Mosaic Deficiency in Mitochondrial Oxidative Metabolism Promotes Cardiac Arrhythmia during Aging

Aging is a progressive decline of body function, during which many tissues accumulate few cells with high levels of deleted mitochondrial DNA (mtDNA), leading to a defect of mitochondrial functions. Whether this mosaic mitochondrial deficiency contributes to organ dysfunction is unknown. To investig...

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Veröffentlicht in:	Cell metabolism 2015-05, Vol.21 (5), p.667-677
Hauptverfasser:	Baris, Olivier R., Ederer, Stefan, Neuhaus, Johannes F.G., von Kleist-Retzow, Jürgen-Christoph, Wunderlich, Claudia M., Pal, Martin, Wunderlich, F. Thomas, Peeva, Viktoriya, Zsurka, Gabor, Kunz, Wolfram S., Hickethier, Tilman, Bunck, Alexander C., Stöckigt, Florian, Schrickel, Jan W., Wiesner, Rudolf J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Arrhythmias, Cardiac - etiology Arrhythmias, Cardiac - genetics Arrhythmias, Cardiac - metabolism Arrhythmias, Cardiac - pathology Cell Respiration DNA, Mitochondrial - genetics Electron Transport Complex IV - genetics Electron Transport Complex IV - metabolism Gene Deletion Life Sciences Mice Mitochondria - genetics Mitochondria - metabolism Mitochondria - pathology Mitochondrial Diseases - complications Mitochondrial Diseases - genetics Mitochondrial Diseases - metabolism Mitochondrial Diseases - pathology Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Oxygen - metabolism
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