Revisiting the Concept of Stress in the Prognosis of Solid Tumors: A Role for Stress Granules Proteins?

Revisiting the Concept of Stress in the Prognosis of Solid Tumors: A Role for Stress Granules Proteins?

Cancer treatments are constantly evolving with new approaches to improve patient outcomes. Despite progresses, too many patients remain refractory to treatment due to either the development of resistance to therapeutic drugs and/or metastasis occurrence. Growing evidence suggests that these two barr...

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Veröffentlicht in:Cancers 2020-09, Vol.12 (9)
Hauptverfasser: Aulas, Anaïs, Finetti, Pascal, Lyons, Shawn, Bertucci, François, Birnbaum, Daniel, Acquaviva, Claire, Mamessier, Emilie
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Cancer
Immunology
Immunotherapy
Life Sciences
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container_issue 9
container_start_page
container_title Cancers
container_volume 12
creator Aulas, Anaïs
Finetti, Pascal
Lyons, Shawn
Bertucci, François
Birnbaum, Daniel
Acquaviva, Claire
Mamessier, Emilie
description Cancer treatments are constantly evolving with new approaches to improve patient outcomes. Despite progresses, too many patients remain refractory to treatment due to either the development of resistance to therapeutic drugs and/or metastasis occurrence. Growing evidence suggests that these two barriers are due to transient survival mechanisms that are similar to those observed during stress response. We review the literature and current available open databases to study the potential role of stress response and, most particularly, the involvement of Stress Granules (proteins) in cancer. We propose that Stress Granule proteins may have prognostic value for patients.
doi_str_mv 10.3390/cancers12092470
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source PubMed Central (Open Access); MDPI - Multidisciplinary Digital Publishing Institute; EZB Electronic Journals Library; PubMed Central Open Access
subjects Cancer
Immunology
Immunotherapy
Life Sciences
title Revisiting the Concept of Stress in the Prognosis of Solid Tumors: A Role for Stress Granules Proteins?
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