PHACTR-1 (Phosphatase and Actin Regulator 1) Deficiency in Either Endothelial or Smooth Muscle Cells Does Not Predispose Mice to Nonatherosclerotic Arteriopathies in 3 Transgenic Mice

Genome-wide association studies have revealed robust associations of common genetic polymorphisms in an intron of the PHACTR-1 (phosphatase and actin regulator 1) gene (chr6p24), with cervical artery dissection, spontaneous coronary artery dissection, and fibromuscular dysplasia. The aim was to asse...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2022-05, Vol.42 (5), p.597-609
Hauptverfasser:	Rubin, Sébastien, Bougaran, Pauline, Martin, Soizic, Abelanet, Alice, Delobel, Valentin, Pernot, Mathieu, Jeanningros, Sylvie, Bats, Marie-Lise, Combe, Christian, Dufourcq, Pascale, Debette, Stéphanie, Couffinhal, Thierry, Duplàa, Cécile
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals Arterial Occlusive Diseases - metabolism Endothelial Cells - metabolism Fibromuscular Dysplasia - genetics Genome-Wide Association Study Human health and pathology Life Sciences Mice Mice, Knockout Mice, Transgenic Microfilament Proteins - genetics Microfilament Proteins - metabolism Myocytes, Smooth Muscle - metabolism Phosphoric Monoester Hydrolases - metabolism
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