Metabolic-Pathway-Based Subtyping of Triple-Negative Breast Cancer Reveals Potential Therapeutic Targets

Triple-negative breast cancer (TNBC) remains an unmet medical challenge. We investigated metabolic dysregulation in TNBCs by using our multi-omics database (n = 465, the largest to date). TNBC samples were classified into three heterogeneous metabolic-pathway-based subtypes (MPSs) with distinct meta...

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Veröffentlicht in:	Cell metabolism 2021-01, Vol.33 (1), p.51-64.e9
Hauptverfasser:	Gong, Yue, Ji, Peng, Yang, Yun-Song, Xie, Shao, Yu, Tian-Jian, Xiao, Yi, Jin, Ming-Liang, Ma, Ding, Guo, Lin-Wei, Pei, Yu-Chen, Chai, Wen-Jun, Li, Da-Qiang, Bai, Fan, Bertucci, François, Hu, Xin, Jiang, Yi-Zhou, Shao, Zhi-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer Female glycolysis heterogeneity Humans Immunotherapy Life Sciences Mammary Neoplasms, Experimental - metabolism Mammary Neoplasms, Experimental - therapy metabolic inhibitor metabolic pathway metabolism Mice Mice, Inbred BALB C Middle Aged subtype survival Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - therapy triple-negative breast cancer Tumor Cells, Cultured
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