Diffuse Reflectance Parameters of Treated Leishmaniasis Cutaneous Ulcers and Association with Histopathologies in an Animal Model: A Proof of Concept
Cutaneous leishmaniasis (CL) is a parasitic disease that produces chronic skin ulcers. Although it has a worldwide presence, it is a neglected disease that still requires novel tools for its management. In order to study the use of optical tools in CL, this article presents a preliminary study of th...
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| Veröffentlicht in: | SLAS technology 2021-12, Vol.26 (6), p.667-680 |
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| creator | Restrepo, Lina Murillo, Javier Botina, Deivid Zarzycki, Artur Garzón, Johnson Franco, Ricardo Montano, Jaime Calderon, Samuel Torres-Madronero, Maria C. Marzani, Franck Robledo, Sara M. Galeano, July |
| description | Cutaneous leishmaniasis (CL) is a parasitic disease that produces chronic skin ulcers. Although it has a worldwide presence, it is a neglected disease that still requires novel tools for its management. In order to study the use of optical tools in CL, this article presents a preliminary study of the correlation between CL histopathological and optical parameters. Optical parameters correspond to absorption and scattering coefficients obtained from diffuse reflectance spectra of treated CL in golden hamsters. Independently, histopathological data were collected from the same hamsters. As a result, after Spearman correlation and the Kruskal–Wallis test, inverse correlation was found between absorption/scattering optical parameters and inflammatory histopathological values, such as the scattering parameter related to the diameter of fibroblasts with the histopathological parameters of fibrosis, polymorphonuclear neutrophils, lymphocytes, plasmocytes, hyperplasia, and Leishmania, and the absorption parameter oxygen saturation showed a relation with the granulation tissue histopathological parameter. These correlations agree with the expected behavior of tissue composition during the healing process in CL. The results correspond to a proof of concept that shows that optical diffuse reflectance-based tools and methods could be considered as an alternative to assist in CL diagnosis and treatment follow-up. |
| doi_str_mv | 10.1177/24726303211030292 |
| format | Article |
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Although it has a worldwide presence, it is a neglected disease that still requires novel tools for its management. In order to study the use of optical tools in CL, this article presents a preliminary study of the correlation between CL histopathological and optical parameters. Optical parameters correspond to absorption and scattering coefficients obtained from diffuse reflectance spectra of treated CL in golden hamsters. Independently, histopathological data were collected from the same hamsters. As a result, after Spearman correlation and the Kruskal–Wallis test, inverse correlation was found between absorption/scattering optical parameters and inflammatory histopathological values, such as the scattering parameter related to the diameter of fibroblasts with the histopathological parameters of fibrosis, polymorphonuclear neutrophils, lymphocytes, plasmocytes, hyperplasia, and Leishmania, and the absorption parameter oxygen saturation showed a relation with the granulation tissue histopathological parameter. These correlations agree with the expected behavior of tissue composition during the healing process in CL. The results correspond to a proof of concept that shows that optical diffuse reflectance-based tools and methods could be considered as an alternative to assist in CL diagnosis and treatment follow-up.</description><identifier>ISSN: 2472-6303</identifier><identifier>EISSN: 2472-6311</identifier><identifier>DOI: 10.1177/24726303211030292</identifier><identifier>PMID: 34292085</identifier><language>eng</language><publisher>Los Angeles, CA: Elsevier Inc</publisher><subject>animal model ; Animals ; Artificial Intelligence ; Computer Science ; Computer Vision and Pattern Recognition ; Cricetinae ; cutaneous leishmaniasis ; cutaneous ulcers ; diffuse reflectance ; histopathologies ; Image Processing ; Leishmaniasis, Cutaneous - diagnosis ; Leishmaniasis, Cutaneous - drug therapy ; Lymphocytes ; Oxygen Saturation ; Signal and Image Processing ; Skin Ulcer ; Ulcer</subject><ispartof>SLAS technology, 2021-12, Vol.26 (6), p.667-680</ispartof><rights>2021 Society for Laboratory Automation and Screening</rights><rights>Society for Laboratory Automation and Screening 2021</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c421t-6af110226af2f0b508a30762d130646b6da641a28b2a46e03226c59e5defdd983</cites><orcidid>0000-0002-4349-1431 ; 0000-0003-0963-1565</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34292085$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03609710$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Restrepo, Lina</creatorcontrib><creatorcontrib>Murillo, Javier</creatorcontrib><creatorcontrib>Botina, Deivid</creatorcontrib><creatorcontrib>Zarzycki, Artur</creatorcontrib><creatorcontrib>Garzón, Johnson</creatorcontrib><creatorcontrib>Franco, Ricardo</creatorcontrib><creatorcontrib>Montano, Jaime</creatorcontrib><creatorcontrib>Calderon, Samuel</creatorcontrib><creatorcontrib>Torres-Madronero, Maria C.</creatorcontrib><creatorcontrib>Marzani, Franck</creatorcontrib><creatorcontrib>Robledo, Sara M.</creatorcontrib><creatorcontrib>Galeano, July</creatorcontrib><title>Diffuse Reflectance Parameters of Treated Leishmaniasis Cutaneous Ulcers and Association with Histopathologies in an Animal Model: A Proof of Concept</title><title>SLAS technology</title><addtitle>SLAS Technol</addtitle><description>Cutaneous leishmaniasis (CL) is a parasitic disease that produces chronic skin ulcers. Although it has a worldwide presence, it is a neglected disease that still requires novel tools for its management. In order to study the use of optical tools in CL, this article presents a preliminary study of the correlation between CL histopathological and optical parameters. Optical parameters correspond to absorption and scattering coefficients obtained from diffuse reflectance spectra of treated CL in golden hamsters. Independently, histopathological data were collected from the same hamsters. As a result, after Spearman correlation and the Kruskal–Wallis test, inverse correlation was found between absorption/scattering optical parameters and inflammatory histopathological values, such as the scattering parameter related to the diameter of fibroblasts with the histopathological parameters of fibrosis, polymorphonuclear neutrophils, lymphocytes, plasmocytes, hyperplasia, and Leishmania, and the absorption parameter oxygen saturation showed a relation with the granulation tissue histopathological parameter. These correlations agree with the expected behavior of tissue composition during the healing process in CL. The results correspond to a proof of concept that shows that optical diffuse reflectance-based tools and methods could be considered as an alternative to assist in CL diagnosis and treatment follow-up.</description><subject>animal model</subject><subject>Animals</subject><subject>Artificial Intelligence</subject><subject>Computer Science</subject><subject>Computer Vision and Pattern Recognition</subject><subject>Cricetinae</subject><subject>cutaneous leishmaniasis</subject><subject>cutaneous ulcers</subject><subject>diffuse reflectance</subject><subject>histopathologies</subject><subject>Image Processing</subject><subject>Leishmaniasis, Cutaneous - diagnosis</subject><subject>Leishmaniasis, Cutaneous - drug therapy</subject><subject>Lymphocytes</subject><subject>Oxygen Saturation</subject><subject>Signal and Image Processing</subject><subject>Skin Ulcer</subject><subject>Ulcer</subject><issn>2472-6303</issn><issn>2472-6311</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9q3DAQxk1paEKSB-il6NgeNtEfS95tT2aTZgtbGkpyFrPWOKtgW1uNnNIHyftWi9O9FAKCEcPv-0b6pijeC34hRFVdyrKSRnElheCKy4V8U5zsezOjhHh7uHN1XJwTPXLORWWUUdW74liVmedzfVI8X_m2HQnZT2w7bBIMDbJbiNBjwkgstOwuIiR0bI2etj0MHsgTW46ZxTASu--aPQmDYzVRaDwkHwb226ctW3lKYQdpG7rw4JGYHzLI6sH30LHvwWH3mdXsNoY8KJ9lyPN36aw4aqEjPH-pp8X91-u75Wq2_nHzbVmvZ00pRZoZaPPnpcxVtnyj-RwUr4x0QnFTmo1xYEoBcr6RUBrMWUnT6AVqh61zi7k6LT5Nvlvo7C7mR8U_NoC3q3pt9z2uDF9Ugj-JzH6c2F0Mv0akZHtPDXbdFIOVWpdKC13pjIoJbWIgitgevAW3--XZ_5aXNR9e7MdNj-6g-LeqDFxMAMED2scwxiFH86rjl0mAOcEnj9FS4zHn63zMm7Yu-FfUfwEyN7N7</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Restrepo, Lina</creator><creator>Murillo, Javier</creator><creator>Botina, Deivid</creator><creator>Zarzycki, Artur</creator><creator>Garzón, Johnson</creator><creator>Franco, Ricardo</creator><creator>Montano, Jaime</creator><creator>Calderon, Samuel</creator><creator>Torres-Madronero, Maria C.</creator><creator>Marzani, Franck</creator><creator>Robledo, Sara M.</creator><creator>Galeano, July</creator><general>Elsevier Inc</general><general>SAGE Publications</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-4349-1431</orcidid><orcidid>https://orcid.org/0000-0003-0963-1565</orcidid></search><sort><creationdate>202112</creationdate><title>Diffuse Reflectance Parameters of Treated Leishmaniasis Cutaneous Ulcers and Association with Histopathologies in an Animal Model: A Proof of Concept</title><author>Restrepo, Lina ; Murillo, Javier ; Botina, Deivid ; Zarzycki, Artur ; Garzón, Johnson ; Franco, Ricardo ; Montano, Jaime ; Calderon, Samuel ; Torres-Madronero, Maria C. ; Marzani, Franck ; Robledo, Sara M. ; Galeano, July</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-6af110226af2f0b508a30762d130646b6da641a28b2a46e03226c59e5defdd983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>animal model</topic><topic>Animals</topic><topic>Artificial Intelligence</topic><topic>Computer Science</topic><topic>Computer Vision and Pattern Recognition</topic><topic>Cricetinae</topic><topic>cutaneous leishmaniasis</topic><topic>cutaneous ulcers</topic><topic>diffuse reflectance</topic><topic>histopathologies</topic><topic>Image Processing</topic><topic>Leishmaniasis, Cutaneous - diagnosis</topic><topic>Leishmaniasis, Cutaneous - drug therapy</topic><topic>Lymphocytes</topic><topic>Oxygen Saturation</topic><topic>Signal and Image Processing</topic><topic>Skin Ulcer</topic><topic>Ulcer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Restrepo, Lina</creatorcontrib><creatorcontrib>Murillo, Javier</creatorcontrib><creatorcontrib>Botina, Deivid</creatorcontrib><creatorcontrib>Zarzycki, Artur</creatorcontrib><creatorcontrib>Garzón, Johnson</creatorcontrib><creatorcontrib>Franco, Ricardo</creatorcontrib><creatorcontrib>Montano, Jaime</creatorcontrib><creatorcontrib>Calderon, Samuel</creatorcontrib><creatorcontrib>Torres-Madronero, Maria C.</creatorcontrib><creatorcontrib>Marzani, Franck</creatorcontrib><creatorcontrib>Robledo, Sara M.</creatorcontrib><creatorcontrib>Galeano, July</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>SLAS technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Restrepo, Lina</au><au>Murillo, Javier</au><au>Botina, Deivid</au><au>Zarzycki, Artur</au><au>Garzón, Johnson</au><au>Franco, Ricardo</au><au>Montano, Jaime</au><au>Calderon, Samuel</au><au>Torres-Madronero, Maria C.</au><au>Marzani, Franck</au><au>Robledo, Sara M.</au><au>Galeano, July</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diffuse Reflectance Parameters of Treated Leishmaniasis Cutaneous Ulcers and Association with Histopathologies in an Animal Model: A Proof of Concept</atitle><jtitle>SLAS technology</jtitle><addtitle>SLAS Technol</addtitle><date>2021-12</date><risdate>2021</risdate><volume>26</volume><issue>6</issue><spage>667</spage><epage>680</epage><pages>667-680</pages><issn>2472-6303</issn><eissn>2472-6311</eissn><abstract>Cutaneous leishmaniasis (CL) is a parasitic disease that produces chronic skin ulcers. Although it has a worldwide presence, it is a neglected disease that still requires novel tools for its management. In order to study the use of optical tools in CL, this article presents a preliminary study of the correlation between CL histopathological and optical parameters. Optical parameters correspond to absorption and scattering coefficients obtained from diffuse reflectance spectra of treated CL in golden hamsters. Independently, histopathological data were collected from the same hamsters. As a result, after Spearman correlation and the Kruskal–Wallis test, inverse correlation was found between absorption/scattering optical parameters and inflammatory histopathological values, such as the scattering parameter related to the diameter of fibroblasts with the histopathological parameters of fibrosis, polymorphonuclear neutrophils, lymphocytes, plasmocytes, hyperplasia, and Leishmania, and the absorption parameter oxygen saturation showed a relation with the granulation tissue histopathological parameter. These correlations agree with the expected behavior of tissue composition during the healing process in CL. The results correspond to a proof of concept that shows that optical diffuse reflectance-based tools and methods could be considered as an alternative to assist in CL diagnosis and treatment follow-up.</abstract><cop>Los Angeles, CA</cop><pub>Elsevier Inc</pub><pmid>34292085</pmid><doi>10.1177/24726303211030292</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-4349-1431</orcidid><orcidid>https://orcid.org/0000-0003-0963-1565</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | animal model Animals Artificial Intelligence Computer Science Computer Vision and Pattern Recognition Cricetinae cutaneous leishmaniasis cutaneous ulcers diffuse reflectance histopathologies Image Processing Leishmaniasis, Cutaneous - diagnosis Leishmaniasis, Cutaneous - drug therapy Lymphocytes Oxygen Saturation Signal and Image Processing Skin Ulcer Ulcer |
| title | Diffuse Reflectance Parameters of Treated Leishmaniasis Cutaneous Ulcers and Association with Histopathologies in an Animal Model: A Proof of Concept |
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