Endocrine-disrupting chemicals and behaviour: A high risk to take?
Early life exposure to endocrine-disrupting chemicals (EDCs) is considered a potential risk factor for aberrant brain development and the emergence of behavioral deficits. The purpose of this review is to summarize the toxic effects of bisphenol-A (BPA) and phthalate exposure during pre-, -post- or...
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| Veröffentlicht in: | Baillière's best practice & research. Clinical endocrinology & metabolism 2021-09, Vol.35 (5), p.101517, Article 101517 |
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| container_title | Baillière's best practice & research. Clinical endocrinology & metabolism |
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| creator | Bakoyiannis, Ioannis Kitraki, Efthymia Stamatakis, Antonios |
| description | Early life exposure to endocrine-disrupting chemicals (EDCs) is considered a potential risk factor for aberrant brain development and the emergence of behavioral deficits. The purpose of this review is to summarize the toxic effects of bisphenol-A (BPA) and phthalate exposure during pre-, -post- or perinatal life on different types of behaviour in male and female rodents. Despite results not being always consistent, most probably due to methodological issues, it is highly probable that early life exposure to BPA or/and phthalates, affects various aspects of behaviour in the offspring. Adverse effects include: Increased levels of anxiety, altered exploratory behaviour, reduced social interaction or increased aggression and deficits in spatial or recognition learning and memory. These effects have been observed with a wide range of doses, in some cases even below the currently employed Tolerable Daily Intake dose for either BPA or phthalates. |
| doi_str_mv | 10.1016/j.beem.2021.101517 |
| format | Article |
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| ispartof | Baillière's best practice & research. Clinical endocrinology & metabolism, 2021-09, Vol.35 (5), p.101517, Article 101517 |
| issn | 1521-690X 1878-1594 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete |
| subjects | anxiety BPA endocrine disruptors Life Sciences memory phthalate social behavior |
| title | Endocrine-disrupting chemicals and behaviour: A high risk to take? |
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