γ-heregulin is the product of a chromosomal translocation fusing the DOC4 and HGL/NRG1 genes in the MDA-MB-175 breast cancer cell line

gamma-heregulin is a recently described novel isoform of the heregulin/neuregulin class of EGF-like ligands that bind to and activate receptors of the ErbB family. Deregulated signaling through the heregulin-ErbB pathway is thought to be implicated in the development of a subset of human breast canc...

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Veröffentlicht in:	Oncogene 1999-10, Vol.18 (41), p.5718-5721
Hauptverfasser:	WANG, X.-Z, JOLICOEUR, E. M, CONTE, N, CHAFFANET, M, YUHONG ZHANG, MOZZICONACCI, M.-J, FEINER, H, BIRNBAUM, D, PEBUSQUE, M.-J, RON, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Autocrine signalling Biological and medical sciences Breast cancer Breast carcinoma Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer Carcinoma - genetics Carcinoma - pathology Carrier Proteins - genetics Cell culture Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes chromosome 11 chromosome 8 Chromosome translocations Chromosomes Chromosomes, Human, Pair 11 - genetics Chromosomes, Human, Pair 11 - ultrastructure Chromosomes, Human, Pair 8 - genetics Chromosomes, Human, Pair 8 - ultrastructure DOC4 gene DOC4 protein ErbB protein Female Fundamental and applied biological sciences. Psychology Fusion protein g-heregulin Gene Expression Regulation, Neoplastic Genes Heregulin HGL gene Humans In Situ Hybridization, Fluorescence Isoforms Life Sciences Membrane Proteins Molecular and cellular biology N-Terminus Neuregulin Neuregulin 1 Neuregulin-1 - genetics NRG1 gene Nuclear Proteins - genetics Oncogene Proteins, Fusion - genetics Receptor, ErbB-2 - physiology Signal Transduction Translocation, Genetic Tumor Cells, Cultured
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