Chronic Alcohol Consumption Exacerbates the Severity of Psoriasiform Dermatitis in Mice

Background A relationship between alcohol consumption and psoriasis has been reported, but it is unclear whether alcohol consumption aggravates psoriasis. Here, we studied the effect of chronic ethanol (EtOH) consumption in the murine model of Aldara‐induced psoriasiform dermatitis. Methods C57BL/6...

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Veröffentlicht in:	Alcoholism, clinical and experimental research clinical and experimental research, 2020-09, Vol.44 (9), p.1728-1733
Hauptverfasser:	Vasseur, Philippe, Pohin, Mathilde, Gisclard, Coralie, Jégou, Jean‐François, Morel, Franck, Silvain, Christine, Lecron, Jean‐Claude
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunology Alcohol Alcohol Drinking Alcohol use Animal models Animals Antiviral drugs Biochemistry Biochemistry, Molecular Biology CCL20 protein Central Nervous System Depressants - pharmacology Chemokine CCL20 - drug effects Chemokine CCL20 - metabolism Chemokines Dermatitis Dermatology Drinking behavior Drinking water Ethanol Ethanol - pharmacology Gene Expression Profiling Helper cells Human health and pathology IL‐17A Imiquimod Imiquimod - toxicity Immunology Inflammation Innate immunity Interferon Inducers - toxicity Interleukin-17 - genetics Interleukin-22 Interleukin-23 - genetics Interleukins - genetics Keratinocytes Keratinocytes - drug effects Keratinocytes - metabolism Life Sciences Lymphocytes T Mice Psoriasis Psoriasis - genetics Psoriasis - pathology Rodents Skin Skin - drug effects Skin - metabolism Skin - pathology Th17 Cells - drug effects Th17 Cells - metabolism
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