Heterogeneity of pollen food allergy syndrome in seven Southern European countries: The @IT.2020 multicenter study
Background Pollen food allergy syndrome (PFAS) is a frequently underdiagnosed disease due to diverse triggers, clinical presentations, and test results. This is especially relevant in geographic areas with a broad spectrum of pollen sensitization, such as Southern Europe. Objectives To elucidate sim...
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| Veröffentlicht in: | Allergy (Copenhagen) 2021-10, Vol.76 (10), p.3041-3052 |
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| creator | Lipp, Theresa Acar Şahin, Aydan Aggelidis, Xenophon Arasi, Stefania Barbalace, Andrea Bourgoin, Anne Bregu, Blerina Brighetti, Maria Antonia Caeiro, Elsa Caglayan Sozmen, Sule Caminiti, Lucia Charpin, Denis Couto, Mariana Delgado, Luís Di Rienzo Businco, Andrea Dimier, Claire Dimou, Maria V. Fonseca, João A. Goksel, Ozlem Guvensen, Aykut Hernandez, Dolores Hoffmann, Tara Maria Jang, Dah Tay Kalpaklioglu, Fusun Lame, Blerta Llusar, Ruth Makris, Michael P. Mazon, Angel Mesonjesi, Eris Nieto, Antonio Öztürk, Ayse Pahus, Laurie Pajno, Giovanni Battista Panasiti, Ilenia Papadopoulos, Nikolaos G. Pellegrini, Elisabetta Pelosi, Simone Pereira, Ana M. Pereira, Mariana Pinar, Munevver Potapova, Ekaterina Priftanji, Alfred Psarros, Fotis Sackesen, Cansin Sfika, Ifigenia Suarez, Javier Thibaudon, Michel Travaglini, Alessandro Tripodi, Salvatore Verdier, Valentine Villella, Valeria Xepapadaki, Paraskevi Yazici, Duygu Matricardi, Paolo M. Dramburg, Stephanie |
| description | Background
Pollen food allergy syndrome (PFAS) is a frequently underdiagnosed disease due to diverse triggers, clinical presentations, and test results. This is especially relevant in geographic areas with a broad spectrum of pollen sensitization, such as Southern Europe.
Objectives
To elucidate similarities and differences of PFAS in nine Southern European centers and identify associated characteristics and unique markers of PFAS.
Methods
As part of the @IT.2020 Multicenter Study, 815 patients with seasonal allergic rhinitis (SAR), aged 10–60 years, were recruited in seven countries. They completed questionnaires regarding SAR, comorbidities, family history, and PFAS, and underwent skin prick testing (SPT) and serum IgE testing.
Results
Of the 815 patients, 167 (20.5%) reported PFAS reactions. Most commonly, eliciting foods were kiwi (58, 34.7%), peach (43, 25.7%), and melon (26, 15.6%). Reported reactions were mostly local (216/319, 67.7%), occurring within 5 min of contact with elicitors (209/319, 65.5%). Associated characteristics included positive IgE to at least one panallergen (profilin, PR‐10, or nsLTP) (p = 0.007), maternal PFAS (OR: 3.716, p = 0.026), and asthma (OR: 1.752, p = 0.073). Between centers, heterogeneity in prevalence (Marseille: 7.5% vs. Rome: 41.4%, p |
| doi_str_mv | 10.1111/all.14742 |
| format | Article |
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Pollen food allergy syndrome (PFAS) is a frequently underdiagnosed disease due to diverse triggers, clinical presentations, and test results. This is especially relevant in geographic areas with a broad spectrum of pollen sensitization, such as Southern Europe.
Objectives
To elucidate similarities and differences of PFAS in nine Southern European centers and identify associated characteristics and unique markers of PFAS.
Methods
As part of the @IT.2020 Multicenter Study, 815 patients with seasonal allergic rhinitis (SAR), aged 10–60 years, were recruited in seven countries. They completed questionnaires regarding SAR, comorbidities, family history, and PFAS, and underwent skin prick testing (SPT) and serum IgE testing.
Results
Of the 815 patients, 167 (20.5%) reported PFAS reactions. Most commonly, eliciting foods were kiwi (58, 34.7%), peach (43, 25.7%), and melon (26, 15.6%). Reported reactions were mostly local (216/319, 67.7%), occurring within 5 min of contact with elicitors (209/319, 65.5%). Associated characteristics included positive IgE to at least one panallergen (profilin, PR‐10, or nsLTP) (p = 0.007), maternal PFAS (OR: 3.716, p = 0.026), and asthma (OR: 1.752, p = 0.073). Between centers, heterogeneity in prevalence (Marseille: 7.5% vs. Rome: 41.4%, p < 0.001) and of clinical characteristics was apparent. Cypress played a limited role, with only 1/22 SPT mono‐sensitized patients reporting a food reaction (p < 0.073).
Conclusions
PFAS is a frequent comorbidity in Southern European SAR patients. Significant heterogeneity of clinical characteristics in PFAS patients among the centers was observed and may be related to the different pollen sensitization patterns in each geographic area. IgE to panallergen(s), maternal PFAS, and asthma could be PFAS‐associated characteristics.
In Southern Europe, there is a high heterogeneity in clinical characteristics of pollen food allergy syndrome among patients with seasonal allergic rhinitis. Patients frequently report reactions to kiwi, peach, and melon. Most patients report early localized reactions. The map was created using mapchart.net. Abbreviations: ATH, Athens; IST, Istanbul; IZM, Izmir; MAR, Marseille; MES, Messina; PFAS, pollen food allergy syndrome; POR, Porto; ROM, Rome; SAR, seasonal allergic rhinitis; TIR, Tirana; VAL, Valencia</description><identifier>ISSN: 0105-4538</identifier><identifier>EISSN: 1398-9995</identifier><identifier>DOI: 10.1111/all.14742</identifier><identifier>PMID: 33492738</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>Allergic rhinitis ; Asthma ; Food allergies ; Immunoglobulin E ; Life Sciences ; oral allergy syndrome ; panallergen ; Patients ; Pollen ; pollen food allergy syndrome ; Profilin ; seasonal allergic rhinitis ; Seasons ; Skin tests ; Southern Europe</subject><ispartof>Allergy (Copenhagen), 2021-10, Vol.76 (10), p.3041-3052</ispartof><rights>2021 The Authors. published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.</rights><rights>This article is protected by copyright. All rights reserved.</rights><rights>2021. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4222-8a9fadad2811018609e6c2039504306fba72cef16ccab905b55482a5b7ddcea73</citedby><cites>FETCH-LOGICAL-c4222-8a9fadad2811018609e6c2039504306fba72cef16ccab905b55482a5b7ddcea73</cites><orcidid>0000-0002-9303-3260 ; 0000-0003-4987-9346 ; 0000-0002-1115-9805 ; 0000-0001-6808-5942 ; 0000-0002-8135-0568 ; 0000-0001-9204-1923 ; 0000-0003-4427-6335 ; 0000-0001-5485-0324 ; 0000-0002-4448-3468 ; 0000-0002-2145-3776 ; 0000-0003-2517-3285</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fall.14742$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fall.14742$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33492738$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://amu.hal.science/hal-03654439$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Lipp, Theresa</creatorcontrib><creatorcontrib>Acar Şahin, Aydan</creatorcontrib><creatorcontrib>Aggelidis, Xenophon</creatorcontrib><creatorcontrib>Arasi, Stefania</creatorcontrib><creatorcontrib>Barbalace, Andrea</creatorcontrib><creatorcontrib>Bourgoin, Anne</creatorcontrib><creatorcontrib>Bregu, Blerina</creatorcontrib><creatorcontrib>Brighetti, Maria Antonia</creatorcontrib><creatorcontrib>Caeiro, Elsa</creatorcontrib><creatorcontrib>Caglayan Sozmen, Sule</creatorcontrib><creatorcontrib>Caminiti, Lucia</creatorcontrib><creatorcontrib>Charpin, Denis</creatorcontrib><creatorcontrib>Couto, Mariana</creatorcontrib><creatorcontrib>Delgado, Luís</creatorcontrib><creatorcontrib>Di Rienzo Businco, Andrea</creatorcontrib><creatorcontrib>Dimier, Claire</creatorcontrib><creatorcontrib>Dimou, Maria V.</creatorcontrib><creatorcontrib>Fonseca, João A.</creatorcontrib><creatorcontrib>Goksel, Ozlem</creatorcontrib><creatorcontrib>Guvensen, Aykut</creatorcontrib><creatorcontrib>Hernandez, Dolores</creatorcontrib><creatorcontrib>Hoffmann, Tara Maria</creatorcontrib><creatorcontrib>Jang, Dah Tay</creatorcontrib><creatorcontrib>Kalpaklioglu, Fusun</creatorcontrib><creatorcontrib>Lame, Blerta</creatorcontrib><creatorcontrib>Llusar, Ruth</creatorcontrib><creatorcontrib>Makris, Michael P.</creatorcontrib><creatorcontrib>Mazon, Angel</creatorcontrib><creatorcontrib>Mesonjesi, Eris</creatorcontrib><creatorcontrib>Nieto, Antonio</creatorcontrib><creatorcontrib>Öztürk, Ayse</creatorcontrib><creatorcontrib>Pahus, Laurie</creatorcontrib><creatorcontrib>Pajno, Giovanni Battista</creatorcontrib><creatorcontrib>Panasiti, Ilenia</creatorcontrib><creatorcontrib>Papadopoulos, Nikolaos G.</creatorcontrib><creatorcontrib>Pellegrini, Elisabetta</creatorcontrib><creatorcontrib>Pelosi, Simone</creatorcontrib><creatorcontrib>Pereira, Ana M.</creatorcontrib><creatorcontrib>Pereira, Mariana</creatorcontrib><creatorcontrib>Pinar, Munevver</creatorcontrib><creatorcontrib>Potapova, Ekaterina</creatorcontrib><creatorcontrib>Priftanji, Alfred</creatorcontrib><creatorcontrib>Psarros, Fotis</creatorcontrib><creatorcontrib>Sackesen, Cansin</creatorcontrib><creatorcontrib>Sfika, Ifigenia</creatorcontrib><creatorcontrib>Suarez, Javier</creatorcontrib><creatorcontrib>Thibaudon, Michel</creatorcontrib><creatorcontrib>Travaglini, Alessandro</creatorcontrib><creatorcontrib>Tripodi, Salvatore</creatorcontrib><creatorcontrib>Verdier, Valentine</creatorcontrib><creatorcontrib>Villella, Valeria</creatorcontrib><creatorcontrib>Xepapadaki, Paraskevi</creatorcontrib><creatorcontrib>Yazici, Duygu</creatorcontrib><creatorcontrib>Matricardi, Paolo M.</creatorcontrib><creatorcontrib>Dramburg, Stephanie</creatorcontrib><title>Heterogeneity of pollen food allergy syndrome in seven Southern European countries: The @IT.2020 multicenter study</title><title>Allergy (Copenhagen)</title><addtitle>Allergy</addtitle><description>Background
Pollen food allergy syndrome (PFAS) is a frequently underdiagnosed disease due to diverse triggers, clinical presentations, and test results. This is especially relevant in geographic areas with a broad spectrum of pollen sensitization, such as Southern Europe.
Objectives
To elucidate similarities and differences of PFAS in nine Southern European centers and identify associated characteristics and unique markers of PFAS.
Methods
As part of the @IT.2020 Multicenter Study, 815 patients with seasonal allergic rhinitis (SAR), aged 10–60 years, were recruited in seven countries. They completed questionnaires regarding SAR, comorbidities, family history, and PFAS, and underwent skin prick testing (SPT) and serum IgE testing.
Results
Of the 815 patients, 167 (20.5%) reported PFAS reactions. Most commonly, eliciting foods were kiwi (58, 34.7%), peach (43, 25.7%), and melon (26, 15.6%). Reported reactions were mostly local (216/319, 67.7%), occurring within 5 min of contact with elicitors (209/319, 65.5%). Associated characteristics included positive IgE to at least one panallergen (profilin, PR‐10, or nsLTP) (p = 0.007), maternal PFAS (OR: 3.716, p = 0.026), and asthma (OR: 1.752, p = 0.073). Between centers, heterogeneity in prevalence (Marseille: 7.5% vs. Rome: 41.4%, p < 0.001) and of clinical characteristics was apparent. Cypress played a limited role, with only 1/22 SPT mono‐sensitized patients reporting a food reaction (p < 0.073).
Conclusions
PFAS is a frequent comorbidity in Southern European SAR patients. Significant heterogeneity of clinical characteristics in PFAS patients among the centers was observed and may be related to the different pollen sensitization patterns in each geographic area. IgE to panallergen(s), maternal PFAS, and asthma could be PFAS‐associated characteristics.
In Southern Europe, there is a high heterogeneity in clinical characteristics of pollen food allergy syndrome among patients with seasonal allergic rhinitis. Patients frequently report reactions to kiwi, peach, and melon. Most patients report early localized reactions. The map was created using mapchart.net. Abbreviations: ATH, Athens; IST, Istanbul; IZM, Izmir; MAR, Marseille; MES, Messina; PFAS, pollen food allergy syndrome; POR, Porto; ROM, Rome; SAR, seasonal allergic rhinitis; TIR, Tirana; VAL, Valencia</description><subject>Allergic rhinitis</subject><subject>Asthma</subject><subject>Food allergies</subject><subject>Immunoglobulin E</subject><subject>Life Sciences</subject><subject>oral allergy syndrome</subject><subject>panallergen</subject><subject>Patients</subject><subject>Pollen</subject><subject>pollen food allergy syndrome</subject><subject>Profilin</subject><subject>seasonal allergic rhinitis</subject><subject>Seasons</subject><subject>Skin tests</subject><subject>Southern 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study</title><author>Lipp, Theresa ; Acar Şahin, Aydan ; Aggelidis, Xenophon ; Arasi, Stefania ; Barbalace, Andrea ; Bourgoin, Anne ; Bregu, Blerina ; Brighetti, Maria Antonia ; Caeiro, Elsa ; Caglayan Sozmen, Sule ; Caminiti, Lucia ; Charpin, Denis ; Couto, Mariana ; Delgado, Luís ; Di Rienzo Businco, Andrea ; Dimier, Claire ; Dimou, Maria V. ; Fonseca, João A. ; Goksel, Ozlem ; Guvensen, Aykut ; Hernandez, Dolores ; Hoffmann, Tara Maria ; Jang, Dah Tay ; Kalpaklioglu, Fusun ; Lame, Blerta ; Llusar, Ruth ; Makris, Michael P. ; Mazon, Angel ; Mesonjesi, Eris ; Nieto, Antonio ; Öztürk, Ayse ; Pahus, Laurie ; Pajno, Giovanni Battista ; Panasiti, Ilenia ; Papadopoulos, Nikolaos G. ; Pellegrini, Elisabetta ; Pelosi, Simone ; Pereira, Ana M. ; Pereira, Mariana ; Pinar, Munevver ; Potapova, Ekaterina ; Priftanji, Alfred ; Psarros, Fotis ; Sackesen, Cansin ; Sfika, Ifigenia ; Suarez, Javier ; Thibaudon, Michel ; Travaglini, Alessandro ; Tripodi, Salvatore ; Verdier, Valentine ; Villella, Valeria ; Xepapadaki, Paraskevi ; Yazici, Duygu ; Matricardi, Paolo M. ; Dramburg, Stephanie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4222-8a9fadad2811018609e6c2039504306fba72cef16ccab905b55482a5b7ddcea73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Allergic rhinitis</topic><topic>Asthma</topic><topic>Food allergies</topic><topic>Immunoglobulin E</topic><topic>Life Sciences</topic><topic>oral allergy syndrome</topic><topic>panallergen</topic><topic>Patients</topic><topic>Pollen</topic><topic>pollen food allergy syndrome</topic><topic>Profilin</topic><topic>seasonal allergic rhinitis</topic><topic>Seasons</topic><topic>Skin tests</topic><topic>Southern Europe</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lipp, Theresa</creatorcontrib><creatorcontrib>Acar Şahin, Aydan</creatorcontrib><creatorcontrib>Aggelidis, Xenophon</creatorcontrib><creatorcontrib>Arasi, Stefania</creatorcontrib><creatorcontrib>Barbalace, Andrea</creatorcontrib><creatorcontrib>Bourgoin, Anne</creatorcontrib><creatorcontrib>Bregu, Blerina</creatorcontrib><creatorcontrib>Brighetti, Maria Antonia</creatorcontrib><creatorcontrib>Caeiro, Elsa</creatorcontrib><creatorcontrib>Caglayan Sozmen, Sule</creatorcontrib><creatorcontrib>Caminiti, Lucia</creatorcontrib><creatorcontrib>Charpin, Denis</creatorcontrib><creatorcontrib>Couto, Mariana</creatorcontrib><creatorcontrib>Delgado, Luís</creatorcontrib><creatorcontrib>Di Rienzo Businco, Andrea</creatorcontrib><creatorcontrib>Dimier, Claire</creatorcontrib><creatorcontrib>Dimou, Maria V.</creatorcontrib><creatorcontrib>Fonseca, João A.</creatorcontrib><creatorcontrib>Goksel, Ozlem</creatorcontrib><creatorcontrib>Guvensen, Aykut</creatorcontrib><creatorcontrib>Hernandez, Dolores</creatorcontrib><creatorcontrib>Hoffmann, Tara Maria</creatorcontrib><creatorcontrib>Jang, Dah Tay</creatorcontrib><creatorcontrib>Kalpaklioglu, Fusun</creatorcontrib><creatorcontrib>Lame, Blerta</creatorcontrib><creatorcontrib>Llusar, Ruth</creatorcontrib><creatorcontrib>Makris, Michael P.</creatorcontrib><creatorcontrib>Mazon, Angel</creatorcontrib><creatorcontrib>Mesonjesi, Eris</creatorcontrib><creatorcontrib>Nieto, Antonio</creatorcontrib><creatorcontrib>Öztürk, Ayse</creatorcontrib><creatorcontrib>Pahus, Laurie</creatorcontrib><creatorcontrib>Pajno, Giovanni Battista</creatorcontrib><creatorcontrib>Panasiti, Ilenia</creatorcontrib><creatorcontrib>Papadopoulos, Nikolaos G.</creatorcontrib><creatorcontrib>Pellegrini, Elisabetta</creatorcontrib><creatorcontrib>Pelosi, Simone</creatorcontrib><creatorcontrib>Pereira, Ana M.</creatorcontrib><creatorcontrib>Pereira, Mariana</creatorcontrib><creatorcontrib>Pinar, Munevver</creatorcontrib><creatorcontrib>Potapova, Ekaterina</creatorcontrib><creatorcontrib>Priftanji, Alfred</creatorcontrib><creatorcontrib>Psarros, Fotis</creatorcontrib><creatorcontrib>Sackesen, Cansin</creatorcontrib><creatorcontrib>Sfika, Ifigenia</creatorcontrib><creatorcontrib>Suarez, Javier</creatorcontrib><creatorcontrib>Thibaudon, Michel</creatorcontrib><creatorcontrib>Travaglini, Alessandro</creatorcontrib><creatorcontrib>Tripodi, Salvatore</creatorcontrib><creatorcontrib>Verdier, Valentine</creatorcontrib><creatorcontrib>Villella, Valeria</creatorcontrib><creatorcontrib>Xepapadaki, Paraskevi</creatorcontrib><creatorcontrib>Yazici, Duygu</creatorcontrib><creatorcontrib>Matricardi, Paolo M.</creatorcontrib><creatorcontrib>Dramburg, Stephanie</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library Free Content</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Allergy (Copenhagen)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lipp, Theresa</au><au>Acar Şahin, Aydan</au><au>Aggelidis, Xenophon</au><au>Arasi, Stefania</au><au>Barbalace, Andrea</au><au>Bourgoin, Anne</au><au>Bregu, Blerina</au><au>Brighetti, Maria Antonia</au><au>Caeiro, Elsa</au><au>Caglayan Sozmen, Sule</au><au>Caminiti, Lucia</au><au>Charpin, Denis</au><au>Couto, Mariana</au><au>Delgado, Luís</au><au>Di Rienzo Businco, Andrea</au><au>Dimier, Claire</au><au>Dimou, Maria V.</au><au>Fonseca, João A.</au><au>Goksel, Ozlem</au><au>Guvensen, Aykut</au><au>Hernandez, Dolores</au><au>Hoffmann, Tara Maria</au><au>Jang, Dah Tay</au><au>Kalpaklioglu, Fusun</au><au>Lame, Blerta</au><au>Llusar, Ruth</au><au>Makris, Michael P.</au><au>Mazon, Angel</au><au>Mesonjesi, Eris</au><au>Nieto, Antonio</au><au>Öztürk, Ayse</au><au>Pahus, Laurie</au><au>Pajno, Giovanni Battista</au><au>Panasiti, Ilenia</au><au>Papadopoulos, Nikolaos G.</au><au>Pellegrini, Elisabetta</au><au>Pelosi, Simone</au><au>Pereira, Ana M.</au><au>Pereira, Mariana</au><au>Pinar, Munevver</au><au>Potapova, Ekaterina</au><au>Priftanji, Alfred</au><au>Psarros, Fotis</au><au>Sackesen, Cansin</au><au>Sfika, Ifigenia</au><au>Suarez, Javier</au><au>Thibaudon, Michel</au><au>Travaglini, Alessandro</au><au>Tripodi, Salvatore</au><au>Verdier, Valentine</au><au>Villella, Valeria</au><au>Xepapadaki, Paraskevi</au><au>Yazici, Duygu</au><au>Matricardi, Paolo M.</au><au>Dramburg, Stephanie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heterogeneity of pollen food allergy syndrome in seven Southern European countries: The @IT.2020 multicenter study</atitle><jtitle>Allergy (Copenhagen)</jtitle><addtitle>Allergy</addtitle><date>2021-10</date><risdate>2021</risdate><volume>76</volume><issue>10</issue><spage>3041</spage><epage>3052</epage><pages>3041-3052</pages><issn>0105-4538</issn><eissn>1398-9995</eissn><abstract>Background
Pollen food allergy syndrome (PFAS) is a frequently underdiagnosed disease due to diverse triggers, clinical presentations, and test results. This is especially relevant in geographic areas with a broad spectrum of pollen sensitization, such as Southern Europe.
Objectives
To elucidate similarities and differences of PFAS in nine Southern European centers and identify associated characteristics and unique markers of PFAS.
Methods
As part of the @IT.2020 Multicenter Study, 815 patients with seasonal allergic rhinitis (SAR), aged 10–60 years, were recruited in seven countries. They completed questionnaires regarding SAR, comorbidities, family history, and PFAS, and underwent skin prick testing (SPT) and serum IgE testing.
Results
Of the 815 patients, 167 (20.5%) reported PFAS reactions. Most commonly, eliciting foods were kiwi (58, 34.7%), peach (43, 25.7%), and melon (26, 15.6%). Reported reactions were mostly local (216/319, 67.7%), occurring within 5 min of contact with elicitors (209/319, 65.5%). Associated characteristics included positive IgE to at least one panallergen (profilin, PR‐10, or nsLTP) (p = 0.007), maternal PFAS (OR: 3.716, p = 0.026), and asthma (OR: 1.752, p = 0.073). Between centers, heterogeneity in prevalence (Marseille: 7.5% vs. Rome: 41.4%, p < 0.001) and of clinical characteristics was apparent. Cypress played a limited role, with only 1/22 SPT mono‐sensitized patients reporting a food reaction (p < 0.073).
Conclusions
PFAS is a frequent comorbidity in Southern European SAR patients. Significant heterogeneity of clinical characteristics in PFAS patients among the centers was observed and may be related to the different pollen sensitization patterns in each geographic area. IgE to panallergen(s), maternal PFAS, and asthma could be PFAS‐associated characteristics.
In Southern Europe, there is a high heterogeneity in clinical characteristics of pollen food allergy syndrome among patients with seasonal allergic rhinitis. Patients frequently report reactions to kiwi, peach, and melon. Most patients report early localized reactions. The map was created using mapchart.net. Abbreviations: ATH, Athens; IST, Istanbul; IZM, Izmir; MAR, Marseille; MES, Messina; PFAS, pollen food allergy syndrome; POR, Porto; ROM, Rome; SAR, seasonal allergic rhinitis; TIR, Tirana; VAL, Valencia</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>33492738</pmid><doi>10.1111/all.14742</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-9303-3260</orcidid><orcidid>https://orcid.org/0000-0003-4987-9346</orcidid><orcidid>https://orcid.org/0000-0002-1115-9805</orcidid><orcidid>https://orcid.org/0000-0001-6808-5942</orcidid><orcidid>https://orcid.org/0000-0002-8135-0568</orcidid><orcidid>https://orcid.org/0000-0001-9204-1923</orcidid><orcidid>https://orcid.org/0000-0003-4427-6335</orcidid><orcidid>https://orcid.org/0000-0001-5485-0324</orcidid><orcidid>https://orcid.org/0000-0002-4448-3468</orcidid><orcidid>https://orcid.org/0000-0002-2145-3776</orcidid><orcidid>https://orcid.org/0000-0003-2517-3285</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0105-4538 |
| ispartof | Allergy (Copenhagen), 2021-10, Vol.76 (10), p.3041-3052 |
| issn | 0105-4538 1398-9995 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_03654439v1 |
| source | Wiley Journals; Wiley Online Library Free Content; EZB-FREE-00999 freely available EZB journals |
| subjects | Allergic rhinitis Asthma Food allergies Immunoglobulin E Life Sciences oral allergy syndrome panallergen Patients Pollen pollen food allergy syndrome Profilin seasonal allergic rhinitis Seasons Skin tests Southern Europe |
| title | Heterogeneity of pollen food allergy syndrome in seven Southern European countries: The @IT.2020 multicenter study |
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