Hematopoietic stem cell transplantation for acute lymphoblastic leukemia: why do adolescents and young adults outcomes differ from those of children? A retrospective study on behalf of the Francophone Society of Stem Cell Transplantation and Cellular Therapy (SFGM-TC)
Purpose In the acute lymphoblastic leukemia (ALL) landscape, adolescents and young adults (AYA) often present high-risk diseases and increased chemotherapy-related toxicity. Studies analyzing the outcomes of AYA after hematopoietic stem cell transplantation (HSCT) are scarce. Our study aimed to comp...
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| Veröffentlicht in: | Journal of cancer research and clinical oncology 2023-04, Vol.149 (4), p.1473-1483 |
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| creator | Grain, Audrey Rialland-Battisti, Fanny Chevallier, Patrice Blin, Nicolas Dalle, Jean-Hugues Michel, Gérard Dhédin, Nathalie Peffault de Latour, Regis Pochon, Cécile Yakoub-Agha, Ibrahim Bertrand, Yves Sirvent, Anne Jubert, Charlotte Forcade, Edouard Berceanu, Ana Gandemer, Virginie Schneider, Pascale Bay, Jacques-Olivier Rohrlich, Pierre-Simon Brissot, Eolia Paillard, Catherine Plantaz, Dominique Nguyen Quoc, Stéphanie Gonzales, Fanny Maillard, Natacha Planche, Lucie Baruchel, André |
| description | Purpose
In the acute lymphoblastic leukemia (ALL) landscape, adolescents and young adults (AYA) often present high-risk diseases and increased chemotherapy-related toxicity. Studies analyzing the outcomes of AYA after hematopoietic stem cell transplantation (HSCT) are scarce. Our study aimed to compare the outcomes of children and AYA with ALL after HSCT and to determine the factors influencing potential differences.
Method
891 patients, from the SFGM-TC registry, aged between 1 and 25 years who received HSCT between 2005 and 2012 were included. The outcomes of AYA were compared to the ones of their younger counterparts.
Results
Five-year OS and GRFS were lower in AYA: 53.1% versus 64% and 36% versus 47% (
p
= 0.0012 and
p
= 0.007, respectively). WhileCIR was similar in both groups, 5 year-treatment related mortality was higher in AYA: 19% versus 13% (
p
= 0.04). The lower GRFS in AYA was mainly explained by a higher chronic graft versus host disease (cGvHD) incidence: 32% versus 19% (
p
|
| doi_str_mv | 10.1007/s00432-022-04021-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_03737646v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2787440711</sourcerecordid><originalsourceid>FETCH-LOGICAL-c453t-87cfdd7454e48d9fcfa4cb134da0f79dcb1ac83b31c1eec72d8f6856a58e28743</originalsourceid><addsrcrecordid>eNp9UsFu1DAUDAhEl5Yf4ICexIUeAnacrFMuaLViu0iLOOxyjrz2c5PixKntFOXvsdlSJA4cIsfvzRvP2JNlryl5TwnhHzwhJStyUsSvJAXN6dNsQVOJMlY9yxaEcppXBV2eZS-9vyVxX_HiRXbGqopwStjiycUWexHsaDsMnQQfsAeJxkBwYvCjEUMQobMDaOtAyCkgmLkfW3s0wqcJg9MP7DvxEX62MygLQlmDXuIQPIhBwWyn4SZWJxMLdgrS9uhBdVqjA-1sD6G1HsFqkG1nlMPhE6zAYXDWjyhDd49R16RmiDKO2AqjEzi0CJsoUtqoZkDYWxk9zKm1Ty7WycXhHxdJUGpMRjg4tOjEOMO7_eb6a35YX15kz7UwHl89rOfZ983nw3qb775df1mvdrksKxbymkutFC-rEstaXWmpRSmPlJVKEM2vVPwXsmZHRiVFlLxQtV7W1VJUNRY1L9l5dnnijV6a0XW9cHNjRddsV7sm1QjjjC_L5T2N2Lcn7Ojs3YQ-NLd2ckOU1xQ8kpXxIROqOKFkvDTvUD_SUtKksDSnsDQxLM3vsDRp6M0D9XTsUT2O_ElHBLATwMfWcIPu79n_of0FyIXPdg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2787440711</pqid></control><display><type>article</type><title>Hematopoietic stem cell transplantation for acute lymphoblastic leukemia: why do adolescents and young adults outcomes differ from those of children? A retrospective study on behalf of the Francophone Society of Stem Cell Transplantation and Cellular Therapy (SFGM-TC)</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Grain, Audrey ; Rialland-Battisti, Fanny ; Chevallier, Patrice ; Blin, Nicolas ; Dalle, Jean-Hugues ; Michel, Gérard ; Dhédin, Nathalie ; Peffault de Latour, Regis ; Pochon, Cécile ; Yakoub-Agha, Ibrahim ; Bertrand, Yves ; Sirvent, Anne ; Jubert, Charlotte ; Forcade, Edouard ; Berceanu, Ana ; Gandemer, Virginie ; Schneider, Pascale ; Bay, Jacques-Olivier ; Rohrlich, Pierre-Simon ; Brissot, Eolia ; Paillard, Catherine ; Plantaz, Dominique ; Nguyen Quoc, Stéphanie ; Gonzales, Fanny ; Maillard, Natacha ; Planche, Lucie ; Baruchel, André</creator><creatorcontrib>Grain, Audrey ; Rialland-Battisti, Fanny ; Chevallier, Patrice ; Blin, Nicolas ; Dalle, Jean-Hugues ; Michel, Gérard ; Dhédin, Nathalie ; Peffault de Latour, Regis ; Pochon, Cécile ; Yakoub-Agha, Ibrahim ; Bertrand, Yves ; Sirvent, Anne ; Jubert, Charlotte ; Forcade, Edouard ; Berceanu, Ana ; Gandemer, Virginie ; Schneider, Pascale ; Bay, Jacques-Olivier ; Rohrlich, Pierre-Simon ; Brissot, Eolia ; Paillard, Catherine ; Plantaz, Dominique ; Nguyen Quoc, Stéphanie ; Gonzales, Fanny ; Maillard, Natacha ; Planche, Lucie ; Baruchel, André</creatorcontrib><description>Purpose
In the acute lymphoblastic leukemia (ALL) landscape, adolescents and young adults (AYA) often present high-risk diseases and increased chemotherapy-related toxicity. Studies analyzing the outcomes of AYA after hematopoietic stem cell transplantation (HSCT) are scarce. Our study aimed to compare the outcomes of children and AYA with ALL after HSCT and to determine the factors influencing potential differences.
Method
891 patients, from the SFGM-TC registry, aged between 1 and 25 years who received HSCT between 2005 and 2012 were included. The outcomes of AYA were compared to the ones of their younger counterparts.
Results
Five-year OS and GRFS were lower in AYA: 53.1% versus 64% and 36% versus 47% (
p
= 0.0012 and
p
= 0.007, respectively). WhileCIR was similar in both groups, 5 year-treatment related mortality was higher in AYA: 19% versus 13% (
p
= 0.04). The lower GRFS in AYA was mainly explained by a higher chronic graft versus host disease (cGvHD) incidence: 32% versus 19% (
p
< 0.001). Use of peripheral blood stem cells and use of anti-thymoglobulin appeared to be the main factors impacting cGvHD occurrence in AYA.
Conclusion
AYA have worse outcomes than children after HSCT for ALL because of a greater risk of TRM due to cGvHD. HSCT practices should be questioned in this population.</description><identifier>ISSN: 0171-5216</identifier><identifier>EISSN: 1432-1335</identifier><identifier>DOI: 10.1007/s00432-022-04021-1</identifier><identifier>PMID: 35507103</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acute lymphoblastic leukemia ; Adolescent ; Adolescents ; Adult ; Cancer Research ; Cell therapy ; Chemotherapy ; Child ; Child, Preschool ; Children ; Graft vs Host Disease ; Graft vs Host Disease - epidemiology ; Graft-versus-host reaction ; Hematology ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cell Transplantation - adverse effects ; Hematopoietic stem cells ; Human health and pathology ; Humans ; Infant ; Internal Medicine ; Leukemia ; Life Sciences ; Lymphatic leukemia ; Medicine ; Medicine & Public Health ; Oncology ; Original Article – Clinical Oncology ; Peripheral blood ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy ; Retrospective Studies ; Stem cell transplantation ; Thymoglobulin ; Toxicity ; Young Adult ; Young adults</subject><ispartof>Journal of cancer research and clinical oncology, 2023-04, Vol.149 (4), p.1473-1483</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-87cfdd7454e48d9fcfa4cb134da0f79dcb1ac83b31c1eec72d8f6856a58e28743</citedby><cites>FETCH-LOGICAL-c453t-87cfdd7454e48d9fcfa4cb134da0f79dcb1ac83b31c1eec72d8f6856a58e28743</cites><orcidid>0000-0003-1547-8229 ; 0000-0002-7032-5180 ; 0000-0001-8801-4164 ; 0000-0003-4471-418X ; 0000-0003-4524-8782 ; 0000-0002-8406-0793 ; 0000-0001-6222-4753</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00432-022-04021-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00432-022-04021-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35507103$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://uca.hal.science/hal-03737646$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Grain, Audrey</creatorcontrib><creatorcontrib>Rialland-Battisti, Fanny</creatorcontrib><creatorcontrib>Chevallier, Patrice</creatorcontrib><creatorcontrib>Blin, Nicolas</creatorcontrib><creatorcontrib>Dalle, Jean-Hugues</creatorcontrib><creatorcontrib>Michel, Gérard</creatorcontrib><creatorcontrib>Dhédin, Nathalie</creatorcontrib><creatorcontrib>Peffault de Latour, Regis</creatorcontrib><creatorcontrib>Pochon, Cécile</creatorcontrib><creatorcontrib>Yakoub-Agha, Ibrahim</creatorcontrib><creatorcontrib>Bertrand, Yves</creatorcontrib><creatorcontrib>Sirvent, Anne</creatorcontrib><creatorcontrib>Jubert, Charlotte</creatorcontrib><creatorcontrib>Forcade, Edouard</creatorcontrib><creatorcontrib>Berceanu, Ana</creatorcontrib><creatorcontrib>Gandemer, Virginie</creatorcontrib><creatorcontrib>Schneider, Pascale</creatorcontrib><creatorcontrib>Bay, Jacques-Olivier</creatorcontrib><creatorcontrib>Rohrlich, Pierre-Simon</creatorcontrib><creatorcontrib>Brissot, Eolia</creatorcontrib><creatorcontrib>Paillard, Catherine</creatorcontrib><creatorcontrib>Plantaz, Dominique</creatorcontrib><creatorcontrib>Nguyen Quoc, Stéphanie</creatorcontrib><creatorcontrib>Gonzales, Fanny</creatorcontrib><creatorcontrib>Maillard, Natacha</creatorcontrib><creatorcontrib>Planche, Lucie</creatorcontrib><creatorcontrib>Baruchel, André</creatorcontrib><title>Hematopoietic stem cell transplantation for acute lymphoblastic leukemia: why do adolescents and young adults outcomes differ from those of children? A retrospective study on behalf of the Francophone Society of Stem Cell Transplantation and Cellular Therapy (SFGM-TC)</title><title>Journal of cancer research and clinical oncology</title><addtitle>J Cancer Res Clin Oncol</addtitle><addtitle>J Cancer Res Clin Oncol</addtitle><description>Purpose
In the acute lymphoblastic leukemia (ALL) landscape, adolescents and young adults (AYA) often present high-risk diseases and increased chemotherapy-related toxicity. Studies analyzing the outcomes of AYA after hematopoietic stem cell transplantation (HSCT) are scarce. Our study aimed to compare the outcomes of children and AYA with ALL after HSCT and to determine the factors influencing potential differences.
Method
891 patients, from the SFGM-TC registry, aged between 1 and 25 years who received HSCT between 2005 and 2012 were included. The outcomes of AYA were compared to the ones of their younger counterparts.
Results
Five-year OS and GRFS were lower in AYA: 53.1% versus 64% and 36% versus 47% (
p
= 0.0012 and
p
= 0.007, respectively). WhileCIR was similar in both groups, 5 year-treatment related mortality was higher in AYA: 19% versus 13% (
p
= 0.04). The lower GRFS in AYA was mainly explained by a higher chronic graft versus host disease (cGvHD) incidence: 32% versus 19% (
p
< 0.001). Use of peripheral blood stem cells and use of anti-thymoglobulin appeared to be the main factors impacting cGvHD occurrence in AYA.
Conclusion
AYA have worse outcomes than children after HSCT for ALL because of a greater risk of TRM due to cGvHD. HSCT practices should be questioned in this population.</description><subject>Acute lymphoblastic leukemia</subject><subject>Adolescent</subject><subject>Adolescents</subject><subject>Adult</subject><subject>Cancer Research</subject><subject>Cell therapy</subject><subject>Chemotherapy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Graft vs Host Disease</subject><subject>Graft vs Host Disease - epidemiology</subject><subject>Graft-versus-host reaction</subject><subject>Hematology</subject><subject>Hematopoietic Stem Cell Transplantation</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Hematopoietic stem cells</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Infant</subject><subject>Internal Medicine</subject><subject>Leukemia</subject><subject>Life Sciences</subject><subject>Lymphatic leukemia</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Original Article – Clinical Oncology</subject><subject>Peripheral blood</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy</subject><subject>Retrospective Studies</subject><subject>Stem cell transplantation</subject><subject>Thymoglobulin</subject><subject>Toxicity</subject><subject>Young Adult</subject><subject>Young adults</subject><issn>0171-5216</issn><issn>1432-1335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9UsFu1DAUDAhEl5Yf4ICexIUeAnacrFMuaLViu0iLOOxyjrz2c5PixKntFOXvsdlSJA4cIsfvzRvP2JNlryl5TwnhHzwhJStyUsSvJAXN6dNsQVOJMlY9yxaEcppXBV2eZS-9vyVxX_HiRXbGqopwStjiycUWexHsaDsMnQQfsAeJxkBwYvCjEUMQobMDaOtAyCkgmLkfW3s0wqcJg9MP7DvxEX62MygLQlmDXuIQPIhBwWyn4SZWJxMLdgrS9uhBdVqjA-1sD6G1HsFqkG1nlMPhE6zAYXDWjyhDd49R16RmiDKO2AqjEzi0CJsoUtqoZkDYWxk9zKm1Ty7WycXhHxdJUGpMRjg4tOjEOMO7_eb6a35YX15kz7UwHl89rOfZ983nw3qb775df1mvdrksKxbymkutFC-rEstaXWmpRSmPlJVKEM2vVPwXsmZHRiVFlLxQtV7W1VJUNRY1L9l5dnnijV6a0XW9cHNjRddsV7sm1QjjjC_L5T2N2Lcn7Ojs3YQ-NLd2ckOU1xQ8kpXxIROqOKFkvDTvUD_SUtKksDSnsDQxLM3vsDRp6M0D9XTsUT2O_ElHBLATwMfWcIPu79n_of0FyIXPdg</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Grain, Audrey</creator><creator>Rialland-Battisti, Fanny</creator><creator>Chevallier, Patrice</creator><creator>Blin, Nicolas</creator><creator>Dalle, Jean-Hugues</creator><creator>Michel, Gérard</creator><creator>Dhédin, Nathalie</creator><creator>Peffault de Latour, Regis</creator><creator>Pochon, Cécile</creator><creator>Yakoub-Agha, Ibrahim</creator><creator>Bertrand, Yves</creator><creator>Sirvent, Anne</creator><creator>Jubert, Charlotte</creator><creator>Forcade, Edouard</creator><creator>Berceanu, Ana</creator><creator>Gandemer, Virginie</creator><creator>Schneider, Pascale</creator><creator>Bay, Jacques-Olivier</creator><creator>Rohrlich, Pierre-Simon</creator><creator>Brissot, Eolia</creator><creator>Paillard, Catherine</creator><creator>Plantaz, Dominique</creator><creator>Nguyen Quoc, Stéphanie</creator><creator>Gonzales, Fanny</creator><creator>Maillard, Natacha</creator><creator>Planche, Lucie</creator><creator>Baruchel, André</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><general>Springer Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0003-1547-8229</orcidid><orcidid>https://orcid.org/0000-0002-7032-5180</orcidid><orcidid>https://orcid.org/0000-0001-8801-4164</orcidid><orcidid>https://orcid.org/0000-0003-4471-418X</orcidid><orcidid>https://orcid.org/0000-0003-4524-8782</orcidid><orcidid>https://orcid.org/0000-0002-8406-0793</orcidid><orcidid>https://orcid.org/0000-0001-6222-4753</orcidid></search><sort><creationdate>20230401</creationdate><title>Hematopoietic stem cell transplantation for acute lymphoblastic leukemia: why do adolescents and young adults outcomes differ from those of children? A retrospective study on behalf of the Francophone Society of Stem Cell Transplantation and Cellular Therapy (SFGM-TC)</title><author>Grain, Audrey ; Rialland-Battisti, Fanny ; Chevallier, Patrice ; Blin, Nicolas ; Dalle, Jean-Hugues ; Michel, Gérard ; Dhédin, Nathalie ; Peffault de Latour, Regis ; Pochon, Cécile ; Yakoub-Agha, Ibrahim ; Bertrand, Yves ; Sirvent, Anne ; Jubert, Charlotte ; Forcade, Edouard ; Berceanu, Ana ; Gandemer, Virginie ; Schneider, Pascale ; Bay, Jacques-Olivier ; Rohrlich, Pierre-Simon ; Brissot, Eolia ; Paillard, Catherine ; Plantaz, Dominique ; Nguyen Quoc, Stéphanie ; Gonzales, Fanny ; Maillard, Natacha ; Planche, Lucie ; Baruchel, André</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-87cfdd7454e48d9fcfa4cb134da0f79dcb1ac83b31c1eec72d8f6856a58e28743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acute lymphoblastic leukemia</topic><topic>Adolescent</topic><topic>Adolescents</topic><topic>Adult</topic><topic>Cancer Research</topic><topic>Cell therapy</topic><topic>Chemotherapy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Graft vs Host Disease</topic><topic>Graft vs Host Disease - epidemiology</topic><topic>Graft-versus-host reaction</topic><topic>Hematology</topic><topic>Hematopoietic Stem Cell Transplantation</topic><topic>Hematopoietic Stem Cell Transplantation - adverse effects</topic><topic>Hematopoietic stem cells</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Infant</topic><topic>Internal Medicine</topic><topic>Leukemia</topic><topic>Life Sciences</topic><topic>Lymphatic leukemia</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Original Article – Clinical Oncology</topic><topic>Peripheral blood</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy</topic><topic>Retrospective Studies</topic><topic>Stem cell transplantation</topic><topic>Thymoglobulin</topic><topic>Toxicity</topic><topic>Young Adult</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grain, Audrey</creatorcontrib><creatorcontrib>Rialland-Battisti, Fanny</creatorcontrib><creatorcontrib>Chevallier, Patrice</creatorcontrib><creatorcontrib>Blin, Nicolas</creatorcontrib><creatorcontrib>Dalle, Jean-Hugues</creatorcontrib><creatorcontrib>Michel, Gérard</creatorcontrib><creatorcontrib>Dhédin, Nathalie</creatorcontrib><creatorcontrib>Peffault de Latour, Regis</creatorcontrib><creatorcontrib>Pochon, Cécile</creatorcontrib><creatorcontrib>Yakoub-Agha, Ibrahim</creatorcontrib><creatorcontrib>Bertrand, Yves</creatorcontrib><creatorcontrib>Sirvent, Anne</creatorcontrib><creatorcontrib>Jubert, Charlotte</creatorcontrib><creatorcontrib>Forcade, Edouard</creatorcontrib><creatorcontrib>Berceanu, Ana</creatorcontrib><creatorcontrib>Gandemer, Virginie</creatorcontrib><creatorcontrib>Schneider, Pascale</creatorcontrib><creatorcontrib>Bay, Jacques-Olivier</creatorcontrib><creatorcontrib>Rohrlich, Pierre-Simon</creatorcontrib><creatorcontrib>Brissot, Eolia</creatorcontrib><creatorcontrib>Paillard, Catherine</creatorcontrib><creatorcontrib>Plantaz, Dominique</creatorcontrib><creatorcontrib>Nguyen Quoc, Stéphanie</creatorcontrib><creatorcontrib>Gonzales, Fanny</creatorcontrib><creatorcontrib>Maillard, Natacha</creatorcontrib><creatorcontrib>Planche, Lucie</creatorcontrib><creatorcontrib>Baruchel, André</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central 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Audrey</au><au>Rialland-Battisti, Fanny</au><au>Chevallier, Patrice</au><au>Blin, Nicolas</au><au>Dalle, Jean-Hugues</au><au>Michel, Gérard</au><au>Dhédin, Nathalie</au><au>Peffault de Latour, Regis</au><au>Pochon, Cécile</au><au>Yakoub-Agha, Ibrahim</au><au>Bertrand, Yves</au><au>Sirvent, Anne</au><au>Jubert, Charlotte</au><au>Forcade, Edouard</au><au>Berceanu, Ana</au><au>Gandemer, Virginie</au><au>Schneider, Pascale</au><au>Bay, Jacques-Olivier</au><au>Rohrlich, Pierre-Simon</au><au>Brissot, Eolia</au><au>Paillard, Catherine</au><au>Plantaz, Dominique</au><au>Nguyen Quoc, Stéphanie</au><au>Gonzales, Fanny</au><au>Maillard, Natacha</au><au>Planche, Lucie</au><au>Baruchel, André</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hematopoietic stem cell transplantation for acute lymphoblastic leukemia: why do adolescents and young adults outcomes differ from those of children? A retrospective study on behalf of the Francophone Society of Stem Cell Transplantation and Cellular Therapy (SFGM-TC)</atitle><jtitle>Journal of cancer research and clinical oncology</jtitle><stitle>J Cancer Res Clin Oncol</stitle><addtitle>J Cancer Res Clin Oncol</addtitle><date>2023-04-01</date><risdate>2023</risdate><volume>149</volume><issue>4</issue><spage>1473</spage><epage>1483</epage><pages>1473-1483</pages><issn>0171-5216</issn><eissn>1432-1335</eissn><abstract>Purpose
In the acute lymphoblastic leukemia (ALL) landscape, adolescents and young adults (AYA) often present high-risk diseases and increased chemotherapy-related toxicity. Studies analyzing the outcomes of AYA after hematopoietic stem cell transplantation (HSCT) are scarce. Our study aimed to compare the outcomes of children and AYA with ALL after HSCT and to determine the factors influencing potential differences.
Method
891 patients, from the SFGM-TC registry, aged between 1 and 25 years who received HSCT between 2005 and 2012 were included. The outcomes of AYA were compared to the ones of their younger counterparts.
Results
Five-year OS and GRFS were lower in AYA: 53.1% versus 64% and 36% versus 47% (
p
= 0.0012 and
p
= 0.007, respectively). WhileCIR was similar in both groups, 5 year-treatment related mortality was higher in AYA: 19% versus 13% (
p
= 0.04). The lower GRFS in AYA was mainly explained by a higher chronic graft versus host disease (cGvHD) incidence: 32% versus 19% (
p
< 0.001). Use of peripheral blood stem cells and use of anti-thymoglobulin appeared to be the main factors impacting cGvHD occurrence in AYA.
Conclusion
AYA have worse outcomes than children after HSCT for ALL because of a greater risk of TRM due to cGvHD. HSCT practices should be questioned in this population.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35507103</pmid><doi>10.1007/s00432-022-04021-1</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-1547-8229</orcidid><orcidid>https://orcid.org/0000-0002-7032-5180</orcidid><orcidid>https://orcid.org/0000-0001-8801-4164</orcidid><orcidid>https://orcid.org/0000-0003-4471-418X</orcidid><orcidid>https://orcid.org/0000-0003-4524-8782</orcidid><orcidid>https://orcid.org/0000-0002-8406-0793</orcidid><orcidid>https://orcid.org/0000-0001-6222-4753</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0171-5216 |
| ispartof | Journal of cancer research and clinical oncology, 2023-04, Vol.149 (4), p.1473-1483 |
| issn | 0171-5216 1432-1335 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_03737646v1 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Acute lymphoblastic leukemia Adolescent Adolescents Adult Cancer Research Cell therapy Chemotherapy Child Child, Preschool Children Graft vs Host Disease Graft vs Host Disease - epidemiology Graft-versus-host reaction Hematology Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic stem cells Human health and pathology Humans Infant Internal Medicine Leukemia Life Sciences Lymphatic leukemia Medicine Medicine & Public Health Oncology Original Article – Clinical Oncology Peripheral blood Precursor Cell Lymphoblastic Leukemia-Lymphoma Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy Retrospective Studies Stem cell transplantation Thymoglobulin Toxicity Young Adult Young adults |
| title | Hematopoietic stem cell transplantation for acute lymphoblastic leukemia: why do adolescents and young adults outcomes differ from those of children? A retrospective study on behalf of the Francophone Society of Stem Cell Transplantation and Cellular Therapy (SFGM-TC) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T17%3A45%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hematopoietic%20stem%20cell%20transplantation%20for%20acute%20lymphoblastic%20leukemia:%20why%20do%20adolescents%20and%20young%20adults%20outcomes%20differ%20from%20those%20of%20children?%20A%20retrospective%20study%20on%20behalf%20of%20the%20Francophone%20Society%20of%20Stem%20Cell%20Transplantation%20and%20Cellular%20Therapy%20(SFGM-TC)&rft.jtitle=Journal%20of%20cancer%20research%20and%20clinical%20oncology&rft.au=Grain,%20Audrey&rft.date=2023-04-01&rft.volume=149&rft.issue=4&rft.spage=1473&rft.epage=1483&rft.pages=1473-1483&rft.issn=0171-5216&rft.eissn=1432-1335&rft_id=info:doi/10.1007/s00432-022-04021-1&rft_dat=%3Cproquest_hal_p%3E2787440711%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2787440711&rft_id=info:pmid/35507103&rfr_iscdi=true |