Discovery and Characterization of Two Isoforms of Moronecidin, a Novel Antimicrobial Peptide from Hybrid Striped Bass

We isolated a novel 22-residue, C-terminally amidated antimicrobial peptide, moronecidin, from the skin and gill of hybrid striped bass. Two isoforms, differing by only one amino acid, are derived from each parental species, white bass ( Morone chrysops ) and striped bass ( Morone saxatilis ). Molec...

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Veröffentlicht in:	The Journal of biological chemistry 2002-02, Vol.277 (7), p.5030-5039
Hauptverfasser:	Lauth, Xavier, Shike, Hiroko, Burns, Jane C, Westerman, Mark E, Ostland, Vaughn E, Carlberg, James M, Van Olst, Jon C, Nizet, Victor, Taylor, Steven W, Shimizu, Chisato, Bulet, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Amino Acid Sequence Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antimicrobial Cationic Peptides Base Sequence Bass Circular Dichroism DNA, Complementary - metabolism Exons Fish Proteins Freshwater Hemolysis Introns Kinetics Life Sciences Models, Genetic Molecular Sequence Data Morone chrysops Morone saxatilis moronecidin Open Reading Frames Peptide Biosynthesis Peptides - chemistry Protein Conformation Protein Isoforms Protein Structure, Secondary Protein Structure, Tertiary Proteins - chemistry Proteins - pharmacology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Time Factors Tissue Distribution Transcription, Genetic
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