Identification of new classes among acute myelogenous leukaemias with normal karyotype using gene expression profiling

Conventional cytogenetic analysis currently stratifies acute myelogenous leukaemia (AML) into prognostically relevant groups. However, approximately 50% of adult AMLs have normal cytogenetics (NC-AMLs), and represent a heterogeneous and poorly understood group. We analysed gene expression in 55 AML...

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Veröffentlicht in:	Oncogene 2004-12, Vol.23 (58), p.9381-9391
Hauptverfasser:	Vey, Norbert, Mozziconacci, Marie-Joëlle, Groulet-Martinec, Agnès, Debono, Stéphane, Finetti, Pascal, Carbuccia, Nadine, Beillard, Emmanuel, Devilard, Elizabeth, Arnoulet, Christine, Coso, Diane, Sainty, Danielle, Xerri, Luc, Stoppa, Anne-Marie, Lafage-Pochitaloff, Marina, Nguyen, Catherine, Houlgatte, Rémi, Blaise, Didier, Maraninchi, Dominique, Birg, Françoise, Birnbaum, Daniel, Bertucci, François
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biological and medical sciences Cancer Cell Biology Cell lines Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chemotherapy Clonal deletion Cytogenetics DNA microarrays DNA-Binding Proteins - genetics Drug resistance fms-Like Tyrosine Kinase 3 Fundamental and applied biological sciences. Psychology Gene deletion Gene Duplication Gene expression Gene Expression Profiling Hematologic and hematopoietic diseases Histone-Lysine N-Methyltransferase Human Genetics Humans Internal Medicine Karyotypes Karyotyping Leukemia Leukemia, Myeloid, Acute - classification Leukemia, Myeloid, Acute - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Life Sciences Medical sciences Medicine Medicine & Public Health MLL protein Molecular and cellular biology Myeloid-Lymphoid Leukemia Protein Oncology original-paper Patients Prognosis Protein transport Proto-Oncogene Proteins - genetics Proto-Oncogenes - genetics Receptor Protein-Tyrosine Kinases - genetics Transcription Transcription Factors - genetics Trisomy
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