Genotoxic risk of ethyl‐paraben could be related to telomere shortening

The ability of parabens to promote the appearance of multiple cancer hallmarks in breast epithelium cells provides grounds for regulatory review of the implication of the presence of parabens in human breast tissue. It is well documented that telomere dysfunction plays a significant role in the init...

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Veröffentlicht in:	Journal of applied toxicology 2017-06, Vol.37 (6), p.758-771
Hauptverfasser:	Finot, F., Kaddour, A., Morat, L., Mouche, I., Zaguia, N., Cuceu, C., Souverville, D., Négrault, S., Cariou, O., Essahli, A., Prigent, N., Saul, J., Paillard, F., Heidingsfelder, L., Lafouge, P., Al Jawhari, M., Hempel, W. M., El May, M., Colicchio, B., Dieterlen, A., Jeandidier, E., Sabatier, L., Clements, J., M'Kacher, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation, Metabolic Animals Bioengineering Cell Culture Techniques Cell Line, Tumor chromosomal aberrations ethyl‐paraben Humans Life Sciences Lymphocytes - drug effects Lymphocytes - pathology metabolic activation Mice Micronuclei, Chromosome-Defective - chemically induced Micronuclei, Chromosome-Defective - statistics & numerical data micronucleus Microsomes, Liver - metabolism Mutagens - toxicity Parabens - toxicity Rats, Sprague-Dawley telomere shortening Telomere Shortening - drug effects
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