Lifelong Voluntary Exercise Modulates Age-Related Changes in Oxidative Stress
Abstract The hypothesis that aging and regular physical activity could influence oxidative stress has been studied by comparing antioxidant activities (superoxide dismutase (SOD), glutathione peroxidase (GPX), glutathione reductase (GR), ascorbic acid and α-Tocopherol) and malondialdehyde level (MDA...
Gespeichert in:
| Veröffentlicht in: | International journal of sports medicine 2018-01, Vol.39 (1), p.21-28 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 28 |
|---|---|
| container_issue | 1 |
| container_start_page | 21 |
| container_title | International journal of sports medicine |
| container_volume | 39 |
| creator | Bouzid, Mohamed Amine Filaire, Edith Matran, Régis Robin, Sophie Fabre, Claudine |
| description | Abstract
The hypothesis that aging and regular physical activity could influence oxidative stress has been studied by comparing antioxidant activities (superoxide dismutase (SOD), glutathione peroxidase (GPX), glutathione reductase (GR), ascorbic acid and α-Tocopherol) and malondialdehyde level (MDA) in four groups: young sedentary (n=15; age: 20.3±2.8 years; YS), young active (n=16; age: 21.4±1.9 years; YA), old sedentary (n=15; age: 65.1±3.5 years; OS) and old active (n=17; age: 67.2±4.8 years; OA). Antioxidant activities and MDA level were assessed at rest and after an incremental exercise. There was no difference in resting antioxidant activities and lipid peroxidation between YS and OS. However, resting SOD and GR activities were higher in YA compared to OA (p |
| doi_str_mv | 10.1055/s-0043-119882 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_03653091v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2003017496</sourcerecordid><originalsourceid>FETCH-LOGICAL-c497t-5da517154648bcd1121bb5e2113e997b2d2e561ac5594590387e3f9a9125ecb3</originalsourceid><addsrcrecordid>eNpt0d9L5DAQB_BwKOeq9-irFHy5A6OZ_GrncVk8PVgRVO41pO3sbqTbatOK999fS_0B4lPC8GEyky9jRyDOQBhzHrkQWnEAzDL5jc1AK-QKrd5hMwGp5NpKucf2Y3wQAjSC-s72JIJFyHDGrpdhRVVTr5O_TdXXnW__JRcv1BYhUnLdlH3lO4rJfE38lsZ7mSw2vl4PtVAnNy-h9F14puSuaynGQ7a78lWkH6_nAbv_fXG_uOLLm8s_i_mSFxrTjpvSG0jBaKuzvCgBJOS5IQmgCDHNZSnJWPCFMagNCpWlpFboEaShIlcH7NfUduMr99iG7TC1a3xwV_OlG2tCWaMEwjMM9udkH9vmqafYuW2IBVWVr6npowO0mdbGWjvQk0_0oenbeljESSHU8JsaR8UnVbRNjC2t3icA4cZIXHRjJG6KZPDHr137fEvlu37LYACnE-g2gbb08ejX_f4DssWRVA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2003017496</pqid></control><display><type>article</type><title>Lifelong Voluntary Exercise Modulates Age-Related Changes in Oxidative Stress</title><source>MEDLINE</source><source>Thieme Connect Journals</source><creator>Bouzid, Mohamed Amine ; Filaire, Edith ; Matran, Régis ; Robin, Sophie ; Fabre, Claudine</creator><creatorcontrib>Bouzid, Mohamed Amine ; Filaire, Edith ; Matran, Régis ; Robin, Sophie ; Fabre, Claudine</creatorcontrib><description>Abstract
The hypothesis that aging and regular physical activity could influence oxidative stress has been studied by comparing antioxidant activities (superoxide dismutase (SOD), glutathione peroxidase (GPX), glutathione reductase (GR), ascorbic acid and α-Tocopherol) and malondialdehyde level (MDA) in four groups: young sedentary (n=15; age: 20.3±2.8 years; YS), young active (n=16; age: 21.4±1.9 years; YA), old sedentary (n=15; age: 65.1±3.5 years; OS) and old active (n=17; age: 67.2±4.8 years; OA). Antioxidant activities and MDA level were assessed at rest and after an incremental exercise. There was no difference in resting antioxidant activities and lipid peroxidation between YS and OS. However, resting SOD and GR activities were higher in YA compared to OA (p<0.01 and p<0.05, respectively) and resting MDA level was higher in OA compared to YA (p<0.01). After exercise, a significant increase in SOD and GPX activities was observed in YS, YA and OA (p<0.01). Likewise, after exercise a significant increase of MDA level in YA, OS and OA (p<0.01) was observed. In addition, the comparison of YA to OA and YS to OA revealed similar antioxidant activities and lipid peroxidation between YS and OA, whereas antioxidant activities were higher in YA compared to OA. These data suggest that beneficial effects of regular physical activity in antioxidant defense and lipid peroxidation damage could be impaired by the aging process and that regular physical activity in older adults could maintain age-related decreases in antioxidant defense.</description><identifier>ISSN: 0172-4622</identifier><identifier>EISSN: 1439-3964</identifier><identifier>DOI: 10.1055/s-0043-119882</identifier><identifier>PMID: 29169189</identifier><language>eng</language><publisher>Stuttgart · New York: Georg Thieme Verlag KG</publisher><subject>Age ; Aged ; Aging - physiology ; alpha-Tocopherol - blood ; Antioxidants ; Ascorbic Acid - blood ; Diet ; Exercise ; Exercise - physiology ; Female ; Glutathione Peroxidase - blood ; Glutathione Reductase - blood ; Humans ; Life Sciences ; Lipid Peroxidation ; Lipids ; Male ; Malondialdehyde - blood ; Oxidative stress ; Oxidative Stress - physiology ; Physical fitness ; Physical Fitness - physiology ; Physiology&Biochemistry ; Superoxide Dismutase - blood ; Vitamin E ; Young Adult</subject><ispartof>International journal of sports medicine, 2018-01, Vol.39 (1), p.21-28</ispartof><rights>Georg Thieme Verlag KG Stuttgart · New York.</rights><rights>Copyright Georg Thieme Verlag Stuttgart Jan 2018</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c497t-5da517154648bcd1121bb5e2113e997b2d2e561ac5594590387e3f9a9125ecb3</citedby><orcidid>0000-0002-5127-7486</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0043-119882.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-0043-119882$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>230,314,776,780,881,3004,3005,27901,27902,54534,54535</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29169189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.univ-lille.fr/hal-03653091$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Bouzid, Mohamed Amine</creatorcontrib><creatorcontrib>Filaire, Edith</creatorcontrib><creatorcontrib>Matran, Régis</creatorcontrib><creatorcontrib>Robin, Sophie</creatorcontrib><creatorcontrib>Fabre, Claudine</creatorcontrib><title>Lifelong Voluntary Exercise Modulates Age-Related Changes in Oxidative Stress</title><title>International journal of sports medicine</title><addtitle>Int J Sports Med</addtitle><description>Abstract
The hypothesis that aging and regular physical activity could influence oxidative stress has been studied by comparing antioxidant activities (superoxide dismutase (SOD), glutathione peroxidase (GPX), glutathione reductase (GR), ascorbic acid and α-Tocopherol) and malondialdehyde level (MDA) in four groups: young sedentary (n=15; age: 20.3±2.8 years; YS), young active (n=16; age: 21.4±1.9 years; YA), old sedentary (n=15; age: 65.1±3.5 years; OS) and old active (n=17; age: 67.2±4.8 years; OA). Antioxidant activities and MDA level were assessed at rest and after an incremental exercise. There was no difference in resting antioxidant activities and lipid peroxidation between YS and OS. However, resting SOD and GR activities were higher in YA compared to OA (p<0.01 and p<0.05, respectively) and resting MDA level was higher in OA compared to YA (p<0.01). After exercise, a significant increase in SOD and GPX activities was observed in YS, YA and OA (p<0.01). Likewise, after exercise a significant increase of MDA level in YA, OS and OA (p<0.01) was observed. In addition, the comparison of YA to OA and YS to OA revealed similar antioxidant activities and lipid peroxidation between YS and OA, whereas antioxidant activities were higher in YA compared to OA. These data suggest that beneficial effects of regular physical activity in antioxidant defense and lipid peroxidation damage could be impaired by the aging process and that regular physical activity in older adults could maintain age-related decreases in antioxidant defense.</description><subject>Age</subject><subject>Aged</subject><subject>Aging - physiology</subject><subject>alpha-Tocopherol - blood</subject><subject>Antioxidants</subject><subject>Ascorbic Acid - blood</subject><subject>Diet</subject><subject>Exercise</subject><subject>Exercise - physiology</subject><subject>Female</subject><subject>Glutathione Peroxidase - blood</subject><subject>Glutathione Reductase - blood</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Lipid Peroxidation</subject><subject>Lipids</subject><subject>Male</subject><subject>Malondialdehyde - blood</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - physiology</subject><subject>Physical fitness</subject><subject>Physical Fitness - physiology</subject><subject>Physiology&Biochemistry</subject><subject>Superoxide Dismutase - blood</subject><subject>Vitamin E</subject><subject>Young Adult</subject><issn>0172-4622</issn><issn>1439-3964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0d9L5DAQB_BwKOeq9-irFHy5A6OZ_GrncVk8PVgRVO41pO3sbqTbatOK999fS_0B4lPC8GEyky9jRyDOQBhzHrkQWnEAzDL5jc1AK-QKrd5hMwGp5NpKucf2Y3wQAjSC-s72JIJFyHDGrpdhRVVTr5O_TdXXnW__JRcv1BYhUnLdlH3lO4rJfE38lsZ7mSw2vl4PtVAnNy-h9F14puSuaynGQ7a78lWkH6_nAbv_fXG_uOLLm8s_i_mSFxrTjpvSG0jBaKuzvCgBJOS5IQmgCDHNZSnJWPCFMagNCpWlpFboEaShIlcH7NfUduMr99iG7TC1a3xwV_OlG2tCWaMEwjMM9udkH9vmqafYuW2IBVWVr6npowO0mdbGWjvQk0_0oenbeljESSHU8JsaR8UnVbRNjC2t3icA4cZIXHRjJG6KZPDHr137fEvlu37LYACnE-g2gbb08ejX_f4DssWRVA</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Bouzid, Mohamed Amine</creator><creator>Filaire, Edith</creator><creator>Matran, Régis</creator><creator>Robin, Sophie</creator><creator>Fabre, Claudine</creator><general>Georg Thieme Verlag KG</general><general>Georg Thieme Verlag Stuttgart</general><general>Thieme Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-5127-7486</orcidid></search><sort><creationdate>20180101</creationdate><title>Lifelong Voluntary Exercise Modulates Age-Related Changes in Oxidative Stress</title><author>Bouzid, Mohamed Amine ; Filaire, Edith ; Matran, Régis ; Robin, Sophie ; Fabre, Claudine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c497t-5da517154648bcd1121bb5e2113e997b2d2e561ac5594590387e3f9a9125ecb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Age</topic><topic>Aged</topic><topic>Aging - physiology</topic><topic>alpha-Tocopherol - blood</topic><topic>Antioxidants</topic><topic>Ascorbic Acid - blood</topic><topic>Diet</topic><topic>Exercise</topic><topic>Exercise - physiology</topic><topic>Female</topic><topic>Glutathione Peroxidase - blood</topic><topic>Glutathione Reductase - blood</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Lipid Peroxidation</topic><topic>Lipids</topic><topic>Male</topic><topic>Malondialdehyde - blood</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - physiology</topic><topic>Physical fitness</topic><topic>Physical Fitness - physiology</topic><topic>Physiology&Biochemistry</topic><topic>Superoxide Dismutase - blood</topic><topic>Vitamin E</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bouzid, Mohamed Amine</creatorcontrib><creatorcontrib>Filaire, Edith</creatorcontrib><creatorcontrib>Matran, Régis</creatorcontrib><creatorcontrib>Robin, Sophie</creatorcontrib><creatorcontrib>Fabre, Claudine</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>International journal of sports medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bouzid, Mohamed Amine</au><au>Filaire, Edith</au><au>Matran, Régis</au><au>Robin, Sophie</au><au>Fabre, Claudine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lifelong Voluntary Exercise Modulates Age-Related Changes in Oxidative Stress</atitle><jtitle>International journal of sports medicine</jtitle><addtitle>Int J Sports Med</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>39</volume><issue>1</issue><spage>21</spage><epage>28</epage><pages>21-28</pages><issn>0172-4622</issn><eissn>1439-3964</eissn><abstract>Abstract
The hypothesis that aging and regular physical activity could influence oxidative stress has been studied by comparing antioxidant activities (superoxide dismutase (SOD), glutathione peroxidase (GPX), glutathione reductase (GR), ascorbic acid and α-Tocopherol) and malondialdehyde level (MDA) in four groups: young sedentary (n=15; age: 20.3±2.8 years; YS), young active (n=16; age: 21.4±1.9 years; YA), old sedentary (n=15; age: 65.1±3.5 years; OS) and old active (n=17; age: 67.2±4.8 years; OA). Antioxidant activities and MDA level were assessed at rest and after an incremental exercise. There was no difference in resting antioxidant activities and lipid peroxidation between YS and OS. However, resting SOD and GR activities were higher in YA compared to OA (p<0.01 and p<0.05, respectively) and resting MDA level was higher in OA compared to YA (p<0.01). After exercise, a significant increase in SOD and GPX activities was observed in YS, YA and OA (p<0.01). Likewise, after exercise a significant increase of MDA level in YA, OS and OA (p<0.01) was observed. In addition, the comparison of YA to OA and YS to OA revealed similar antioxidant activities and lipid peroxidation between YS and OA, whereas antioxidant activities were higher in YA compared to OA. These data suggest that beneficial effects of regular physical activity in antioxidant defense and lipid peroxidation damage could be impaired by the aging process and that regular physical activity in older adults could maintain age-related decreases in antioxidant defense.</abstract><cop>Stuttgart · New York</cop><pub>Georg Thieme Verlag KG</pub><pmid>29169189</pmid><doi>10.1055/s-0043-119882</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-5127-7486</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0172-4622 |
| ispartof | International journal of sports medicine, 2018-01, Vol.39 (1), p.21-28 |
| issn | 0172-4622 1439-3964 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_03653091v1 |
| source | MEDLINE; Thieme Connect Journals |
| subjects | Age Aged Aging - physiology alpha-Tocopherol - blood Antioxidants Ascorbic Acid - blood Diet Exercise Exercise - physiology Female Glutathione Peroxidase - blood Glutathione Reductase - blood Humans Life Sciences Lipid Peroxidation Lipids Male Malondialdehyde - blood Oxidative stress Oxidative Stress - physiology Physical fitness Physical Fitness - physiology Physiology&Biochemistry Superoxide Dismutase - blood Vitamin E Young Adult |
| title | Lifelong Voluntary Exercise Modulates Age-Related Changes in Oxidative Stress |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T16%3A24%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Lifelong%20Voluntary%20Exercise%20Modulates%20Age-Related%20Changes%20in%20Oxidative%20Stress&rft.jtitle=International%20journal%20of%20sports%20medicine&rft.au=Bouzid,%20Mohamed%20Amine&rft.date=2018-01-01&rft.volume=39&rft.issue=1&rft.spage=21&rft.epage=28&rft.pages=21-28&rft.issn=0172-4622&rft.eissn=1439-3964&rft_id=info:doi/10.1055/s-0043-119882&rft_dat=%3Cproquest_hal_p%3E2003017496%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2003017496&rft_id=info:pmid/29169189&rfr_iscdi=true |