A phosphoinositide conversion mechanism for exit from endosomes

A mechanism for phosphoinositide conversion at endosomes to enable exit from the endosomal system, suggesting that defective phosphoinositide conversion at endosomes underlies X-linked centronuclear myopathy. Phosphoinositide conversion during endosome exit Directional membrane traffic requires regu...

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Veröffentlicht in:	Nature (London) 2016-01, Vol.529 (7586), p.408-412
Hauptverfasser:	Ketel, Katharina, Krauss, Michael, Nicot, Anne-Sophie, Puchkov, Dmytro, Wieffer, Marnix, Müller, Rainer, Subramanian, Devaraj, Schultz, Carsten, Laporte, Jocelyn, Haucke, Volker
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 4-Kinase - metabolism 631/45/287/1194 631/80/304 631/80/313/1481 631/80/313/1776 Biological Transport Cell Line Cell Membrane - metabolism Cellular biology Endocytosis Endosomes - metabolism Epidermal growth factor Exocytosis Genotype & phenotype Health aspects HeLa Cells Human health and pathology Humanities and Social Sciences Humans Hydrolysis letter Life Sciences Lipids Membrane Fusion Membrane lipids Membranes multidisciplinary Myopathies, Structural, Congenital - enzymology Myopathies, Structural, Congenital - genetics Myopathies, Structural, Congenital - pathology Observations Phosphatase Phosphatidylinositol Phosphates - metabolism Phosphatidylinositols - metabolism Phosphoinositides Phosphoric Monoester Hydrolases - deficiency Phosphoric Monoester Hydrolases - genetics Phosphoric Monoester Hydrolases - metabolism Protein Tyrosine Phosphatases, Non-Receptor - deficiency Protein Tyrosine Phosphatases, Non-Receptor - genetics Protein Tyrosine Phosphatases, Non-Receptor - metabolism Protein-protein interactions Proteins Science
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