Occludin stalls HCV particle dynamics apart from hepatocyte tight junctions, promoting virion internalization

Background and Aims Numerous HCV entry factors have been identified, and yet information regarding their spatiotemporal dynamics is still limited. Specifically, one of the main entry factors of HCV is occludin (OCLN), a protein clustered at tight junctions (TJs), away from the HCV landing site. Thus...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2022-10, Vol.76 (4), p.1164-1179
Hauptverfasser:	Deffieu, Maika S., Clément, Camille M. H, Dorobantu, Cristina M., Partiot, Emma, Bare, Yonis, Faklaris, Orestis, Rivière, Benjamin, Ayala‐Nunez, Nilda Vanesa, Baumert, Thomas F., Rondé, Philippe, Mély, Yves, Lucansky, Vincent, Gaudin, Raphael
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cell culture Cellular Biology Claudin-1 - genetics CRISPR CRISPR-Associated Protein 9 - metabolism Cytoskeleton Explants Ezrin Green fluorescent protein Hematology Hepacivirus - physiology Hepatitis C - metabolism Hepatocytes - metabolism Hepatology Human health and pathology Humans Infectious diseases Internalization Life Sciences Localization Microbiology and Parasitology Occludin Phosphorylation Proteins Recruitment Tight Junctions Virion Virions Virology Virus Internalization
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