Measurement of carbon ion microdosimetric distributions with ultrathin 3D silicon diodes
The commissioning of an ion beam for hadrontherapy requires the evaluation of the biologically weighted effective dose that results from the microdosimetric properties of the therapy beam. The spectra of the energy imparted at cellular and sub-cellular scales are fundamental to the determination of...
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| Veröffentlicht in: | Physics in medicine & biology 2016-06, Vol.61 (11), p.4036-4047 |
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| creator | Gómez, F Fleta, C Esteban, S Quirion, D Pellegrini, G Lozano, M Prezado, Y Dos Santos, M Guardiola, C Montarou, G Prieto-Pena, J Pardo-Montero, Juan |
| description | The commissioning of an ion beam for hadrontherapy requires the evaluation of the biologically weighted effective dose that results from the microdosimetric properties of the therapy beam. The spectra of the energy imparted at cellular and sub-cellular scales are fundamental to the determination of the biological effect of the beam. These magnitudes are related to the microdosimetric distributions of the ion beam at different points along the beam path. This work is dedicated to the measurement of microdosimetric spectra at several depths in the central axis of a 12C beam with an energy of 94.98 AMeV using a novel 3D ultrathin silicon diode detector. Data is compared with Monte Carlo calculations providing an excellent agreement (deviations are less than 2% for the most probable lineal energy value) up to the Bragg peak. The results show the feasibility to determine with high precision the lineal energy transfer spectrum of a hadrontherapy beam with these silicon devices. |
| doi_str_mv | 10.1088/0031-9155/61/11/4036 |
| format | Article |
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The spectra of the energy imparted at cellular and sub-cellular scales are fundamental to the determination of the biological effect of the beam. These magnitudes are related to the microdosimetric distributions of the ion beam at different points along the beam path. This work is dedicated to the measurement of microdosimetric spectra at several depths in the central axis of a 12C beam with an energy of 94.98 AMeV using a novel 3D ultrathin silicon diode detector. Data is compared with Monte Carlo calculations providing an excellent agreement (deviations are less than 2% for the most probable lineal energy value) up to the Bragg peak. 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Med. Biol</addtitle><description>The commissioning of an ion beam for hadrontherapy requires the evaluation of the biologically weighted effective dose that results from the microdosimetric properties of the therapy beam. The spectra of the energy imparted at cellular and sub-cellular scales are fundamental to the determination of the biological effect of the beam. These magnitudes are related to the microdosimetric distributions of the ion beam at different points along the beam path. This work is dedicated to the measurement of microdosimetric spectra at several depths in the central axis of a 12C beam with an energy of 94.98 AMeV using a novel 3D ultrathin silicon diode detector. Data is compared with Monte Carlo calculations providing an excellent agreement (deviations are less than 2% for the most probable lineal energy value) up to the Bragg peak. The results show the feasibility to determine with high precision the lineal energy transfer spectrum of a hadrontherapy beam with these silicon devices.</description><subject>dosimetry</subject><subject>hadrontherapy</subject><subject>Heavy Ion Radiotherapy - instrumentation</subject><subject>Humans</subject><subject>LET</subject><subject>Linear Energy Transfer</subject><subject>microdosimetry</subject><subject>Monte Carlo Method</subject><subject>Physics</subject><subject>Protons</subject><subject>Radiometry - instrumentation</subject><subject>Silicon</subject><subject>silicon detectors</subject><issn>0031-9155</issn><issn>1361-6560</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo7vrxD0R6Ej3UzTRp2j3K-gkrXhS8hbSZslnapiat4r83ZXXxIB7CQOZ534GHkBOgl0DzfEYpg3gOaToTMAOYccrEDpkCExCLVNBdMt0iE3Lg_ZpSgDzh-2SSZCBYnsOUvD6i8oPDBts-slVUKlfYNjLhNaZ0VltvGuydKSNtfJjF0Ieljz5Mv4qGuneqX5k2YteRN7UpQ04bq9Efkb1K1R6Pv-chebm9eV7cx8unu4fF1TIuObA-VhUqYAmqXFUZKxAK4JRXCS-QotDzlCZUacFSkTEoswRFTrOCgUgqnYFS7JBcbHpXqpadM41yn9IqI--vlnL8C1oglPB3COz5hu2cfRvQ97IxvsS6Vi3awUvI5pSLNBcsoHyDBgfeO6y23UDl6F-OcuUoVwqQAHL0H2Kn3xeGokG9Df0ID8DZBjC2k2s7uDbIkV1T_GqRna4CSP8A_z3-BXWzm3U</recordid><startdate>20160607</startdate><enddate>20160607</enddate><creator>Gómez, F</creator><creator>Fleta, C</creator><creator>Esteban, S</creator><creator>Quirion, D</creator><creator>Pellegrini, G</creator><creator>Lozano, M</creator><creator>Prezado, Y</creator><creator>Dos Santos, M</creator><creator>Guardiola, C</creator><creator>Montarou, G</creator><creator>Prieto-Pena, J</creator><creator>Pardo-Montero, Juan</creator><general>IOP Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope></search><sort><creationdate>20160607</creationdate><title>Measurement of carbon ion microdosimetric distributions with ultrathin 3D silicon diodes</title><author>Gómez, F ; Fleta, C ; Esteban, S ; Quirion, D ; Pellegrini, G ; Lozano, M ; Prezado, Y ; Dos Santos, M ; Guardiola, C ; Montarou, G ; Prieto-Pena, J ; Pardo-Montero, Juan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-afea132ea8af73be1b1404f24be0e6d95020ad6356731c72e6807b3162fd71aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>dosimetry</topic><topic>hadrontherapy</topic><topic>Heavy Ion Radiotherapy - instrumentation</topic><topic>Humans</topic><topic>LET</topic><topic>Linear Energy Transfer</topic><topic>microdosimetry</topic><topic>Monte Carlo Method</topic><topic>Physics</topic><topic>Protons</topic><topic>Radiometry - instrumentation</topic><topic>Silicon</topic><topic>silicon detectors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gómez, F</creatorcontrib><creatorcontrib>Fleta, C</creatorcontrib><creatorcontrib>Esteban, S</creatorcontrib><creatorcontrib>Quirion, D</creatorcontrib><creatorcontrib>Pellegrini, G</creatorcontrib><creatorcontrib>Lozano, M</creatorcontrib><creatorcontrib>Prezado, Y</creatorcontrib><creatorcontrib>Dos Santos, M</creatorcontrib><creatorcontrib>Guardiola, C</creatorcontrib><creatorcontrib>Montarou, G</creatorcontrib><creatorcontrib>Prieto-Pena, J</creatorcontrib><creatorcontrib>Pardo-Montero, Juan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Physics in medicine & biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gómez, F</au><au>Fleta, C</au><au>Esteban, S</au><au>Quirion, D</au><au>Pellegrini, G</au><au>Lozano, M</au><au>Prezado, Y</au><au>Dos Santos, M</au><au>Guardiola, C</au><au>Montarou, G</au><au>Prieto-Pena, J</au><au>Pardo-Montero, Juan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Measurement of carbon ion microdosimetric distributions with ultrathin 3D silicon diodes</atitle><jtitle>Physics in medicine & biology</jtitle><stitle>PMB</stitle><addtitle>Phys. 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Data is compared with Monte Carlo calculations providing an excellent agreement (deviations are less than 2% for the most probable lineal energy value) up to the Bragg peak. The results show the feasibility to determine with high precision the lineal energy transfer spectrum of a hadrontherapy beam with these silicon devices.</abstract><cop>England</cop><pub>IOP Publishing</pub><pmid>27163881</pmid><doi>10.1088/0031-9155/61/11/4036</doi><tpages>12</tpages></addata></record> |
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| subjects | dosimetry hadrontherapy Heavy Ion Radiotherapy - instrumentation Humans LET Linear Energy Transfer microdosimetry Monte Carlo Method Physics Protons Radiometry - instrumentation Silicon silicon detectors |
| title | Measurement of carbon ion microdosimetric distributions with ultrathin 3D silicon diodes |
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