CCR7 and IRF4-dependent dendritic cells regulate lymphatic collecting vessel permeability

Lymphatic collecting vessels direct lymph into and from lymph nodes (LNs) and can become hyperpermeable as the result of a previous infection. Enhanced permeability has been implicated in compromised immunity due to reduced flow of lymph and immune cells to LNs, which are the primary site of antigen...

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Veröffentlicht in:	The Journal of clinical investigation 2016-04, Vol.126 (4), p.1581-1591
Hauptverfasser:	Ivanov, Stoyan, Scallan, Joshua, Kim, Ki-Wook, Werth, Kathrin, Johnson, Michael, Saunders, Brian, Wang, Peter, Kuan, Emma, Straub, Adam, Ouhachi, Melissa, Weinstein, Erica, Williams, Jesse, Briseño, Carlos, Colonna, Marco, Isakson, Brant, Gautier, Emmanuel, Förster, Reinhold, Davis, Michael, Zinselmeyer, Bernd, Randolph, Gwendalyn
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Capillary Permeability Dendritic Cells Fibrosis Interferon Regulatory Factors Life Sciences Lymphatic Vessels Mice Mice, Knockout Receptors, CCR7
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