Respiratory effects of buprenorphine/naloxone alone and in combination with diazepam in naive and tolerant rats

•Like buprenorphine alone, buprenorphine/naloxone does not depress ventilation in rats.•IV buprenorphine/naloxone injection induces withdrawal symptoms in tolerant rats.•Naloxone does not prevent the deleterious respiratory effects of buprenorphine/diazepam. Respiratory depression has been attribute...

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Veröffentlicht in:	Toxicology letters 2014-07, Vol.228 (2), p.75-84
Hauptverfasser:	Cohier, Camille, Chevillard, Lucie, Risède, Patricia, Roussel, Olivier, Mégarbane, Bruno
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - toxicity Analysis of Variance Animals Buprenorphine Buprenorphine - toxicity Diazepam Diazepam - toxicity Drug Interactions Drug Tolerance Hypnotics and Sedatives - toxicity Life Sciences Male Naloxone Naloxone - toxicity Narcotic Antagonists - toxicity Plethysmography, Whole Body Rats Rats, Sprague-Dawley Respiratory depression Respiratory Insufficiency - chemically induced Toxicology Whole-body plethysmography
Online-Zugang:	Volltext
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