VULNERABILITY OF PROGEROID SMOOTH MUSCLE CELLS TO ARTERIAL SHEAR STRESS IS MEDIATED BY MMP13

Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature aging disease in children that leads to early death. Smooth muscle cells (SMCs) are the most affected cells in HGPS individuals, although the reason for such vulnerability remains poorly understood. In this work, we develop a microfluidic ch...

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Veröffentlicht in:	Nature communications 2022, Vol.28 (1)
Hauptverfasser:	Pitrez, Patricia, Estronca, Luis, Monteiro, Luis, Colell, Guillem, Vazão, Helena, Santinha, Deolinda, Harhouri, Karim, Thornton, Daniel, Navarro, Claire L., Egesipe, Anne-Laure, Cavalho, Tania, dos Santos, Rodrigo L, Levy, Nicolas, Smith, James, Magalhaes, Joao-Pedro, Ori, Alessandro, Bernardo, Andreia, de Sandre-Giovannoli, Annachiara, Nissan, Xavier, Rosell, Anna, Ferreira, Lino
Format:	Artikel
Sprache:	eng
Schlagworte:	Genetics Life Sciences
Online-Zugang:	Volltext
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