Broader expression of the mouse platelet factor 4‐cre transgene beyond the megakaryocyte lineage

Summary Background Transgenic mice expressing cre recombinase under the control of the platelet factor 4 (Pf4) promoter, in the context of a 100‐kb bacterial artificial chromosome, have become a valuable tool with which to study genetic modifications in the platelet lineage. However, the specificity...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2015-01, Vol.13 (1), p.115-125
Hauptverfasser:	Pertuy, F., Aguilar, A., Strassel, C., Eckly, A., Freund, J.‐N., Duluc, I., Gachet, C., Lanza, F., Léon, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal biology Animals blood platelets Blood Platelets - metabolism Cell Lineage Cells, Cultured Chromosomes, Artificial, Bacterial Colon - cytology Colon - metabolism cre recombinase Epithelial Cells - cytology Epithelial Cells - metabolism Female Gene Expression Regulation, Developmental genetic engineering Genotype Integrases - genetics Leukocytes - metabolism Life Sciences Male megakaryocyte Megakaryocytes - metabolism Mice, Inbred C57BL Mice, Nude Mice, Transgenic Phenotype Platelet Factor 4 - genetics Platelet Factor 4 - metabolism platelet factor 4 Recombination, Genetic Signal Transduction Thrombopoiesis
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