Hypo-response of the hypothalamic-pituitary-adrenocortical axis after an ethanol challenge in prenatally stressed adolescent male rats
The period of adolescence and environmental factors, such as stress, are important in determining ethanol vulnerability in both humans and rats. Ethanol is a powerful activator of the hypothalamic‐pituitary‐adrenal (HPA) axis but attenuated responses of the HPA axis to ethanol have been described in...
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| Veröffentlicht in: | The European journal of neuroscience 2006-08, Vol.24 (4), p.1193-1200 |
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| creator | Van Waes, Vincent Enache, Mihaela Dutriez, Isabelle Lesage, Jean Morley-Fletcher, Sara Vinner, Elisabeth Lhermitte, Michel Vieau, Didier Maccari, Stefania Darnaudéry, Muriel |
| description | The period of adolescence and environmental factors, such as stress, are important in determining ethanol vulnerability in both humans and rats. Ethanol is a powerful activator of the hypothalamic‐pituitary‐adrenal (HPA) axis but attenuated responses of the HPA axis to ethanol have been described in populations with a high risk of ethanol abuse. In rats, prenatal stress leads to prolonged stress‐induced corticosterone secretion and increases the vulnerability to drugs of abuse, such as amphetamine and nicotine in adulthood and 3,4‐methylenedioxymethamphetamine in adolescent rats. The aim of the present study was to assess the impact of a prenatal stress on HPA axis responsiveness to a moderate dose of ethanol (1.5 g/kg i.p.) in adolescent male rats (28 days old). The parameters evaluated were plasma adrenocorticotropic hormone, plasma corticosterone and mRNA expression of HPA axis central markers (mineralocorticoid receptor, glucocorticoid receptor, corticotropin‐releasing hormone and pro‐opiomelanocortin). Contrary to prior expectations, our results demonstrate that prenatal stress blunts the HPA axis responsiveness to a moderate dose of ethanol in adolescent rats in spite of similar blood ethanol levels. These data suggest that prenatal stress may have the opposite effect on the response to stress depending on the attributes of the stressor stimulus. They thus raise questions about the possible impact of prenatal stress on the further development of ethanol vulnerability. |
| doi_str_mv | 10.1111/j.1460-9568.2006.04973.x |
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Ethanol is a powerful activator of the hypothalamic‐pituitary‐adrenal (HPA) axis but attenuated responses of the HPA axis to ethanol have been described in populations with a high risk of ethanol abuse. In rats, prenatal stress leads to prolonged stress‐induced corticosterone secretion and increases the vulnerability to drugs of abuse, such as amphetamine and nicotine in adulthood and 3,4‐methylenedioxymethamphetamine in adolescent rats. The aim of the present study was to assess the impact of a prenatal stress on HPA axis responsiveness to a moderate dose of ethanol (1.5 g/kg i.p.) in adolescent male rats (28 days old). The parameters evaluated were plasma adrenocorticotropic hormone, plasma corticosterone and mRNA expression of HPA axis central markers (mineralocorticoid receptor, glucocorticoid receptor, corticotropin‐releasing hormone and pro‐opiomelanocortin). Contrary to prior expectations, our results demonstrate that prenatal stress blunts the HPA axis responsiveness to a moderate dose of ethanol in adolescent rats in spite of similar blood ethanol levels. These data suggest that prenatal stress may have the opposite effect on the response to stress depending on the attributes of the stressor stimulus. They thus raise questions about the possible impact of prenatal stress on the further development of ethanol vulnerability.</description><identifier>ISSN: 0953-816X</identifier><identifier>EISSN: 1460-9568</identifier><identifier>DOI: 10.1111/j.1460-9568.2006.04973.x</identifier><identifier>PMID: 16925589</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>adrenocorticotropic hormone ; Adrenocorticotropic Hormone - blood ; alcohol ; Animals ; Body Weight ; corticosterone ; Corticosterone - blood ; corticotropin-releasing hormone ; Corticotropin-Releasing Hormone - genetics ; Corticotropin-Releasing Hormone - metabolism ; Dentate Gyrus - cytology ; Dentate Gyrus - metabolism ; Ethanol - pharmacology ; Female ; Humans ; Hypothalamo-Hypophyseal System - drug effects ; Hypothalamo-Hypophyseal System - physiology ; Life Sciences ; Male ; maternal stress ; Neurons and Cognition ; Paraventricular Hypothalamic Nucleus - cytology ; Paraventricular Hypothalamic Nucleus - metabolism ; Pituitary Gland - cytology ; Pituitary Gland - metabolism ; Pituitary-Adrenal System - drug effects ; Pituitary-Adrenal System - physiology ; Pregnancy ; Pro-Opiomelanocortin - genetics ; Pro-Opiomelanocortin - metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Glucocorticoid - genetics ; Receptors, Glucocorticoid - metabolism ; Receptors, Mineralocorticoid - genetics ; Receptors, Mineralocorticoid - metabolism ; RNA, Messenger - metabolism ; Stress, Psychological</subject><ispartof>The European journal of neuroscience, 2006-08, Vol.24 (4), p.1193-1200</ispartof><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4703-f12e7d4631eaea97f2509d6aa7ce15f125b8d298768a5a2ec3ac17b097f667e53</citedby><cites>FETCH-LOGICAL-c4703-f12e7d4631eaea97f2509d6aa7ce15f125b8d298768a5a2ec3ac17b097f667e53</cites><orcidid>0000-0003-0209-3880</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1460-9568.2006.04973.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1460-9568.2006.04973.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,778,782,883,1414,27911,27912,45561,45562</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16925589$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://univ-fcomte.hal.science/hal-03626414$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Van Waes, Vincent</creatorcontrib><creatorcontrib>Enache, Mihaela</creatorcontrib><creatorcontrib>Dutriez, Isabelle</creatorcontrib><creatorcontrib>Lesage, Jean</creatorcontrib><creatorcontrib>Morley-Fletcher, Sara</creatorcontrib><creatorcontrib>Vinner, Elisabeth</creatorcontrib><creatorcontrib>Lhermitte, Michel</creatorcontrib><creatorcontrib>Vieau, Didier</creatorcontrib><creatorcontrib>Maccari, Stefania</creatorcontrib><creatorcontrib>Darnaudéry, Muriel</creatorcontrib><title>Hypo-response of the hypothalamic-pituitary-adrenocortical axis after an ethanol challenge in prenatally stressed adolescent male rats</title><title>The European journal of neuroscience</title><addtitle>Eur J Neurosci</addtitle><description>The period of adolescence and environmental factors, such as stress, are important in determining ethanol vulnerability in both humans and rats. Ethanol is a powerful activator of the hypothalamic‐pituitary‐adrenal (HPA) axis but attenuated responses of the HPA axis to ethanol have been described in populations with a high risk of ethanol abuse. In rats, prenatal stress leads to prolonged stress‐induced corticosterone secretion and increases the vulnerability to drugs of abuse, such as amphetamine and nicotine in adulthood and 3,4‐methylenedioxymethamphetamine in adolescent rats. The aim of the present study was to assess the impact of a prenatal stress on HPA axis responsiveness to a moderate dose of ethanol (1.5 g/kg i.p.) in adolescent male rats (28 days old). The parameters evaluated were plasma adrenocorticotropic hormone, plasma corticosterone and mRNA expression of HPA axis central markers (mineralocorticoid receptor, glucocorticoid receptor, corticotropin‐releasing hormone and pro‐opiomelanocortin). Contrary to prior expectations, our results demonstrate that prenatal stress blunts the HPA axis responsiveness to a moderate dose of ethanol in adolescent rats in spite of similar blood ethanol levels. These data suggest that prenatal stress may have the opposite effect on the response to stress depending on the attributes of the stressor stimulus. They thus raise questions about the possible impact of prenatal stress on the further development of ethanol vulnerability.</description><subject>adrenocorticotropic hormone</subject><subject>Adrenocorticotropic Hormone - blood</subject><subject>alcohol</subject><subject>Animals</subject><subject>Body Weight</subject><subject>corticosterone</subject><subject>Corticosterone - blood</subject><subject>corticotropin-releasing hormone</subject><subject>Corticotropin-Releasing Hormone - genetics</subject><subject>Corticotropin-Releasing Hormone - metabolism</subject><subject>Dentate Gyrus - cytology</subject><subject>Dentate Gyrus - metabolism</subject><subject>Ethanol - pharmacology</subject><subject>Female</subject><subject>Humans</subject><subject>Hypothalamo-Hypophyseal System - drug effects</subject><subject>Hypothalamo-Hypophyseal System - physiology</subject><subject>Life Sciences</subject><subject>Male</subject><subject>maternal stress</subject><subject>Neurons and Cognition</subject><subject>Paraventricular Hypothalamic Nucleus - cytology</subject><subject>Paraventricular Hypothalamic Nucleus - metabolism</subject><subject>Pituitary Gland - cytology</subject><subject>Pituitary Gland - metabolism</subject><subject>Pituitary-Adrenal System - drug effects</subject><subject>Pituitary-Adrenal System - physiology</subject><subject>Pregnancy</subject><subject>Pro-Opiomelanocortin - genetics</subject><subject>Pro-Opiomelanocortin - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Glucocorticoid - genetics</subject><subject>Receptors, Glucocorticoid - metabolism</subject><subject>Receptors, Mineralocorticoid - genetics</subject><subject>Receptors, Mineralocorticoid - metabolism</subject><subject>RNA, Messenger - metabolism</subject><subject>Stress, Psychological</subject><issn>0953-816X</issn><issn>1460-9568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcGO0zAQhi0EYkvhFZBPSBxS7CS24wOH1WrZsqqKVixib9Y0mVCXNM7aLrQvwHPj0KocwRdbM_8381s_IZSzGU_n3WbGS8kyLWQ1yxmTM1ZqVcz2T8jk3HhKJkyLIqu4fLggL0LYMMYqWYrn5IJLnQtR6Qn5NT8MLvMYBtcHpK6lcY10nYpxDR1sbZ0NNu5sBH_IoPHYu9r5aGvoKOxtoNBG9BR6ignoXUfrxHXYf0NqezokAGIqHGiIaUvAhkLjOgw19pFuoUPqIYaX5FkLXcBXp3tKvny4vr-aZ4tPNx-vLhdZXSpWZC3PUTWlLDgCglZtLphuJICqkYvUFauqyXWlZAUCcqwLqLlasaSUUqEopuTtcW4yaQZvt-lbxoE188uFGWuskLksefmDJ-2bo3bw7nGHIZqtTba7Dnp0u2BkpTTj5b-FXAvORPI_JdVRWHsXgsf2bIEzMwZrNmbMz4z5mTFY8ydYs0_o69OO3WqLzV_wlGQSvD8KftoOD_892FzfLsdX4rMjb0PE_ZkH_91IVShhvi5vzP3D5-XdXN-au-I3jq3DqQ</recordid><startdate>200608</startdate><enddate>200608</enddate><creator>Van Waes, Vincent</creator><creator>Enache, Mihaela</creator><creator>Dutriez, Isabelle</creator><creator>Lesage, Jean</creator><creator>Morley-Fletcher, Sara</creator><creator>Vinner, Elisabeth</creator><creator>Lhermitte, Michel</creator><creator>Vieau, Didier</creator><creator>Maccari, Stefania</creator><creator>Darnaudéry, Muriel</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0003-0209-3880</orcidid></search><sort><creationdate>200608</creationdate><title>Hypo-response of the hypothalamic-pituitary-adrenocortical axis after an ethanol challenge in prenatally stressed adolescent male rats</title><author>Van Waes, Vincent ; Enache, Mihaela ; Dutriez, Isabelle ; Lesage, Jean ; Morley-Fletcher, Sara ; Vinner, Elisabeth ; Lhermitte, Michel ; Vieau, Didier ; Maccari, Stefania ; Darnaudéry, Muriel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4703-f12e7d4631eaea97f2509d6aa7ce15f125b8d298768a5a2ec3ac17b097f667e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>adrenocorticotropic hormone</topic><topic>Adrenocorticotropic Hormone - blood</topic><topic>alcohol</topic><topic>Animals</topic><topic>Body Weight</topic><topic>corticosterone</topic><topic>Corticosterone - blood</topic><topic>corticotropin-releasing hormone</topic><topic>Corticotropin-Releasing Hormone - genetics</topic><topic>Corticotropin-Releasing Hormone - metabolism</topic><topic>Dentate Gyrus - cytology</topic><topic>Dentate Gyrus - metabolism</topic><topic>Ethanol - pharmacology</topic><topic>Female</topic><topic>Humans</topic><topic>Hypothalamo-Hypophyseal System - drug effects</topic><topic>Hypothalamo-Hypophyseal System - physiology</topic><topic>Life Sciences</topic><topic>Male</topic><topic>maternal stress</topic><topic>Neurons and Cognition</topic><topic>Paraventricular Hypothalamic Nucleus - cytology</topic><topic>Paraventricular Hypothalamic Nucleus - metabolism</topic><topic>Pituitary Gland - cytology</topic><topic>Pituitary Gland - metabolism</topic><topic>Pituitary-Adrenal System - drug effects</topic><topic>Pituitary-Adrenal System - physiology</topic><topic>Pregnancy</topic><topic>Pro-Opiomelanocortin - genetics</topic><topic>Pro-Opiomelanocortin - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Glucocorticoid - genetics</topic><topic>Receptors, Glucocorticoid - metabolism</topic><topic>Receptors, Mineralocorticoid - genetics</topic><topic>Receptors, Mineralocorticoid - metabolism</topic><topic>RNA, Messenger - metabolism</topic><topic>Stress, Psychological</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van Waes, Vincent</creatorcontrib><creatorcontrib>Enache, Mihaela</creatorcontrib><creatorcontrib>Dutriez, Isabelle</creatorcontrib><creatorcontrib>Lesage, Jean</creatorcontrib><creatorcontrib>Morley-Fletcher, Sara</creatorcontrib><creatorcontrib>Vinner, Elisabeth</creatorcontrib><creatorcontrib>Lhermitte, Michel</creatorcontrib><creatorcontrib>Vieau, Didier</creatorcontrib><creatorcontrib>Maccari, Stefania</creatorcontrib><creatorcontrib>Darnaudéry, Muriel</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>The European journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van Waes, Vincent</au><au>Enache, Mihaela</au><au>Dutriez, Isabelle</au><au>Lesage, Jean</au><au>Morley-Fletcher, Sara</au><au>Vinner, Elisabeth</au><au>Lhermitte, Michel</au><au>Vieau, Didier</au><au>Maccari, Stefania</au><au>Darnaudéry, Muriel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypo-response of the hypothalamic-pituitary-adrenocortical axis after an ethanol challenge in prenatally stressed adolescent male rats</atitle><jtitle>The European journal of neuroscience</jtitle><addtitle>Eur J Neurosci</addtitle><date>2006-08</date><risdate>2006</risdate><volume>24</volume><issue>4</issue><spage>1193</spage><epage>1200</epage><pages>1193-1200</pages><issn>0953-816X</issn><eissn>1460-9568</eissn><abstract>The period of adolescence and environmental factors, such as stress, are important in determining ethanol vulnerability in both humans and rats. Ethanol is a powerful activator of the hypothalamic‐pituitary‐adrenal (HPA) axis but attenuated responses of the HPA axis to ethanol have been described in populations with a high risk of ethanol abuse. In rats, prenatal stress leads to prolonged stress‐induced corticosterone secretion and increases the vulnerability to drugs of abuse, such as amphetamine and nicotine in adulthood and 3,4‐methylenedioxymethamphetamine in adolescent rats. The aim of the present study was to assess the impact of a prenatal stress on HPA axis responsiveness to a moderate dose of ethanol (1.5 g/kg i.p.) in adolescent male rats (28 days old). The parameters evaluated were plasma adrenocorticotropic hormone, plasma corticosterone and mRNA expression of HPA axis central markers (mineralocorticoid receptor, glucocorticoid receptor, corticotropin‐releasing hormone and pro‐opiomelanocortin). Contrary to prior expectations, our results demonstrate that prenatal stress blunts the HPA axis responsiveness to a moderate dose of ethanol in adolescent rats in spite of similar blood ethanol levels. These data suggest that prenatal stress may have the opposite effect on the response to stress depending on the attributes of the stressor stimulus. They thus raise questions about the possible impact of prenatal stress on the further development of ethanol vulnerability.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16925589</pmid><doi>10.1111/j.1460-9568.2006.04973.x</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-0209-3880</orcidid></addata></record> |
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| subjects | adrenocorticotropic hormone Adrenocorticotropic Hormone - blood alcohol Animals Body Weight corticosterone Corticosterone - blood corticotropin-releasing hormone Corticotropin-Releasing Hormone - genetics Corticotropin-Releasing Hormone - metabolism Dentate Gyrus - cytology Dentate Gyrus - metabolism Ethanol - pharmacology Female Humans Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - physiology Life Sciences Male maternal stress Neurons and Cognition Paraventricular Hypothalamic Nucleus - cytology Paraventricular Hypothalamic Nucleus - metabolism Pituitary Gland - cytology Pituitary Gland - metabolism Pituitary-Adrenal System - drug effects Pituitary-Adrenal System - physiology Pregnancy Pro-Opiomelanocortin - genetics Pro-Opiomelanocortin - metabolism Rats Rats, Sprague-Dawley Receptors, Glucocorticoid - genetics Receptors, Glucocorticoid - metabolism Receptors, Mineralocorticoid - genetics Receptors, Mineralocorticoid - metabolism RNA, Messenger - metabolism Stress, Psychological |
| title | Hypo-response of the hypothalamic-pituitary-adrenocortical axis after an ethanol challenge in prenatally stressed adolescent male rats |
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