Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum-to-mitochondria Ca 2+ transfer for survival

Spontaneous Ca signaling from the InsP R intracellular Ca release channel to mitochondria is essential for optimal oxidative phosphorylation (OXPHOS) and ATP production. In cells with defective OXPHOS, reductive carboxylation replaces oxidative metabolism to maintain amounts of reducing equivalents...

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Veröffentlicht in:	Science signaling 2020-07, Vol.13 (640)
Hauptverfasser:	Cardenas, Cesar, Lovy, Alenka, Silva-Pavez, Eduardo, Urra, Felix, Mizzoni, Craig, Ahumada-Castro, Ulises, Bustos, Galdo, Jaňa, Fabian, Cruz, Pablo, Farias, Paula, Mendoza, Elizabeth, Huerta, Hernan, Murgas, Paola, Hunter, Martin, Rios, Melany, Cerda, Oscar, Georgakoudi, Irene, Zakarian, Armen, Molgó, Jordi, Foskett, J Kevin
Format:	Artikel
Sprache:	eng
Schlagworte:	Life Sciences
Online-Zugang:	Volltext
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