EoqVwARYoS1gkjO3acZZV-SlSUTcglpZjO6qjpClxgsRtOAsnw1FKVzMafe-N3kPoGkOCAfP7MimV1gkBQhIQSYr5CZpixkRMWZaeoimklMUYsnSCLrwvAYALnJ2jCeVBxCiZonSpWuOUjjZ9p5va-sjtooXpq85HH67b_v68uq7R22ZnWqeq6MF5q7z1l-isUJW3V4c5Q-9Pj2_LVbzePL8sF-tYU4G7WHNIC5yZPKdW51bZgmWF1rkAaoSdMwVzbExYYS44cMJ5zo1hIYPABbaaztDd6LtVldy3rlbtt2yUk6vFWg43oIKG5NkXDuztyO7b5rO3vpO189pWldrZpveSpIRixgWhASUjqtvG-9YWR28McihXlnIoVw7lShAyvAiim4N_n9fWHCX_bdI_LXB2Bg</recordid><startdate>20221011</startdate><enddate>20221011</enddate><creator>Savvatis, Konstantinos</creator><creator>Vissing, Christoffer Rasmus</creator><creator>Klouvi, Lori</creator><creator>Florian, Anca</creator><creator>Rahman, Mehjabin</creator><creator>Béhin, Anthony</creator><creator>Fayssoil, Abdallah</creator><creator>Masingue, Marion</creator><creator>Stojkovic, Tanya</creator><creator>Bécane, Henri Marc</creator><creator>Berber, Nawal</creator><creator>Mochel, Fanny</creator><creator>Duboc, Denis</creator><creator>Fontaine, Bertrand</creator><creator>Krett, Bjørg</creator><creator>Stalens, Caroline</creator><creator>Lejeune, Julie</creator><creator>Pitceathly, Robert D S</creator><creator>Lopes, Luis</creator><creator>Saadi, Malika</creator><creator>Gossios, Thomas</creator><creator>Procaccio, Vincent</creator><creator>Spinazzi, Marco</creator><creator>Tard, Céline</creator><creator>De Groote, Pascal</creator><creator>Dhaenens, Claire-Marie</creator><creator>Douillard, Claire</creator><creator>Echaniz-Laguna, Andoni</creator><creator>Quinlivan, Ros</creator><creator>Hanna, Michael G</creator><creator>Yilmaz, Ali</creator><creator>Vissing, John</creator><creator>Laforêt, Pascal</creator><creator>Elliott, Perry</creator><creator>Wahbi, Karim</creator><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0003-1966-1880</orcidid><orcidid>https://orcid.org/0000-0003-3383-3984</orcidid><orcidid>https://orcid.org/0000-0002-6123-4551</orcidid><orcidid>https://orcid.org/0000-0001-6260-9813</orcidid><orcidid>https://orcid.org/0000-0003-3844-5438</orcidid><orcidid>https://orcid.org/0000-0002-6408-4667</orcidid><orcidid>https://orcid.org/0000-0002-0834-206X</orcidid><orcidid>https://orcid.org/0000-0002-4054-2838</orcidid><orcidid>https://orcid.org/0000-0003-0048-9558</orcidid></search><sort><creationdate>20221011</creationdate><title>Cardiac Outcomes in Adults With Mitochondrial Diseases</title><author>Savvatis, Konstantinos ; Vissing, Christoffer Rasmus ; Klouvi, Lori ; Florian, Anca ; Rahman, Mehjabin ; Béhin, Anthony ; Fayssoil, Abdallah ; Masingue, Marion ; Stojkovic, Tanya ; Bécane, Henri Marc ; Berber, Nawal ; Mochel, Fanny ; Duboc, Denis ; Fontaine, Bertrand ; Krett, Bjørg ; Stalens, Caroline ; Lejeune, Julie ; Pitceathly, Robert D S ; Lopes, Luis ; Saadi, Malika ; Gossios, Thomas ; Procaccio, Vincent ; Spinazzi, Marco ; Tard, Céline ; De Groote, Pascal ; Dhaenens, Claire-Marie ; Douillard, Claire ; Echaniz-Laguna, Andoni ; Quinlivan, Ros ; Hanna, Michael G ; Yilmaz, Ali ; Vissing, John ; Laforêt, Pascal ; Elliott, Perry ; Wahbi, Karim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-c607f19dbb3ecbeaef59fccb803d8e45a041ddd8e048606266b6dd555881f1ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>DNA, Mitochondrial - genetics</topic><topic>Heart</topic><topic>Heart Failure - epidemiology</topic><topic>Humans</topic><topic>Hypertrophy, Left Ventricular</topic><topic>Life Sciences</topic><topic>Mitochondrial Diseases - complications</topic><topic>Mitochondrial Diseases - epidemiology</topic><topic>Mitochondrial Diseases - genetics</topic><topic>Prognosis</topic><topic>Risk Factors</topic><topic>Stroke Volume</topic><topic>Ventricular Function, Left</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Savvatis, Konstantinos</creatorcontrib><creatorcontrib>Vissing, Christoffer Rasmus</creatorcontrib><creatorcontrib>Klouvi, Lori</creatorcontrib><creatorcontrib>Florian, Anca</creatorcontrib><creatorcontrib>Rahman, Mehjabin</creatorcontrib><creatorcontrib>Béhin, Anthony</creatorcontrib><creatorcontrib>Fayssoil, Abdallah</creatorcontrib><creatorcontrib>Masingue, Marion</creatorcontrib><creatorcontrib>Stojkovic, Tanya</creatorcontrib><creatorcontrib>Bécane, Henri Marc</creatorcontrib><creatorcontrib>Berber, Nawal</creatorcontrib><creatorcontrib>Mochel, Fanny</creatorcontrib><creatorcontrib>Duboc, Denis</creatorcontrib><creatorcontrib>Fontaine, Bertrand</creatorcontrib><creatorcontrib>Krett, Bjørg</creatorcontrib><creatorcontrib>Stalens, Caroline</creatorcontrib><creatorcontrib>Lejeune, Julie</creatorcontrib><creatorcontrib>Pitceathly, Robert D S</creatorcontrib><creatorcontrib>Lopes, Luis</creatorcontrib><creatorcontrib>Saadi, Malika</creatorcontrib><creatorcontrib>Gossios, Thomas</creatorcontrib><creatorcontrib>Procaccio, Vincent</creatorcontrib><creatorcontrib>Spinazzi, Marco</creatorcontrib><creatorcontrib>Tard, Céline</creatorcontrib><creatorcontrib>De Groote, Pascal</creatorcontrib><creatorcontrib>Dhaenens, Claire-Marie</creatorcontrib><creatorcontrib>Douillard, Claire</creatorcontrib><creatorcontrib>Echaniz-Laguna, Andoni</creatorcontrib><creatorcontrib>Quinlivan, Ros</creatorcontrib><creatorcontrib>Hanna, Michael G</creatorcontrib><creatorcontrib>Yilmaz, Ali</creatorcontrib><creatorcontrib>Vissing, John</creatorcontrib><creatorcontrib>Laforêt, Pascal</creatorcontrib><creatorcontrib>Elliott, Perry</creatorcontrib><creatorcontrib>Wahbi, Karim</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Savvatis, Konstantinos</au><au>Vissing, Christoffer Rasmus</au><au>Klouvi, Lori</au><au>Florian, Anca</au><au>Rahman, Mehjabin</au><au>Béhin, Anthony</au><au>Fayssoil, Abdallah</au><au>Masingue, Marion</au><au>Stojkovic, Tanya</au><au>Bécane, Henri Marc</au><au>Berber, Nawal</au><au>Mochel, Fanny</au><au>Duboc, Denis</au><au>Fontaine, Bertrand</au><au>Krett, Bjørg</au><au>Stalens, Caroline</au><au>Lejeune, Julie</au><au>Pitceathly, Robert D S</au><au>Lopes, Luis</au><au>Saadi, Malika</au><au>Gossios, Thomas</au><au>Procaccio, Vincent</au><au>Spinazzi, Marco</au><au>Tard, Céline</au><au>De Groote, Pascal</au><au>Dhaenens, Claire-Marie</au><au>Douillard, Claire</au><au>Echaniz-Laguna, Andoni</au><au>Quinlivan, Ros</au><au>Hanna, Michael G</au><au>Yilmaz, Ali</au><au>Vissing, John</au><au>Laforêt, Pascal</au><au>Elliott, Perry</au><au>Wahbi, Karim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiac Outcomes in Adults With Mitochondrial Diseases</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2022-10-11</date><risdate>2022</risdate><volume>80</volume><issue>15</issue><spage>1421</spage><epage>1430</epage><pages>1421-1430</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><abstract>Patients with mitochondrial diseases are at risk of heart failure (HF) and arrhythmic major adverse cardiac events (MACE).
We developed prediction models to estimate the risk of HF and arrhythmic MACE in this population.
We determined the incidence and searched for predictors of HF and arrhythmic MACE using Cox regression in 600 adult patients from a multicenter registry with genetically confirmed mitochondrial diseases.
Over a median follow-up time of 6.67 years, 29 patients (4.9%) reached the HF endpoint, including 19 hospitalizations for nonterminal HF, 2 cardiac transplantations, and 8 deaths from HF. Thirty others (5.1%) reached the arrhythmic MACE, including 21 with third-degree or type II second-degree atrioventricular blocks, 4 with sinus node dysfunction, and 5 sudden cardiac deaths. Predictors of HF were the m.3243A>G variant (HR: 4.3; 95% CI: 1.8-10.1), conduction defects (HR: 3.0; 95% CI: 1.3-6.9), left ventricular (LV) hypertrophy (HR: 2.6; 95% CI: 1.1-5.8), LV ejection fraction <50% (HR: 10.2; 95% CI: 4.6-22.3), and premature ventricular beats (HR: 4.1; 95% CI: 1.7-9.9). Independent predictors for arrhythmia were single, large-scale mtDNA deletions (HR: 4.3; 95% CI: 1.7-10.4), conduction defects (HR: 6.8; 95% CI: 3.0-15.4), and LV ejection fraction <50% (HR: 2.7; 95% CI: 1.1-7.1). C-indexes of the Cox regression models were 0.91 (95% CI: 0.88-0.95) and 0.80 (95% CI: 0.70-0.90) for the HF and arrhythmic MACE, respectively.
We developed the first prediction models for HF and arrhythmic MACE in patients with mitochondrial diseases using genetic variant type and simple cardiac assessments.</abstract><cop>United States</cop><pub>Elsevier</pub><pmid>36202532</pmid><doi>10.1016/j.jacc.2022.08.716</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-1966-1880</orcidid><orcidid>https://orcid.org/0000-0003-3383-3984</orcidid><orcidid>https://orcid.org/0000-0002-6123-4551</orcidid><orcidid>https://orcid.org/0000-0001-6260-9813</orcidid><orcidid>https://orcid.org/0000-0003-3844-5438</orcidid><orcidid>https://orcid.org/0000-0002-6408-4667</orcidid><orcidid>https://orcid.org/0000-0002-0834-206X</orcidid><orcidid>https://orcid.org/0000-0002-4054-2838</orcidid><orcidid>https://orcid.org/0000-0003-0048-9558</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0735-1097 |
| ispartof | Journal of the American College of Cardiology, 2022-10, Vol.80 (15), p.1421-1430 |
| issn | 0735-1097 1558-3597 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_03837169v1 |
| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult DNA, Mitochondrial - genetics Heart Heart Failure - epidemiology Humans Hypertrophy, Left Ventricular Life Sciences Mitochondrial Diseases - complications Mitochondrial Diseases - epidemiology Mitochondrial Diseases - genetics Prognosis Risk Factors Stroke Volume Ventricular Function, Left |
| title | Cardiac Outcomes in Adults With Mitochondrial Diseases |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-18T22%3A48%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cardiac%20Outcomes%20in%20Adults%20With%C2%A0Mitochondrial%20Diseases&rft.jtitle=Journal%20of%20the%20American%20College%20of%20Cardiology&rft.au=Savvatis,%20Konstantinos&rft.date=2022-10-11&rft.volume=80&rft.issue=15&rft.spage=1421&rft.epage=1430&rft.pages=1421-1430&rft.issn=0735-1097&rft.eissn=1558-3597&rft_id=info:doi/10.1016/j.jacc.2022.08.716&rft_dat=%3Cproquest_hal_p%3E2723156823%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2723156823&rft_id=info:pmid/36202532&rfr_iscdi=true |