Antimicrobial properties of the equine α-defensin DEFA1 against bacterial horse pathogens

Defensins are small effector molecules of the innate immune system, synthesised by various organisms including plants and animals. The peptides act as endogenous antibiotics with an antimicrobial activity against a broad spectrum of microbes including bacteria, fungi and viruses. α-Defensins are a s...

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Veröffentlicht in:	Veterinary immunology and immunopathology 2009-07, Vol.130 (1), p.102-106
Hauptverfasser:	Bruhn, O., Cauchard, J., Schlusselhuber, M., Gelhaus, C., Podschun, R., Thaller, G., Laugier, C., Leippe, M., Grötzinger, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinomycetales Infections - drug therapy Actinomycetales Infections - microbiology Actinomycetales Infections - veterinary alpha-defensin alpha-Defensins - pharmacology Amino Acid Sequence Animals Anti-Infective Agents - pharmacology antibacterial properties Antimicrobial antimicrobial agents bacterial infections bioassays DEFA1 Defensin defensins disease resistance Horse horse diseases Horse Diseases - drug therapy Horse Diseases - microbiology Horses immunotherapy in vitro studies lethal dose Life Sciences Microbial Sensitivity Tests - veterinary minimum inhibitory concentration Molecular Sequence Data Pasteurella multocida Pasteurella multocida - drug effects Pasteurella multocida - growth & development peptides Recombinant Proteins - pharmacology Rhodococcus equi Rhodococcus equi - drug effects Rhodococcus equi - growth & development Rhodococcus equi - isolation & purification Salmonella - drug effects Salmonella - growth & development Salmonella enterica subsp. enterica serovar Typhimurium strains Streptococcus - drug effects Streptococcus - growth & development Streptococcus dysgalactiae subsp. equisimilis Streptococcus equi subsp. zooepidemicus
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