TWIK1, a unique background channel with variable ion selectivity

TWIK1 belongs to the family of background K(+) channels with two pore domains. In native and transfected cells, TWIK1 is detected mainly in recycling endosomes. In principal cells in the kidney, TWIK1 gene inactivation leads to the loss of a nonselective cationic conductance, an unexpected effect th...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-04, Vol.109 (14), p.5499-5504
Hauptverfasser:	Chatelain, Franck Claude, Bichet, D., Douguet, D., Feliciangeli, S., Bendahhou, S., Reichold, M., Warth, R., Barhanin, J., Lesage, F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry, Molecular Biology Biophysics Cell Behavior Cellular Biology Genomics Immunology Life Sciences Medication Molecular biology Neurobiology Neurons and Cognition Pharmaceutical sciences Pharmacology Subcellular Processes
Online-Zugang:	Volltext
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