Failure to respond to ribavirin despite elevated intra‐erythrocyte zinc level in transplant‐patients with chronic hepatitis E virus infection
Ribavirin was showed to be very effective for treating chronic hep‐atitis E virus (HEV) infection in immunosuppressed patients, especially in solid organ transplant patients in whom it allows to achieve a sustained virological response in nearly 90% of them. However, in few patients, despite a retre...
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| Veröffentlicht in: | Transplant infectious disease 2019-04, Vol.21 (2), p.e13050-n/a |
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| creator | Marion, Olivier Abravanel, Florence Izopet, Jacques Kamar, Nassim |
| description | Ribavirin was showed to be very effective for treating chronic hep‐atitis E virus (HEV) infection in immunosuppressed patients, especially in solid organ transplant patients in whom it allows to achieve a sustained virological response in nearly 90% of them. However, in few patients, despite a retreatment by ribavirin for a longer period or adding other antiviral drugs such as sofosbuvir, HEV RNA remains detectable. Recently, zinc salt, which is known to reduce infections induced by viruses, was tested in vitro against HEV. It has been shown that it inhibits the activity of viral RNA‐dependent RNA polymerase(RdRp), leading to inhibition of HEV replication.3,4 In addition, it has a synergistic effect with ribavirin on HEV replication. Herein, we report two cases of chronic HEV infection in which we failed to obtain HEV clearance despite normal and increased intra‐erythrocyte zinc levels measured by an atomic absorption spectrophotometer. |
| doi_str_mv | 10.1111/tid.13050 |
| format | Article |
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However, in few patients, despite a retreatment by ribavirin for a longer period or adding other antiviral drugs such as sofosbuvir, HEV RNA remains detectable. Recently, zinc salt, which is known to reduce infections induced by viruses, was tested in vitro against HEV. It has been shown that it inhibits the activity of viral RNA‐dependent RNA polymerase(RdRp), leading to inhibition of HEV replication.3,4 In addition, it has a synergistic effect with ribavirin on HEV replication. Herein, we report two cases of chronic HEV infection in which we failed to obtain HEV clearance despite normal and increased intra‐erythrocyte zinc levels measured by an atomic absorption spectrophotometer.</description><identifier>ISSN: 1398-2273</identifier><identifier>EISSN: 1399-3062</identifier><identifier>DOI: 10.1111/tid.13050</identifier><identifier>PMID: 30663838</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Antiviral Agents / therapeutic use ; Chronic Disease ; Chronic infection ; Erythrocytes ; Erythrocytes / chemistry ; Female ; Hepatitis ; Hepatitis E / drug therapy ; hepatitis E virus ; Hepatitis E virus / drug effects ; Humans ; Immunocompromised Host / drug effects ; Immunology ; Life Sciences ; Microbiology and Parasitology ; Middle Aged ; Ribavirin ; Ribavirin / therapeutic use ; RNA, Viral / blood ; sustained virological response ; Transplant Recipients ; transplantation ; Treatment Failure ; Virology ; Viruses ; Zinc ; Zinc / analysis</subject><ispartof>Transplant infectious disease, 2019-04, Vol.21 (2), p.e13050-n/a</ispartof><rights>2019 John Wiley & Sons A/S. 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However, in few patients, despite a retreatment by ribavirin for a longer period or adding other antiviral drugs such as sofosbuvir, HEV RNA remains detectable. Recently, zinc salt, which is known to reduce infections induced by viruses, was tested in vitro against HEV. It has been shown that it inhibits the activity of viral RNA‐dependent RNA polymerase(RdRp), leading to inhibition of HEV replication.3,4 In addition, it has a synergistic effect with ribavirin on HEV replication. Herein, we report two cases of chronic HEV infection in which we failed to obtain HEV clearance despite normal and increased intra‐erythrocyte zinc levels measured by an atomic absorption spectrophotometer.</description><subject>Antiviral Agents / therapeutic use</subject><subject>Chronic Disease</subject><subject>Chronic infection</subject><subject>Erythrocytes</subject><subject>Erythrocytes / chemistry</subject><subject>Female</subject><subject>Hepatitis</subject><subject>Hepatitis E / drug therapy</subject><subject>hepatitis E virus</subject><subject>Hepatitis E virus / drug effects</subject><subject>Humans</subject><subject>Immunocompromised Host / drug effects</subject><subject>Immunology</subject><subject>Life Sciences</subject><subject>Microbiology and Parasitology</subject><subject>Middle Aged</subject><subject>Ribavirin</subject><subject>Ribavirin / therapeutic use</subject><subject>RNA, Viral / blood</subject><subject>sustained virological response</subject><subject>Transplant Recipients</subject><subject>transplantation</subject><subject>Treatment Failure</subject><subject>Virology</subject><subject>Viruses</subject><subject>Zinc</subject><subject>Zinc / analysis</subject><issn>1398-2273</issn><issn>1399-3062</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kbtOxDAQRS0E4l3wA8gSFUUWP7JJXCLe0ko0UFuOPdEaBSfYzqKl4hPgF_kSvA-gwo1Hc8_csXUROqJkRNM5i9aMKCdjsoF2KRci46Rgm8u6yhgr-Q7aC-GJEFqKXGyjnaQXvOLVLvq8VrYdPODYYQ-h75xZlrZWM-utwyY1bQQMLcxUBIOti159vX-An8ep7_Q8iW_WaZwAaJOMk-5C3yoXE9araMHFgF9tnGKdJpzVeAqLfrQBX-G0ZwhprgEdbecO0Faj2gCH63sfPV5fPVzcZpP7m7uL80mm-TgnWfqbBg61MYzljDJTqYKXFCqidUN1LhQvG8WrRhkKVFSCmoKbusgZE7w2lO-j05XvVLWy9_ZZ-bnslJW35xO56BFeEEHH-WzBnqzY3ncvA4Qon7rBu_Q8yRjhlJG8JH-O2ncheGh-bSmRi6BkCkoug0rs8dpxqJ_B_JI_ySTgbAW82hbm_zvJh7vLleU3lR2hGw</recordid><startdate>201904</startdate><enddate>201904</enddate><creator>Marion, Olivier</creator><creator>Abravanel, Florence</creator><creator>Izopet, Jacques</creator><creator>Kamar, Nassim</creator><general>Wiley Subscription Services, Inc</general><general>Wiley</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0003-1930-8964</orcidid><orcidid>https://orcid.org/0000-0002-8462-3234</orcidid><orcidid>https://orcid.org/0000-0002-1753-1065</orcidid><orcidid>https://orcid.org/0000-0001-9702-1833</orcidid></search><sort><creationdate>201904</creationdate><title>Failure to respond to ribavirin despite elevated intra‐erythrocyte zinc level in transplant‐patients with chronic hepatitis E virus infection</title><author>Marion, Olivier ; Abravanel, Florence ; Izopet, Jacques ; Kamar, Nassim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3540-139ce3ebdd224212d8a6371e80ccf1c49a37fa38fad1e19891d63db642293bd13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Antiviral Agents / therapeutic use</topic><topic>Chronic Disease</topic><topic>Chronic infection</topic><topic>Erythrocytes</topic><topic>Erythrocytes / chemistry</topic><topic>Female</topic><topic>Hepatitis</topic><topic>Hepatitis E / drug therapy</topic><topic>hepatitis E virus</topic><topic>Hepatitis E virus / drug effects</topic><topic>Humans</topic><topic>Immunocompromised Host / drug effects</topic><topic>Immunology</topic><topic>Life Sciences</topic><topic>Microbiology and Parasitology</topic><topic>Middle Aged</topic><topic>Ribavirin</topic><topic>Ribavirin / therapeutic use</topic><topic>RNA, Viral / blood</topic><topic>sustained virological response</topic><topic>Transplant Recipients</topic><topic>transplantation</topic><topic>Treatment Failure</topic><topic>Virology</topic><topic>Viruses</topic><topic>Zinc</topic><topic>Zinc / analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marion, Olivier</creatorcontrib><creatorcontrib>Abravanel, Florence</creatorcontrib><creatorcontrib>Izopet, Jacques</creatorcontrib><creatorcontrib>Kamar, Nassim</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Transplant infectious disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marion, Olivier</au><au>Abravanel, Florence</au><au>Izopet, Jacques</au><au>Kamar, Nassim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Failure to respond to ribavirin despite elevated intra‐erythrocyte zinc level in transplant‐patients with chronic hepatitis E virus infection</atitle><jtitle>Transplant infectious disease</jtitle><addtitle>Transpl Infect Dis</addtitle><date>2019-04</date><risdate>2019</risdate><volume>21</volume><issue>2</issue><spage>e13050</spage><epage>n/a</epage><pages>e13050-n/a</pages><issn>1398-2273</issn><eissn>1399-3062</eissn><abstract>Ribavirin was showed to be very effective for treating chronic hep‐atitis E virus (HEV) infection in immunosuppressed patients, especially in solid organ transplant patients in whom it allows to achieve a sustained virological response in nearly 90% of them. 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| ispartof | Transplant infectious disease, 2019-04, Vol.21 (2), p.e13050-n/a |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Antiviral Agents / therapeutic use Chronic Disease Chronic infection Erythrocytes Erythrocytes / chemistry Female Hepatitis Hepatitis E / drug therapy hepatitis E virus Hepatitis E virus / drug effects Humans Immunocompromised Host / drug effects Immunology Life Sciences Microbiology and Parasitology Middle Aged Ribavirin Ribavirin / therapeutic use RNA, Viral / blood sustained virological response Transplant Recipients transplantation Treatment Failure Virology Viruses Zinc Zinc / analysis |
| title | Failure to respond to ribavirin despite elevated intra‐erythrocyte zinc level in transplant‐patients with chronic hepatitis E virus infection |
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