Cationic porphyrin–xylan conjugate hydrogels for photodynamic antimicrobial chemotherapy
Bio‐based hydrogels are attractive materials for many biomedical purposes such as drug delivery or wound healing. A light‐triggered antibacterial activity can be conferred to hydrogels after their conjugation to appropriate photosensitizers (PS). In this study, we have synthesized and characterized...
Gespeichert in:
| Veröffentlicht in: | Journal of applied polymer science 2022-10, Vol.139 (38), p.n/a |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | n/a |
|---|---|
| container_issue | 38 |
| container_start_page | |
| container_title | Journal of applied polymer science |
| container_volume | 139 |
| creator | Elkihel, Abdechakour Vernisse, Charlotte Ouk, Tan‐Sothéa Lucas, Romain Chaleix, Vincent Sol, Vincent |
| description | Bio‐based hydrogels are attractive materials for many biomedical purposes such as drug delivery or wound healing. A light‐triggered antibacterial activity can be conferred to hydrogels after their conjugation to appropriate photosensitizers (PS). In this study, we have synthesized and characterized hydrogels consisting of cationic porphyrin–xylan conjugates. A cationic porphyrin was covalently attached to xylan by an esterification reaction. Different porphyrin‐xylan derivatives were obtained with degrees of substitution ranging from 0.003 to 0.053. Then, the derivatives were cross‐linked after reaction with diethylenetriaminepentaacetic (DTPA) dianhydride to obtain the corresponding hydrogels. The study of the morphology and rheology of the hydrogels showed that the materials obtained present interconnected porous structures, good mechanical integrities as well as high swelling ratios. Antimicrobial activity of cationic porphyrin–xylan conjugate hydrogels was tested under white light irradiation against Staphylococcus aureus and Pseudomonas aeruginosa. All of the tested hydrogels showed photo‐bactericidal activity against the two tested strains. |
| doi_str_mv | 10.1002/app.52744 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_03706759v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2708690778</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2614-a66917143428a3452b1391c80856ba6ae2f2969ae84e85fdc2febab222ae3b783</originalsourceid><addsrcrecordid>eNp1kLFOwzAURS0EEqUw8AeRmBjS2o7j2GNVAUWqBAMsLNZL6jSu0tg4KZCNf-AP-RJcghAL05XeO_fqvYvQOcETgjGdgnOTlGaMHaARwTKLGafiEI3CjsRCyvQYnbTtBmNCUsxH6GkOnbGNKSJnvat6b5rP94-3voYmKmyz2a2h01HVr7xd67qNSusjV9nOrvoGtsEGTWeCepsbqKOi0lvbVdqD60_RUQl1q89-dIwer68e5ot4eXdzO58t44JywmLgXJKMsIRRAQlLaU4SSQqBRcpz4KBpSSWXoAXTIi1XBS11DjmlFHSSZyIZo8sht4JaOW-24HtlwajFbKn2M5xkmGepfCGBvRhY5-3zTred2tidb8J5imZYcImzv4nhrbb1uvyNJVjta1ahZvVdc2CnA_tqat3_D6rZ_f3g-AJDRoBP</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2708690778</pqid></control><display><type>article</type><title>Cationic porphyrin–xylan conjugate hydrogels for photodynamic antimicrobial chemotherapy</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Elkihel, Abdechakour ; Vernisse, Charlotte ; Ouk, Tan‐Sothéa ; Lucas, Romain ; Chaleix, Vincent ; Sol, Vincent</creator><creatorcontrib>Elkihel, Abdechakour ; Vernisse, Charlotte ; Ouk, Tan‐Sothéa ; Lucas, Romain ; Chaleix, Vincent ; Sol, Vincent</creatorcontrib><description>Bio‐based hydrogels are attractive materials for many biomedical purposes such as drug delivery or wound healing. A light‐triggered antibacterial activity can be conferred to hydrogels after their conjugation to appropriate photosensitizers (PS). In this study, we have synthesized and characterized hydrogels consisting of cationic porphyrin–xylan conjugates. A cationic porphyrin was covalently attached to xylan by an esterification reaction. Different porphyrin‐xylan derivatives were obtained with degrees of substitution ranging from 0.003 to 0.053. Then, the derivatives were cross‐linked after reaction with diethylenetriaminepentaacetic (DTPA) dianhydride to obtain the corresponding hydrogels. The study of the morphology and rheology of the hydrogels showed that the materials obtained present interconnected porous structures, good mechanical integrities as well as high swelling ratios. Antimicrobial activity of cationic porphyrin–xylan conjugate hydrogels was tested under white light irradiation against Staphylococcus aureus and Pseudomonas aeruginosa. All of the tested hydrogels showed photo‐bactericidal activity against the two tested strains.</description><identifier>ISSN: 0021-8995</identifier><identifier>EISSN: 1097-4628</identifier><identifier>DOI: 10.1002/app.52744</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Biomedical materials ; Cancer ; Cations ; cellulose and other wood products ; Chemical Sciences ; Conjugates ; Conjugation ; drug delivery systems ; dyes/pigments ; Esterification ; functionalization of polymers ; grafting ; Hydrogels ; Life Sciences ; Light irradiation ; Materials science ; Organic chemistry ; Polymers ; Porous materials ; Porphyrins ; Pseudomonas aeruginosa ; Rheological properties ; Rheology ; Substitution reactions ; Swelling ratio ; White light ; Wound healing</subject><ispartof>Journal of applied polymer science, 2022-10, Vol.139 (38), p.n/a</ispartof><rights>2022 Wiley Periodicals LLC.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2614-a66917143428a3452b1391c80856ba6ae2f2969ae84e85fdc2febab222ae3b783</citedby><cites>FETCH-LOGICAL-c2614-a66917143428a3452b1391c80856ba6ae2f2969ae84e85fdc2febab222ae3b783</cites><orcidid>0000-0003-0175-0156</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fapp.52744$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fapp.52744$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://hal.science/hal-03706759$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Elkihel, Abdechakour</creatorcontrib><creatorcontrib>Vernisse, Charlotte</creatorcontrib><creatorcontrib>Ouk, Tan‐Sothéa</creatorcontrib><creatorcontrib>Lucas, Romain</creatorcontrib><creatorcontrib>Chaleix, Vincent</creatorcontrib><creatorcontrib>Sol, Vincent</creatorcontrib><title>Cationic porphyrin–xylan conjugate hydrogels for photodynamic antimicrobial chemotherapy</title><title>Journal of applied polymer science</title><description>Bio‐based hydrogels are attractive materials for many biomedical purposes such as drug delivery or wound healing. A light‐triggered antibacterial activity can be conferred to hydrogels after their conjugation to appropriate photosensitizers (PS). In this study, we have synthesized and characterized hydrogels consisting of cationic porphyrin–xylan conjugates. A cationic porphyrin was covalently attached to xylan by an esterification reaction. Different porphyrin‐xylan derivatives were obtained with degrees of substitution ranging from 0.003 to 0.053. Then, the derivatives were cross‐linked after reaction with diethylenetriaminepentaacetic (DTPA) dianhydride to obtain the corresponding hydrogels. The study of the morphology and rheology of the hydrogels showed that the materials obtained present interconnected porous structures, good mechanical integrities as well as high swelling ratios. Antimicrobial activity of cationic porphyrin–xylan conjugate hydrogels was tested under white light irradiation against Staphylococcus aureus and Pseudomonas aeruginosa. All of the tested hydrogels showed photo‐bactericidal activity against the two tested strains.</description><subject>Biomedical materials</subject><subject>Cancer</subject><subject>Cations</subject><subject>cellulose and other wood products</subject><subject>Chemical Sciences</subject><subject>Conjugates</subject><subject>Conjugation</subject><subject>drug delivery systems</subject><subject>dyes/pigments</subject><subject>Esterification</subject><subject>functionalization of polymers</subject><subject>grafting</subject><subject>Hydrogels</subject><subject>Life Sciences</subject><subject>Light irradiation</subject><subject>Materials science</subject><subject>Organic chemistry</subject><subject>Polymers</subject><subject>Porous materials</subject><subject>Porphyrins</subject><subject>Pseudomonas aeruginosa</subject><subject>Rheological properties</subject><subject>Rheology</subject><subject>Substitution reactions</subject><subject>Swelling ratio</subject><subject>White light</subject><subject>Wound healing</subject><issn>0021-8995</issn><issn>1097-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1kLFOwzAURS0EEqUw8AeRmBjS2o7j2GNVAUWqBAMsLNZL6jSu0tg4KZCNf-AP-RJcghAL05XeO_fqvYvQOcETgjGdgnOTlGaMHaARwTKLGafiEI3CjsRCyvQYnbTtBmNCUsxH6GkOnbGNKSJnvat6b5rP94-3voYmKmyz2a2h01HVr7xd67qNSusjV9nOrvoGtsEGTWeCepsbqKOi0lvbVdqD60_RUQl1q89-dIwer68e5ot4eXdzO58t44JywmLgXJKMsIRRAQlLaU4SSQqBRcpz4KBpSSWXoAXTIi1XBS11DjmlFHSSZyIZo8sht4JaOW-24HtlwajFbKn2M5xkmGepfCGBvRhY5-3zTred2tidb8J5imZYcImzv4nhrbb1uvyNJVjta1ahZvVdc2CnA_tqat3_D6rZ_f3g-AJDRoBP</recordid><startdate>20221010</startdate><enddate>20221010</enddate><creator>Elkihel, Abdechakour</creator><creator>Vernisse, Charlotte</creator><creator>Ouk, Tan‐Sothéa</creator><creator>Lucas, Romain</creator><creator>Chaleix, Vincent</creator><creator>Sol, Vincent</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><general>Wiley</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0003-0175-0156</orcidid></search><sort><creationdate>20221010</creationdate><title>Cationic porphyrin–xylan conjugate hydrogels for photodynamic antimicrobial chemotherapy</title><author>Elkihel, Abdechakour ; Vernisse, Charlotte ; Ouk, Tan‐Sothéa ; Lucas, Romain ; Chaleix, Vincent ; Sol, Vincent</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2614-a66917143428a3452b1391c80856ba6ae2f2969ae84e85fdc2febab222ae3b783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biomedical materials</topic><topic>Cancer</topic><topic>Cations</topic><topic>cellulose and other wood products</topic><topic>Chemical Sciences</topic><topic>Conjugates</topic><topic>Conjugation</topic><topic>drug delivery systems</topic><topic>dyes/pigments</topic><topic>Esterification</topic><topic>functionalization of polymers</topic><topic>grafting</topic><topic>Hydrogels</topic><topic>Life Sciences</topic><topic>Light irradiation</topic><topic>Materials science</topic><topic>Organic chemistry</topic><topic>Polymers</topic><topic>Porous materials</topic><topic>Porphyrins</topic><topic>Pseudomonas aeruginosa</topic><topic>Rheological properties</topic><topic>Rheology</topic><topic>Substitution reactions</topic><topic>Swelling ratio</topic><topic>White light</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elkihel, Abdechakour</creatorcontrib><creatorcontrib>Vernisse, Charlotte</creatorcontrib><creatorcontrib>Ouk, Tan‐Sothéa</creatorcontrib><creatorcontrib>Lucas, Romain</creatorcontrib><creatorcontrib>Chaleix, Vincent</creatorcontrib><creatorcontrib>Sol, Vincent</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Journal of applied polymer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elkihel, Abdechakour</au><au>Vernisse, Charlotte</au><au>Ouk, Tan‐Sothéa</au><au>Lucas, Romain</au><au>Chaleix, Vincent</au><au>Sol, Vincent</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cationic porphyrin–xylan conjugate hydrogels for photodynamic antimicrobial chemotherapy</atitle><jtitle>Journal of applied polymer science</jtitle><date>2022-10-10</date><risdate>2022</risdate><volume>139</volume><issue>38</issue><epage>n/a</epage><issn>0021-8995</issn><eissn>1097-4628</eissn><abstract>Bio‐based hydrogels are attractive materials for many biomedical purposes such as drug delivery or wound healing. A light‐triggered antibacterial activity can be conferred to hydrogels after their conjugation to appropriate photosensitizers (PS). In this study, we have synthesized and characterized hydrogels consisting of cationic porphyrin–xylan conjugates. A cationic porphyrin was covalently attached to xylan by an esterification reaction. Different porphyrin‐xylan derivatives were obtained with degrees of substitution ranging from 0.003 to 0.053. Then, the derivatives were cross‐linked after reaction with diethylenetriaminepentaacetic (DTPA) dianhydride to obtain the corresponding hydrogels. The study of the morphology and rheology of the hydrogels showed that the materials obtained present interconnected porous structures, good mechanical integrities as well as high swelling ratios. Antimicrobial activity of cationic porphyrin–xylan conjugate hydrogels was tested under white light irradiation against Staphylococcus aureus and Pseudomonas aeruginosa. All of the tested hydrogels showed photo‐bactericidal activity against the two tested strains.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><doi>10.1002/app.52744</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-0175-0156</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8995 |
| ispartof | Journal of applied polymer science, 2022-10, Vol.139 (38), p.n/a |
| issn | 0021-8995 1097-4628 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_03706759v1 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Biomedical materials Cancer Cations cellulose and other wood products Chemical Sciences Conjugates Conjugation drug delivery systems dyes/pigments Esterification functionalization of polymers grafting Hydrogels Life Sciences Light irradiation Materials science Organic chemistry Polymers Porous materials Porphyrins Pseudomonas aeruginosa Rheological properties Rheology Substitution reactions Swelling ratio White light Wound healing |
| title | Cationic porphyrin–xylan conjugate hydrogels for photodynamic antimicrobial chemotherapy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T22%3A28%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cationic%20porphyrin%E2%80%93xylan%20conjugate%20hydrogels%20for%20photodynamic%20antimicrobial%20chemotherapy&rft.jtitle=Journal%20of%20applied%20polymer%20science&rft.au=Elkihel,%20Abdechakour&rft.date=2022-10-10&rft.volume=139&rft.issue=38&rft.epage=n/a&rft.issn=0021-8995&rft.eissn=1097-4628&rft_id=info:doi/10.1002/app.52744&rft_dat=%3Cproquest_hal_p%3E2708690778%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2708690778&rft_id=info:pmid/&rfr_iscdi=true |