Shedding light on interictal epileptic spikes: An in vivo study using fast optical signal and electrocorticography
Summary Objective Interictal epileptic spikes (IESs), apart from being a key marker of epileptic neuronal networks, constitute a nice model of the widespread endogenous phenomenon of neuronal hypersynchronization. Many questions concerning the mechanisms that drive neurons to hypersynchronize remain...
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| Veröffentlicht in: | Epilepsia (Copenhagen) 2017-04, Vol.58 (4), p.608-616 |
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| creator | Manoochehri, Mana Mahmoudzadeh, Mahdi Osharina, Victoria Wallois, Fabrice |
| description | Summary
Objective
Interictal epileptic spikes (IESs), apart from being a key marker of epileptic neuronal networks, constitute a nice model of the widespread endogenous phenomenon of neuronal hypersynchronization. Many questions concerning the mechanisms that drive neurons to hypersynchronize remain unresolved, but synaptic as well as nonsynaptic events are likely to be involved. In this study, changes in optical properties of neural tissues were observed in rats with penicillin‐induced IES using fast optical signal (FOS) concomitantly with electrocorticography (ECoG).
Methods
In this study, near‐infrared optical imaging was used with ECoG to investigate variations in the optical properties of cortical tissue directly associated with neuronal activity in 15 rats. FOS changes correspond to variations of scattered light from neuronal tissue when neurons are activated. To independently evaluate our method, a control experiment on somatosensory was designed and applied to seven different rats. Time‐frequency analysis was also used to track variations of (de)synchronization concomitantly with changes in optical signals during IES.
Results
FOS responses revealed that changes in optical signals occurred 320 msec before to 370 msec after the IES peak. These changes started before any changes in ECoG signal. In addition, time‐frequency domain electrocorticography revealed an alternating decrease‐increase‐decrease in the ECoG spectral power (pointing to desynchronization‐synchronization‐desynchronization), which occurred concomitantly with an increase‐decrease‐increase in relative optical signal during the IES. These results suggest a relationship between (de)synchronization and optical changes.
Significance
These changes in the neuronal environment around IESs raise new questions about the mechanisms that induce changes in optical properties of neural tissues before the IES, which may provide suitable conditions for neuronal synchronization during IESs. FOS‐ECoG constitutes a multimodal approach and opens new avenues to study the mechanisms of neuronal synchronization in the pathologic brain, which has clinical implications, at least in epilepsy. |
| doi_str_mv | 10.1111/epi.13689 |
| format | Article |
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Objective
Interictal epileptic spikes (IESs), apart from being a key marker of epileptic neuronal networks, constitute a nice model of the widespread endogenous phenomenon of neuronal hypersynchronization. Many questions concerning the mechanisms that drive neurons to hypersynchronize remain unresolved, but synaptic as well as nonsynaptic events are likely to be involved. In this study, changes in optical properties of neural tissues were observed in rats with penicillin‐induced IES using fast optical signal (FOS) concomitantly with electrocorticography (ECoG).
Methods
In this study, near‐infrared optical imaging was used with ECoG to investigate variations in the optical properties of cortical tissue directly associated with neuronal activity in 15 rats. FOS changes correspond to variations of scattered light from neuronal tissue when neurons are activated. To independently evaluate our method, a control experiment on somatosensory was designed and applied to seven different rats. Time‐frequency analysis was also used to track variations of (de)synchronization concomitantly with changes in optical signals during IES.
Results
FOS responses revealed that changes in optical signals occurred 320 msec before to 370 msec after the IES peak. These changes started before any changes in ECoG signal. In addition, time‐frequency domain electrocorticography revealed an alternating decrease‐increase‐decrease in the ECoG spectral power (pointing to desynchronization‐synchronization‐desynchronization), which occurred concomitantly with an increase‐decrease‐increase in relative optical signal during the IES. These results suggest a relationship between (de)synchronization and optical changes.
Significance
These changes in the neuronal environment around IESs raise new questions about the mechanisms that induce changes in optical properties of neural tissues before the IES, which may provide suitable conditions for neuronal synchronization during IESs. FOS‐ECoG constitutes a multimodal approach and opens new avenues to study the mechanisms of neuronal synchronization in the pathologic brain, which has clinical implications, at least in epilepsy.</description><identifier>ISSN: 0013-9580</identifier><identifier>EISSN: 1528-1167</identifier><identifier>EISSN: 1528-1157</identifier><identifier>DOI: 10.1111/epi.13689</identifier><identifier>PMID: 28117493</identifier><language>eng</language><publisher>United States: Wiley</publisher><subject>(De)synchronization ; Action Potentials - drug effects ; Action Potentials - physiology ; Animals ; Cell shrinking‐swelling ; ECoG ; Electrocorticography ; Electrodes, Implanted ; Electroencephalography ; Epilepsy - chemically induced ; Epilepsy - pathology ; Fast optical signal ; Female ; Interictal epileptic spike ; Life Sciences ; Male ; Neurons - drug effects ; Neurons - physiology ; Penicillins - toxicity ; Rats ; Rats, Sprague-Dawley ; Spectroscopy, Near-Infrared ; Spectrum Analysis ; Time Factors</subject><ispartof>Epilepsia (Copenhagen), 2017-04, Vol.58 (4), p.608-616</ispartof><rights>Wiley Periodicals, Inc. © 2017 International League Against Epilepsy</rights><rights>Wiley Periodicals, Inc. © 2017 International League Against Epilepsy.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4609-aa92c6a08275a67c1eb8e055caeeea5416538a2790bf6a2ec19a3e5b020f327c3</citedby><cites>FETCH-LOGICAL-c4609-aa92c6a08275a67c1eb8e055caeeea5416538a2790bf6a2ec19a3e5b020f327c3</cites><orcidid>0000-0001-7585-5714 ; 0000-0003-3145-2133 ; 0000-0003-2928-5428</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fepi.13689$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fepi.13689$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1416,1432,27922,27923,45572,45573,46407,46831</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28117493$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://u-picardie.hal.science/hal-03603382$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Manoochehri, Mana</creatorcontrib><creatorcontrib>Mahmoudzadeh, Mahdi</creatorcontrib><creatorcontrib>Osharina, Victoria</creatorcontrib><creatorcontrib>Wallois, Fabrice</creatorcontrib><title>Shedding light on interictal epileptic spikes: An in vivo study using fast optical signal and electrocorticography</title><title>Epilepsia (Copenhagen)</title><addtitle>Epilepsia</addtitle><description>Summary
Objective
Interictal epileptic spikes (IESs), apart from being a key marker of epileptic neuronal networks, constitute a nice model of the widespread endogenous phenomenon of neuronal hypersynchronization. Many questions concerning the mechanisms that drive neurons to hypersynchronize remain unresolved, but synaptic as well as nonsynaptic events are likely to be involved. In this study, changes in optical properties of neural tissues were observed in rats with penicillin‐induced IES using fast optical signal (FOS) concomitantly with electrocorticography (ECoG).
Methods
In this study, near‐infrared optical imaging was used with ECoG to investigate variations in the optical properties of cortical tissue directly associated with neuronal activity in 15 rats. FOS changes correspond to variations of scattered light from neuronal tissue when neurons are activated. To independently evaluate our method, a control experiment on somatosensory was designed and applied to seven different rats. Time‐frequency analysis was also used to track variations of (de)synchronization concomitantly with changes in optical signals during IES.
Results
FOS responses revealed that changes in optical signals occurred 320 msec before to 370 msec after the IES peak. These changes started before any changes in ECoG signal. In addition, time‐frequency domain electrocorticography revealed an alternating decrease‐increase‐decrease in the ECoG spectral power (pointing to desynchronization‐synchronization‐desynchronization), which occurred concomitantly with an increase‐decrease‐increase in relative optical signal during the IES. These results suggest a relationship between (de)synchronization and optical changes.
Significance
These changes in the neuronal environment around IESs raise new questions about the mechanisms that induce changes in optical properties of neural tissues before the IES, which may provide suitable conditions for neuronal synchronization during IESs. FOS‐ECoG constitutes a multimodal approach and opens new avenues to study the mechanisms of neuronal synchronization in the pathologic brain, which has clinical implications, at least in epilepsy.</description><subject>(De)synchronization</subject><subject>Action Potentials - drug effects</subject><subject>Action Potentials - physiology</subject><subject>Animals</subject><subject>Cell shrinking‐swelling</subject><subject>ECoG</subject><subject>Electrocorticography</subject><subject>Electrodes, Implanted</subject><subject>Electroencephalography</subject><subject>Epilepsy - chemically induced</subject><subject>Epilepsy - pathology</subject><subject>Fast optical signal</subject><subject>Female</subject><subject>Interictal epileptic spike</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Neurons - drug effects</subject><subject>Neurons - physiology</subject><subject>Penicillins - toxicity</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Spectroscopy, Near-Infrared</subject><subject>Spectrum Analysis</subject><subject>Time Factors</subject><issn>0013-9580</issn><issn>1528-1167</issn><issn>1528-1157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1P3DAQhq2qVdnSHvgDyMf2EPDHxna4rRAtSCsVCThbs85k15CNg51stf8ep0vpCV9G8jzvc3iHkBPOznh-59j7My6VqT6QGS-FKThX-iOZMcZlUZWGHZEvKT0yxrTS8jM5EoZzPa_kjMS7Dda179a09evNQENHfTdg9G6AlmZxi_3gHU29f8J0QRfTnu78LtA0jPWejmkKN5BydiJzKvl1lwd0NcUW3RCDCzGvwjpCv9l_JZ8aaBN-e53H5OHn1f3ldbH8_evmcrEs3FyxqgCohFPAjNAlKO04rgyysnSAiFDOuSqlAaErtmoUCHS8AonlignWSKGdPCY_Dt4NtLaPfgtxbwN4e71Y2umPScWkNGLHM_v9wPYxPI-YBrv1yWHbQodhTJYbxRXXgqn_WhdDShGbNzdndjqHza3Zv-fI7OmrdlxtsX4j__WfgfMD8CcXvX_fZK9ubw7KF-tIlRE</recordid><startdate>201704</startdate><enddate>201704</enddate><creator>Manoochehri, Mana</creator><creator>Mahmoudzadeh, Mahdi</creator><creator>Osharina, Victoria</creator><creator>Wallois, Fabrice</creator><general>Wiley</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-7585-5714</orcidid><orcidid>https://orcid.org/0000-0003-3145-2133</orcidid><orcidid>https://orcid.org/0000-0003-2928-5428</orcidid></search><sort><creationdate>201704</creationdate><title>Shedding light on interictal epileptic spikes: An in vivo study using fast optical signal and electrocorticography</title><author>Manoochehri, Mana ; Mahmoudzadeh, Mahdi ; Osharina, Victoria ; Wallois, Fabrice</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4609-aa92c6a08275a67c1eb8e055caeeea5416538a2790bf6a2ec19a3e5b020f327c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>(De)synchronization</topic><topic>Action Potentials - drug effects</topic><topic>Action Potentials - physiology</topic><topic>Animals</topic><topic>Cell shrinking‐swelling</topic><topic>ECoG</topic><topic>Electrocorticography</topic><topic>Electrodes, Implanted</topic><topic>Electroencephalography</topic><topic>Epilepsy - chemically induced</topic><topic>Epilepsy - pathology</topic><topic>Fast optical signal</topic><topic>Female</topic><topic>Interictal epileptic spike</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Neurons - drug effects</topic><topic>Neurons - physiology</topic><topic>Penicillins - toxicity</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Spectroscopy, Near-Infrared</topic><topic>Spectrum Analysis</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Manoochehri, Mana</creatorcontrib><creatorcontrib>Mahmoudzadeh, Mahdi</creatorcontrib><creatorcontrib>Osharina, Victoria</creatorcontrib><creatorcontrib>Wallois, Fabrice</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Epilepsia (Copenhagen)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Manoochehri, Mana</au><au>Mahmoudzadeh, Mahdi</au><au>Osharina, Victoria</au><au>Wallois, Fabrice</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Shedding light on interictal epileptic spikes: An in vivo study using fast optical signal and electrocorticography</atitle><jtitle>Epilepsia (Copenhagen)</jtitle><addtitle>Epilepsia</addtitle><date>2017-04</date><risdate>2017</risdate><volume>58</volume><issue>4</issue><spage>608</spage><epage>616</epage><pages>608-616</pages><issn>0013-9580</issn><eissn>1528-1167</eissn><eissn>1528-1157</eissn><abstract>Summary
Objective
Interictal epileptic spikes (IESs), apart from being a key marker of epileptic neuronal networks, constitute a nice model of the widespread endogenous phenomenon of neuronal hypersynchronization. Many questions concerning the mechanisms that drive neurons to hypersynchronize remain unresolved, but synaptic as well as nonsynaptic events are likely to be involved. In this study, changes in optical properties of neural tissues were observed in rats with penicillin‐induced IES using fast optical signal (FOS) concomitantly with electrocorticography (ECoG).
Methods
In this study, near‐infrared optical imaging was used with ECoG to investigate variations in the optical properties of cortical tissue directly associated with neuronal activity in 15 rats. FOS changes correspond to variations of scattered light from neuronal tissue when neurons are activated. To independently evaluate our method, a control experiment on somatosensory was designed and applied to seven different rats. Time‐frequency analysis was also used to track variations of (de)synchronization concomitantly with changes in optical signals during IES.
Results
FOS responses revealed that changes in optical signals occurred 320 msec before to 370 msec after the IES peak. These changes started before any changes in ECoG signal. In addition, time‐frequency domain electrocorticography revealed an alternating decrease‐increase‐decrease in the ECoG spectral power (pointing to desynchronization‐synchronization‐desynchronization), which occurred concomitantly with an increase‐decrease‐increase in relative optical signal during the IES. These results suggest a relationship between (de)synchronization and optical changes.
Significance
These changes in the neuronal environment around IESs raise new questions about the mechanisms that induce changes in optical properties of neural tissues before the IES, which may provide suitable conditions for neuronal synchronization during IESs. FOS‐ECoG constitutes a multimodal approach and opens new avenues to study the mechanisms of neuronal synchronization in the pathologic brain, which has clinical implications, at least in epilepsy.</abstract><cop>United States</cop><pub>Wiley</pub><pmid>28117493</pmid><doi>10.1111/epi.13689</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-7585-5714</orcidid><orcidid>https://orcid.org/0000-0003-3145-2133</orcidid><orcidid>https://orcid.org/0000-0003-2928-5428</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Free Content; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | (De)synchronization Action Potentials - drug effects Action Potentials - physiology Animals Cell shrinking‐swelling ECoG Electrocorticography Electrodes, Implanted Electroencephalography Epilepsy - chemically induced Epilepsy - pathology Fast optical signal Female Interictal epileptic spike Life Sciences Male Neurons - drug effects Neurons - physiology Penicillins - toxicity Rats Rats, Sprague-Dawley Spectroscopy, Near-Infrared Spectrum Analysis Time Factors |
| title | Shedding light on interictal epileptic spikes: An in vivo study using fast optical signal and electrocorticography |
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