NOD2-Deficient Mice Have Impaired Resistance to Mycobacterium tuberculosis Infection through Defective Innate and Adaptive Immunity

NOD2/CARD15 mediates innate immune responses to mycobacterial infection. However, its role in the regulation of adaptive immunity has remained unknown. In this study, we examined host defense, T cell responses, and tissue pathology in two models of pulmonary mycobacterial infection, using wild-type...

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Veröffentlicht in:	The Journal of immunology (1950) 2008-11, Vol.181 (10), p.7157-7165
Hauptverfasser:	Divangahi, Maziar, Mostowy, Serge, Coulombe, Francois, Kozak, Robert, Guillot, Loic, Veyrier, Frederic, Kobayashi, Koichi S, Flavell, Richard A, Gros, Philippe, Behr, Marcel A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Chemotaxis, Leukocyte Cytokines - biosynthesis Flow Cytometry Immunity, Innate Life Sciences Lung - immunology Lung - microbiology Lung - pathology Lymphocyte Activation - immunology Macrophages, Alveolar - immunology Macrophages, Alveolar - metabolism Macrophages, Alveolar - microbiology Mice Microscopy, Confocal Mycobacterium tuberculosis Nod2 Signaling Adaptor Protein - deficiency Nod2 Signaling Adaptor Protein - immunology Tuberculosis, Pulmonary - immunology
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