Stimuli‐Responsive Metal Complexes for Biomedical Applications
Metal‐based compounds have been widely used for biomedical applications. Their unique characteristics make them attractive for both therapeutic and diagnostic purposes. However, numerous issues including toxicity, poor aqueous solubility, and unfavorable biodistribution hamper their widespread use....
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| Veröffentlicht in: | Angewandte Chemie International Edition 2022-10, Vol.61 (40), p.e202205900-n/a |
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| creator | Amarsy, Ivanna Papot, Sébastien Gasser, Gilles |
| description | Metal‐based compounds have been widely used for biomedical applications. Their unique characteristics make them attractive for both therapeutic and diagnostic purposes. However, numerous issues including toxicity, poor aqueous solubility, and unfavorable biodistribution hamper their widespread use. To overcome these drawbacks, the concept of metal‐based prodrugs emerged. This field is particularly developed for applications in oncology. More precisely, tumor‐associated stimuli (e.g., pH variation, redox activity, enzyme overexpression, etc.) have been exploited to trigger the selective delivery of active metal‐based drugs to the tumor site. The main advances in this area are discussed in this Review.
Let's make metal‐based drugs more selective! Metal‐based compounds have been widely used for biomedical applications. Their unique characteristics make them attractive for both therapeutic and diagnostic purposes. However, numerous issues including toxicity, poor aqueous solubility, and unfavorable biodistribution hamper their widespread use. To overcome these drawbacks, the concept of metal‐based prodrugs emerged. The main advances in the use of metal‐based prodrugs are discussed in this Review. |
| doi_str_mv | 10.1002/anie.202205900 |
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Let's make metal‐based drugs more selective! Metal‐based compounds have been widely used for biomedical applications. Their unique characteristics make them attractive for both therapeutic and diagnostic purposes. However, numerous issues including toxicity, poor aqueous solubility, and unfavorable biodistribution hamper their widespread use. To overcome these drawbacks, the concept of metal‐based prodrugs emerged. The main advances in the use of metal‐based prodrugs are discussed in this Review.</description><edition>International ed. in English</edition><identifier>ISSN: 1433-7851</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.202205900</identifier><language>eng</language><publisher>Weinheim: Wiley Subscription Services, Inc</publisher><subject>Biocompatibility ; Biomedical materials ; Chemical Sciences ; Coordination compounds ; diagnostic tools ; drug release ; Medicinal Chemistry ; medicinal inorganic chemistry ; Metal complexes ; metals in medicine ; selective delivery ; Stimuli ; Toxicity ; Tumors</subject><ispartof>Angewandte Chemie International Edition, 2022-10, Vol.61 (40), p.e202205900-n/a</ispartof><rights>2022 Wiley‐VCH GmbH</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4240-a98e56a34fac753c419b573145d993efd2e66ddce49dc8cc1fdea16bd067ddf53</citedby><cites>FETCH-LOGICAL-c4240-a98e56a34fac753c419b573145d993efd2e66ddce49dc8cc1fdea16bd067ddf53</cites><orcidid>0000-0002-4244-5097 ; 0000-0001-5253-1979</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fanie.202205900$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fanie.202205900$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://hal.science/hal-03713992$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Amarsy, Ivanna</creatorcontrib><creatorcontrib>Papot, Sébastien</creatorcontrib><creatorcontrib>Gasser, Gilles</creatorcontrib><title>Stimuli‐Responsive Metal Complexes for Biomedical Applications</title><title>Angewandte Chemie International Edition</title><description>Metal‐based compounds have been widely used for biomedical applications. Their unique characteristics make them attractive for both therapeutic and diagnostic purposes. However, numerous issues including toxicity, poor aqueous solubility, and unfavorable biodistribution hamper their widespread use. To overcome these drawbacks, the concept of metal‐based prodrugs emerged. This field is particularly developed for applications in oncology. More precisely, tumor‐associated stimuli (e.g., pH variation, redox activity, enzyme overexpression, etc.) have been exploited to trigger the selective delivery of active metal‐based drugs to the tumor site. The main advances in this area are discussed in this Review.
Let's make metal‐based drugs more selective! Metal‐based compounds have been widely used for biomedical applications. Their unique characteristics make them attractive for both therapeutic and diagnostic purposes. However, numerous issues including toxicity, poor aqueous solubility, and unfavorable biodistribution hamper their widespread use. To overcome these drawbacks, the concept of metal‐based prodrugs emerged. The main advances in the use of metal‐based prodrugs are discussed in this Review.</description><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Chemical Sciences</subject><subject>Coordination compounds</subject><subject>diagnostic tools</subject><subject>drug release</subject><subject>Medicinal Chemistry</subject><subject>medicinal inorganic chemistry</subject><subject>Metal complexes</subject><subject>metals in medicine</subject><subject>selective delivery</subject><subject>Stimuli</subject><subject>Toxicity</subject><subject>Tumors</subject><issn>1433-7851</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqF0MtOAyEUBuCJ0cR62bpu4kYXU7kMMOysTdUmVRMva4JwJtIwZRw6VXc-gs_ok0hTo4kbV5zA9xP4s-wAowFGiJzouYMBQYQgJhHayHqYEZxTIehmmgtKc1EyvJ3txDhLviwR72WndwtXd959vn_cQmzCPLol9K9goX1_FOrGwyvEfhXa_pkLNVhn0sGwaXwaFi7xvWyr0j7C_ve6mz2cj-9Hl_n05mIyGk5zU5AC5VqWwLimRaWNYNQUWD4yQXHBrJQUKkuAc2sNFNKa0hhcWdCYP1rEhbUVo7vZ8freJ-1V07pat28qaKcuh1O12kNUYColWeJkj9a2acNzB3GhahcNeK_nELqoCC8ZooxTnujhHzoLXTtPP1FEYFEKUrCVGqyVaUOMLVQ_L8BIrcpXq_LVT_kpINeBF-fh7R-thteT8W_2CzcfiKc</recordid><startdate>20221004</startdate><enddate>20221004</enddate><creator>Amarsy, Ivanna</creator><creator>Papot, Sébastien</creator><creator>Gasser, Gilles</creator><general>Wiley Subscription Services, Inc</general><general>Wiley-VCH Verlag</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0002-4244-5097</orcidid><orcidid>https://orcid.org/0000-0001-5253-1979</orcidid></search><sort><creationdate>20221004</creationdate><title>Stimuli‐Responsive Metal Complexes for Biomedical Applications</title><author>Amarsy, Ivanna ; Papot, Sébastien ; Gasser, Gilles</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4240-a98e56a34fac753c419b573145d993efd2e66ddce49dc8cc1fdea16bd067ddf53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Chemical Sciences</topic><topic>Coordination compounds</topic><topic>diagnostic tools</topic><topic>drug release</topic><topic>Medicinal Chemistry</topic><topic>medicinal inorganic chemistry</topic><topic>Metal complexes</topic><topic>metals in medicine</topic><topic>selective delivery</topic><topic>Stimuli</topic><topic>Toxicity</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amarsy, Ivanna</creatorcontrib><creatorcontrib>Papot, Sébastien</creatorcontrib><creatorcontrib>Gasser, Gilles</creatorcontrib><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Angewandte Chemie International Edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amarsy, Ivanna</au><au>Papot, Sébastien</au><au>Gasser, Gilles</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stimuli‐Responsive Metal Complexes for Biomedical Applications</atitle><jtitle>Angewandte Chemie International Edition</jtitle><date>2022-10-04</date><risdate>2022</risdate><volume>61</volume><issue>40</issue><spage>e202205900</spage><epage>n/a</epage><pages>e202205900-n/a</pages><issn>1433-7851</issn><eissn>1521-3773</eissn><abstract>Metal‐based compounds have been widely used for biomedical applications. Their unique characteristics make them attractive for both therapeutic and diagnostic purposes. However, numerous issues including toxicity, poor aqueous solubility, and unfavorable biodistribution hamper their widespread use. To overcome these drawbacks, the concept of metal‐based prodrugs emerged. This field is particularly developed for applications in oncology. More precisely, tumor‐associated stimuli (e.g., pH variation, redox activity, enzyme overexpression, etc.) have been exploited to trigger the selective delivery of active metal‐based drugs to the tumor site. The main advances in this area are discussed in this Review.
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Biocompatibility Biomedical materials Chemical Sciences Coordination compounds diagnostic tools drug release Medicinal Chemistry medicinal inorganic chemistry Metal complexes metals in medicine selective delivery Stimuli Toxicity Tumors |
| title | Stimuli‐Responsive Metal Complexes for Biomedical Applications |
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