The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic protein

Abstract Facioscapulohumeral muscular dystrophy (FSHD) patients carry contractions of the D4Z4-tandem repeat array on chromosome 4q35. Decrease in D4Z4 copy number is thought to alter a chromatin structure and activate expression of neighboring genes. D4Z4 contains a putative double-homeobox gene ca...

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Veröffentlicht in:	Neuromuscular disorders : NMD 2007-08, Vol.17 (8), p.611-623
Hauptverfasser:	Kowaljow, Valeria, Marcowycz, Aline, Ansseau, Eugénie, Conde, Cecilia B, Sauvage, Sébastien, Mattéotti, Christel, Arias, Cristina, Corona, E. Daniel, Nuñez, Nicolás G, Leo, Oberdan, Wattiez, Ruddy, Figlewicz, Denise, Laoudj-Chenivesse, Dalila, Belayew, Alexandra, Coppée, Frédérique, Rosa, Alberto L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Apoptosis Apoptosis - physiology Cell Line, Tumor DUX4 FSHD Gene Expression - physiology Homeobox Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Life Sciences Membrane Proteins - metabolism Molecular Sequence Data Muscle Muscle Cells - cytology Muscle Cells - physiology Muscular Dystrophy, Facioscapulohumeral - genetics Muscular Dystrophy, Facioscapulohumeral - pathology Muscular Dystrophy, Facioscapulohumeral - physiopathology Neurology Nuclear Envelope - metabolism Nuclear Proteins - metabolism Quadriceps Muscle - cytology Rhabdomyosarcoma RNA, Messenger - metabolism Transcription, Genetic - physiology
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