Cortical amyloid accumulation is associated with alterations of structural integrity in older people with subjective memory complaints
Abstract We determined the effect of cortical amyloid load using18 F-florbetapir PET on cognitive performance and grey matter structural integrity derived from MRI in 318 cognitively normally performing older people with subjective memory impairment from the INSIGHT-preAD cohort using multivariate p...
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| Veröffentlicht in: | Neurobiology of aging 2017-09, Vol.57, p.143-152 |
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| creator | Teipel, Stefan J Cavedo, Enrica Weschke, Sarah Grothe, Michel J Rojkova, Katrine Fontaine, Gaëlle Dauphinot, Luce Gonzales-Escamilla, Gabriel Potier, Marie-Claude Bertin, Hugo Habert, Marie-Odile Dubois, Bruno Hampel, Harald |
| description | Abstract We determined the effect of cortical amyloid load using18 F-florbetapir PET on cognitive performance and grey matter structural integrity derived from MRI in 318 cognitively normally performing older people with subjective memory impairment from the INSIGHT-preAD cohort using multivariate partial least square regression. Amyloid uptake was associated with reduced grey matter structural integrity in hippocampus, entorhinal and cingulate cortex, middle temporal gyrus, prefrontal cortex, and lentiform nucleus (p < 0.01, permutation test). Higher amyloid load was associated with poorer global cognitive performance, delayed recall and attention (p < 0.05), independently of its effects on grey matter connectivity. These findings agree with the assumption of a two stage effect of amyloid on cognition, (i) an early direct effect in preclinical stages of Alzheimer’s disease (AD) and (ii) a delayed effect mediated by down-stream effects of amyloid accumulation, such as grey matter connectivity decline. |
| doi_str_mv | 10.1016/j.neurobiolaging.2017.05.016 |
| format | Article |
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Amyloid uptake was associated with reduced grey matter structural integrity in hippocampus, entorhinal and cingulate cortex, middle temporal gyrus, prefrontal cortex, and lentiform nucleus (p < 0.01, permutation test). Higher amyloid load was associated with poorer global cognitive performance, delayed recall and attention (p < 0.05), independently of its effects on grey matter connectivity. These findings agree with the assumption of a two stage effect of amyloid on cognition, (i) an early direct effect in preclinical stages of Alzheimer’s disease (AD) and (ii) a delayed effect mediated by down-stream effects of amyloid accumulation, such as grey matter connectivity decline.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/j.neurobiolaging.2017.05.016</identifier><identifier>PMID: 28646687</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Aging ; Aging - metabolism ; Aging - pathology ; Aging - psychology ; Amyloid beta-Peptides ; Amyloid beta-Peptides - metabolism ; Amyloid load ; Attention ; Brain ; Brain - diagnostic imaging ; Brain - metabolism ; Brain - pathology ; Cerebral reserve ; Cognition ; Cohort Studies ; Female ; Humans ; Internal Medicine ; Life Sciences ; Magnetic Resonance Imaging ; Male ; Memory Disorders ; Memory Disorders - diagnostic imaging ; Memory Disorders - metabolism ; Memory Disorders - pathology ; Memory Disorders - psychology ; Mental Recall ; MRI ; Neuroimaging ; Neurology ; PET ; Positron-Emission Tomography ; Structural connectivity ; Subjective memory impairment</subject><ispartof>Neurobiology of aging, 2017-09, Vol.57, p.143-152</ispartof><rights>2017 Elsevier Inc.</rights><rights>Copyright © 2017 Elsevier Inc. All rights reserved.</rights><rights>Attribution</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-156cab9d896ff683657445acbd2027d5bca1acabf53708f46b17216a99e51bb03</citedby><cites>FETCH-LOGICAL-c475t-156cab9d896ff683657445acbd2027d5bca1acabf53708f46b17216a99e51bb03</cites><orcidid>0000-0003-2600-9022 ; 0000-0002-9836-654X ; 0000-0003-0894-8982 ; 0000-0003-2462-7150</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0197458017301835$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28646687$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03769687$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Teipel, Stefan J</creatorcontrib><creatorcontrib>Cavedo, Enrica</creatorcontrib><creatorcontrib>Weschke, Sarah</creatorcontrib><creatorcontrib>Grothe, Michel J</creatorcontrib><creatorcontrib>Rojkova, Katrine</creatorcontrib><creatorcontrib>Fontaine, Gaëlle</creatorcontrib><creatorcontrib>Dauphinot, Luce</creatorcontrib><creatorcontrib>Gonzales-Escamilla, Gabriel</creatorcontrib><creatorcontrib>Potier, Marie-Claude</creatorcontrib><creatorcontrib>Bertin, Hugo</creatorcontrib><creatorcontrib>Habert, Marie-Odile</creatorcontrib><creatorcontrib>Dubois, Bruno</creatorcontrib><creatorcontrib>Hampel, Harald</creatorcontrib><creatorcontrib>INSIGHT-preAD study group</creatorcontrib><title>Cortical amyloid accumulation is associated with alterations of structural integrity in older people with subjective memory complaints</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>Abstract We determined the effect of cortical amyloid load using18 F-florbetapir PET on cognitive performance and grey matter structural integrity derived from MRI in 318 cognitively normally performing older people with subjective memory impairment from the INSIGHT-preAD cohort using multivariate partial least square regression. Amyloid uptake was associated with reduced grey matter structural integrity in hippocampus, entorhinal and cingulate cortex, middle temporal gyrus, prefrontal cortex, and lentiform nucleus (p < 0.01, permutation test). Higher amyloid load was associated with poorer global cognitive performance, delayed recall and attention (p < 0.05), independently of its effects on grey matter connectivity. 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Cavedo, Enrica ; Weschke, Sarah ; Grothe, Michel J ; Rojkova, Katrine ; Fontaine, Gaëlle ; Dauphinot, Luce ; Gonzales-Escamilla, Gabriel ; Potier, Marie-Claude ; Bertin, Hugo ; Habert, Marie-Odile ; Dubois, Bruno ; Hampel, Harald</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-156cab9d896ff683657445acbd2027d5bca1acabf53708f46b17216a99e51bb03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Aging - metabolism</topic><topic>Aging - pathology</topic><topic>Aging - psychology</topic><topic>Amyloid beta-Peptides</topic><topic>Amyloid beta-Peptides - metabolism</topic><topic>Amyloid load</topic><topic>Attention</topic><topic>Brain</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - metabolism</topic><topic>Brain - pathology</topic><topic>Cerebral reserve</topic><topic>Cognition</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Life Sciences</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Memory Disorders</topic><topic>Memory Disorders - diagnostic imaging</topic><topic>Memory Disorders - metabolism</topic><topic>Memory Disorders - pathology</topic><topic>Memory Disorders - psychology</topic><topic>Mental Recall</topic><topic>MRI</topic><topic>Neuroimaging</topic><topic>Neurology</topic><topic>PET</topic><topic>Positron-Emission Tomography</topic><topic>Structural connectivity</topic><topic>Subjective memory impairment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Teipel, Stefan J</creatorcontrib><creatorcontrib>Cavedo, Enrica</creatorcontrib><creatorcontrib>Weschke, Sarah</creatorcontrib><creatorcontrib>Grothe, Michel J</creatorcontrib><creatorcontrib>Rojkova, Katrine</creatorcontrib><creatorcontrib>Fontaine, Gaëlle</creatorcontrib><creatorcontrib>Dauphinot, Luce</creatorcontrib><creatorcontrib>Gonzales-Escamilla, Gabriel</creatorcontrib><creatorcontrib>Potier, Marie-Claude</creatorcontrib><creatorcontrib>Bertin, Hugo</creatorcontrib><creatorcontrib>Habert, Marie-Odile</creatorcontrib><creatorcontrib>Dubois, Bruno</creatorcontrib><creatorcontrib>Hampel, Harald</creatorcontrib><creatorcontrib>INSIGHT-preAD study group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Teipel, Stefan J</au><au>Cavedo, Enrica</au><au>Weschke, Sarah</au><au>Grothe, Michel J</au><au>Rojkova, Katrine</au><au>Fontaine, Gaëlle</au><au>Dauphinot, Luce</au><au>Gonzales-Escamilla, Gabriel</au><au>Potier, Marie-Claude</au><au>Bertin, Hugo</au><au>Habert, Marie-Odile</au><au>Dubois, Bruno</au><au>Hampel, Harald</au><aucorp>INSIGHT-preAD study group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cortical amyloid accumulation is associated with alterations of structural integrity in older people with subjective memory complaints</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>57</volume><spage>143</spage><epage>152</epage><pages>143-152</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><abstract>Abstract We determined the effect of cortical amyloid load using18 F-florbetapir PET on cognitive performance and grey matter structural integrity derived from MRI in 318 cognitively normally performing older people with subjective memory impairment from the INSIGHT-preAD cohort using multivariate partial least square regression. Amyloid uptake was associated with reduced grey matter structural integrity in hippocampus, entorhinal and cingulate cortex, middle temporal gyrus, prefrontal cortex, and lentiform nucleus (p < 0.01, permutation test). Higher amyloid load was associated with poorer global cognitive performance, delayed recall and attention (p < 0.05), independently of its effects on grey matter connectivity. 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| ispartof | Neurobiology of aging, 2017-09, Vol.57, p.143-152 |
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| subjects | Aged Aged, 80 and over Aging Aging - metabolism Aging - pathology Aging - psychology Amyloid beta-Peptides Amyloid beta-Peptides - metabolism Amyloid load Attention Brain Brain - diagnostic imaging Brain - metabolism Brain - pathology Cerebral reserve Cognition Cohort Studies Female Humans Internal Medicine Life Sciences Magnetic Resonance Imaging Male Memory Disorders Memory Disorders - diagnostic imaging Memory Disorders - metabolism Memory Disorders - pathology Memory Disorders - psychology Mental Recall MRI Neuroimaging Neurology PET Positron-Emission Tomography Structural connectivity Subjective memory impairment |
| title | Cortical amyloid accumulation is associated with alterations of structural integrity in older people with subjective memory complaints |
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